本文選題：H型高血壓 + 糖尿病��； 參考：《廣東醫(yī)學(xué)》2017年06期

【摘要】：目的觀察H型高血壓合并2型糖尿病患者血漿同型半胱氨酸(Hcy)、胱抑素C(Cyst-C)水平與頸動(dòng)脈內(nèi)膜中層厚度(cIMT)的關(guān)系。方法收集符合入選標(biāo)準(zhǔn)的H型高血壓合并2型糖尿病患者120例,應(yīng)用彩色多普勒超聲檢查儀測(cè)定cIMT,根據(jù)頸動(dòng)脈粥樣硬化的程度分為3組,cIMT正常(cIMT0.9 mm)組、cIMT增厚(0.9 mm≤cIMT1.3 mm)組和頸動(dòng)脈斑塊(cIMT≥1.3 mm)組;按血壓水平分為高血壓1級(jí)(140~159/90~99mmHg)組、高血壓2級(jí)(160~179/100~109 mmHg)組、高血壓3級(jí)(≥180/110 mmHg)組,檢測(cè)并比較3組間患者血糖、血脂、尿素氮、血肌酐、糖化血紅蛋白(HbA_(1C))、血清Hcy、Cyst-C水平,分析血清Hcy、Cyst-C與頸動(dòng)脈cIMT的關(guān)系。結(jié)果 (1)按cIMT分為3組,3組間血糖、血脂、尿素氮、血肌酐等比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),血清Hcy、Cyst-C比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),其水平隨著cIMT增厚而增加;(2)按血壓水平分為3組,高血壓3級(jí)組血清Hcy、Cyst-C水平高于高血壓1級(jí)、2級(jí)組,高血壓2級(jí)組血清Hcy、Cyst-C水平高于高血壓1級(jí)組(均P0.05),其水平隨著血壓水平升高而升高;(3)cIMT與Hcy、Cyst-C、HbA_(1C)、收縮壓、舒張壓呈正相關(guān)(r=0.256、0.358、0.280、0.580、0.306,均P0.05),進(jìn)一步行二分類logistic回歸分析顯示Hcy、Cyst-C、HbA_(1C)、收縮壓是cIMT增厚的獨(dú)立危險(xiǎn)因素(OR=55.257、1.545、3.121、1.154,均P0.05)。結(jié)論 H型高血壓合并2型糖尿病患者血清Hcy、Cyst-C水平與頸動(dòng)脈粥樣硬化具有密切相關(guān)性,是cIMT增厚的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the relationship between plasma homocysteine cystatin Cyst-C and carotid intima-media thickness (IMT) in patients with type H hypertension and type 2 diabetes. Methods 120 patients with H type hypertension and type 2 diabetes mellitus who met the inclusion criteria were collected. According to the degree of carotid atherosclerosis, cIMT was measured by color Doppler ultrasound, and was divided into 3 groups according to the degree of carotid atherosclerosis: the group with normal carotid atherosclerosis (cIMT1.3 0.9 mm) and the group with carotid plaques 鈮，

本文編號(hào)：1926719