本文選題：糖皮質(zhì)激素性骨質(zhì)疏松癥 + 系統(tǒng)性紅斑狼瘡��； 參考：《山東大學學報(醫(yī)學版)》2017年05期

【摘要】：目的觀察骨代謝在糖皮質(zhì)激素性骨質(zhì)疏松癥(GIOP)進展過程中與糖皮質(zhì)激素用藥時間的關系及變化規(guī)律,并依據(jù)骨代謝變化趨勢探討GIOP的防治策略。方法檢測應用GC控制病情的系統(tǒng)紅斑狼瘡患者117例和健康人群21例骨代謝標志物(β-CTX、T-P1NT、N-MIDOs),測定L1-4椎體骨密度。依據(jù)GC使用時間將患者分為7個亞組:Ⅰ組用藥1~6個月,Ⅱ組用藥7~12個月,Ⅲ組用藥13~18個月,Ⅳ組用藥19~24個月,Ⅴ組用藥25~30個月,Ⅵ組用藥31~36個月,Ⅶ組用藥36個月。結果Ⅰ組、Ⅱ組和Ⅲ組β-CTX較正常對照組明顯升高,差異有統(tǒng)計學意義(P0.05);Ⅵ組和Ⅶ組β-CTX較正常對照組明顯減低,差異有統(tǒng)計學意義(P0.05);Ⅳ組和Ⅴ組β-CTX較正常對照組無明顯差異(P0.05);應用GC的各亞組T-P1NT、N-MIDOs均較正常對照組明顯減低,差異有統(tǒng)計學意義(P0.05);Ⅱ~Ⅶ組骨密度較正常對照組明顯減低,差異有統(tǒng)計學意義(P0.05)。結論 GIOP形成過程中,骨代謝是由高分解狀態(tài)向低分解低成骨低轉(zhuǎn)換狀態(tài)轉(zhuǎn)變。應用GC 1~18個月的SLE患者骨代謝狀態(tài)處于高分解低成骨,應用GC 30個月以上的患者骨代謝狀態(tài)處于低分解低成骨低轉(zhuǎn)換狀態(tài)。
[Abstract]:Objective to observe the relationship between bone metabolism and glucocorticoid administration time during the development of glucocorticoid-induced osteoporosis (GIOP) and discuss the prevention and treatment strategy of GIOP according to the trend of bone metabolism. Methods Bone mineral density (BMD) of L1-4 vertebrae was measured in 117 patients with systemic lupus erythematosus and 21 healthy controls. According to the time of GC, the patients were divided into seven subgroups: group 鈪，

本文編號：1912794