本文選題：2型糖尿病 + 胎盤生長因子(PLGF)　； 參考：《蘇州大學(xué)》2015年碩士論文

【摘要】：目的:探討2型糖尿病(T2DM)患者血清胎盤生長因子(PLGF)與頸動脈粥樣硬化(AS)的相關(guān)性,通過分析PLGF與糖脂代謝及炎癥因子的相關(guān)性,為闡明其在2型糖尿病患者頸動脈粥樣硬化過程中所起的作用提供一定的理論依據(jù),探討其作為糖尿病頸動脈粥樣硬化及其它心血管并發(fā)癥早期診斷、干預(yù)及治療靶點(diǎn)的可能性。方法:根據(jù)彩色多普勒超聲儀檢查雙側(cè)頸動脈的結(jié)果,將53例2型糖尿病患者分為T2DM無頸動脈粥樣斑塊組(T2DM+NAS組,27例)、T2DM合并頸動脈粥樣斑塊組(T2DM+AS組,26例);同期門診健康體檢者26例為正常對照組(NC組)。測量血壓、身高、體重、空腹血糖(FPG)、總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、胰島素(FINS)、糖化血紅蛋白(Hb Alc)、超敏C反應(yīng)蛋白(hs CRP)、腫瘤壞死因子-α(TNF-α)及白細(xì)胞介素-6(IL-6),并計(jì)算體重指數(shù)(BMI)、胰島素抵抗指數(shù)(HOMA-IR)。采用雙抗體夾心酶聯(lián)免疫吸附實(shí)驗(yàn)(ELISA)檢測所有受試者血清PLGF濃度。結(jié)果:(1)三組比較,T2DM+NAS組、T2DM+AS組血清PLGF水平(45.35±13.00,59.24±11.05)pg/m L均顯著高于NC組(27.30±10.22)pg/m L(P0.01),T2DM+AS組血清PLGF水平顯著高于T2DM+NAS組(P0.01)。(2)三組血清PLGF水平與BMI、SBP、FPG、TC、TG、LDL-C、Hb A1c、hs CRP、TNF-α、IL-6呈正相關(guān)(r分別為0.311、0.266、0.455、0.363、0.260、0.395、0.575、0.396、0.411、0.449,P0.05);T2DM患者血清PLGF水平與TC、LDL-C、hs CRP、IL-6呈顯著正相關(guān)(r分別為0.351、0.387、0.272、0.300,P0.05)。(3)多元線性逐步回歸結(jié)果顯示:LDL-C、IL-6為血清PLGF水平的獨(dú)立影響因素(β=7.226、1.537,P0.05)。(4)Logistic回歸分析顯示PLGF為頸動脈粥樣硬化的風(fēng)險預(yù)測因子。結(jié)論:(1)PLGF在頸動脈正常的T2DM患者血清中表達(dá)已增多,在T2DM合并頸動脈粥樣斑塊的患者血清中表達(dá)進(jìn)一步增多,提示PLGF可能參與了2型糖尿病患者頸動脈粥樣斑塊的早期形成,促進(jìn)了動脈粥樣硬化的發(fā)生、發(fā)展,或可作為2型糖尿病患者預(yù)測頸動脈粥樣硬化的一個早期指標(biāo)。(2)相關(guān)分析顯示PLGF水平與炎癥指標(biāo)hs CRP、TNF-α和IL-6呈正相關(guān),IL-6為PLGF水平獨(dú)立影響因素,提示PLGF可能通過參與炎癥反應(yīng)促進(jìn)2型糖尿病頸動脈粥樣硬化的發(fā)生發(fā)展。(3)血清PLGF水平與BMI、血壓、血糖、血脂均密切相關(guān),良好控制血壓、血糖、血脂,減輕體重或可使T2DM患者血清PLGF水平下降,從而延緩頸動脈粥樣硬化發(fā)展。
[Abstract]:Objective: to investigate the relationship between serum placental growth factor (PLGF) and carotid atherosclerosis (ASA) in patients with type 2 diabetes mellitus (T2DM). To provide a theoretical basis for elucidating its role in the process of carotid atherosclerosis in patients with type 2 diabetes, and to explore its role as an early diagnosis of carotid atherosclerosis and other cardiovascular complications in patients with type 2 diabetes mellitus. The possibility of intervention and therapeutic targets. Methods: according to the results of color Doppler ultrasound examination of bilateral carotid artery, 53 patients with type 2 diabetes mellitus were divided into two groups: T2DM without carotid atherosclerotic plaque group (n = 27), T2DM NAS group (n = 27) with T2DM combined with carotid atherosclerotic plaque group (n = 26) and normal control group (n = 26). Measuring blood pressure, height, weight, Fasting blood glucose (FPG), total cholesterol (TCU), triglyceride (TGN), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), insulin (FINSN), glycosylated hemoglobin (HbAlcn), hypersensitive C-reactive protein (hsCRPN), tumor necrosis factor- 偽 (TNF- 偽) and interleukin-6 (IL-6). Body mass index (BMI) and insulin resistance index (ISI) were calculated. The serum PLGF concentration of all subjects was determined by double antibody sandwich enzyme linked immunosorbent assay (Elisa). 緇撴灉:(1)涓夌粍姣旇緝,T2DM NAS緇，

本文編號：1935166