本文選題：1型糖尿病 + 糖尿病周圍神經(jīng)病變��； 參考：《蘇州大學(xué)》2015年碩士論文

【摘要】：目的應(yīng)用Neurometer CPT/C神經(jīng)測量儀檢測臨床確診1型糖尿病患者周圍神經(jīng)的電流感覺閾值(CPT),對比分析大小纖維受損的程度,從而為糖尿病周圍神經(jīng)病變(DPN)的早期診斷提供有效證據(jù)。方法完善神經(jīng)癥狀評分(NSS)、神經(jīng)缺陷評分(NDS)及感覺神經(jīng)傳導(dǎo)速度(SCV)檢查,選取其中NSS、NDS、SCV均正常且病程小于5年的52例1型糖尿病患者,測定52例患者及40例健康對照組的雙側(cè)正中神經(jīng)、腓腸神經(jīng)于2000Hz、250Hz、5Hz的CPT值,并檢測患者組的糖化血紅蛋白、尿微量白蛋白、尿微量白蛋白肌酐比等代謝指標(biāo)。結(jié)果與健康對照組比較,糖尿病組患者雙側(cè)正中神經(jīng)及腓腸神經(jīng)在各頻率下的CPT值均明顯降低(P0.01),糖尿病組正中神經(jīng)損傷數(shù)量(左側(cè)8/52,右側(cè)8/52)與同側(cè)腓腸神經(jīng)損傷數(shù)量(左側(cè)28/52,右側(cè)22/52)比較存在顯著差異(左右側(cè)均P0.01);糖尿病組中存在DPN組與未發(fā)生DPN組比較,DPN組的糖化血紅蛋白比未發(fā)生DPN組較高(t=2.518,P0.05),運用二元logistic回歸發(fā)現(xiàn),高糖化血紅蛋白是DPN的一個獨立危險因素(OR(95%CI):1.317(1.013-1.712),P0.05)。結(jié)論電流感覺閾值(CPT)可以早期發(fā)現(xiàn)1型糖尿病發(fā)生周圍神經(jīng)病變的高危患者,同時糖尿病周圍神經(jīng)病變中下肢神經(jīng)較上肢神經(jīng)易損,發(fā)生DPN患者糖化血紅蛋白較高,且高糖化血紅蛋白是DPN的一個獨立危險因素。
[Abstract]:Objective to detect the current sensation threshold of peripheral nerve in type 1 diabetic patients by using Neurometer CPT/C neurometer, and to compare and analyze the extent of the damage of large and small fibers, so as to provide effective evidence for the early diagnosis of diabetic peripheral neuropathy. Methods the neurological symptom score (NSS), nerve defect score (NDS) and sensory nerve conduction velocity (SCV) were improved. Among them, 52 patients with type 1 diabetes with normal NSSN NDSU SCV and less than 5 years course of disease were selected. The CPT values of bilateral median nerve and sural nerve were measured in 52 patients and 40 healthy controls at 2000Hz, 250Hz / 5Hz, and the metabolic indexes such as glycosylated hemoglobin and urinary albumin creatinine ratio were measured. Results compared with the healthy control group, The CPT values of bilateral median nerve and sural nerve in diabetic group were significantly lower than those of control group (left 8 / 52, right 8 / 52) and ipsilateral sural nerve (left 28 / 52, right 22 / 52). There were significant differences between the right and left sides (P 0.01), the glycosylated hemoglobin in the diabetic group with DPN was higher than that in the DPN group (P 0.05). The results were found by binary logistic regression. High glycosylated hemoglobin is an independent risk factor for DPN. Conclusion the high risk patients with peripheral neuropathy in type 1 diabetes can be detected early by current sensing threshold (CPT). The lower extremity nerves of diabetic peripheral neuropathy are more vulnerable than those of upper limb nerves, and the patients with DPN have higher glycosylated hemoglobin. And high glycosylated hemoglobin is an independent risk factor for DPN.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 劉明生,胡蓓蕾,崔麗英,湯曉芙,杜華,李本紅;糖尿病周圍神經(jīng)病700例臨床與神經(jīng)電生理分析[J];中華內(nèi)科雜志;2005年03期

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本文編號：1907025