本文選題：百草枯 + 中毒�。� 參考：《西南醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究百草枯(paraquat,PQ)中毒所致肺損傷的胸部CT表現(xiàn),提高對百草枯中毒的認識。方法:回顧性對比與分析122例百草枯中毒患者的臨床與胸部CT表現(xiàn),按中毒劑量[1]將患者分為少量組(10 ml)46例、中量組(11~50 ml)56例、大量組(50 ml)20例,按病程[1]將患者分為早期(1~7 d)、中期(8~14 d)、晚期(14 d以后)三組,通過對比不同組的CT表現(xiàn)同劑量與時間的關(guān)系、分析病變分布范圍,總結(jié)百草枯中毒的影像學(xué)特點。結(jié)果:隨著時間進展[1],百草枯中毒患者胸部CT具有特征性,早期表現(xiàn)為肺紋理增多、磨玻璃征,然后逐漸出現(xiàn)滲出實變,最后肺纖維化[1],并且與中毒劑量相關(guān)(P0.05);肺內(nèi)滲出與實變病灶主要分布于雙肺野外帶,為臨床診療提供依據(jù)。結(jié)論:百草枯中毒肺損傷的胸部CT所見病變轉(zhuǎn)變過程有一定特征性[1],其損傷程度與劑量、時間相關(guān),對臨床診療具有十分重要的意義[1]。目的:建立急性百草枯中毒肺損傷大鼠模型,為進一步探討百草枯的中毒機制和治療效果奠定基礎(chǔ)。方法:SD大鼠共60只,雌雄各半,隨機分為3個實驗組和1個對照組,每組15只,分別給大鼠一次性腹腔注射不同劑量的百草枯溶液,對照組一次性腹腔注射等體積的無菌等滲鹽水,每天觀察大鼠中毒癥狀及CT表現(xiàn),并于1、3、7、14、21 d分別處死3只實驗組及對照組大鼠,取大鼠右下葉肺組織做病理切片染色觀察。結(jié)果:一次性腹腔注射不同劑量(40 mg/kg、60 mg/kg、80 mg/kg)的百草枯溶液后,大鼠在不同時間段出現(xiàn)了不同程度的中毒癥狀,光鏡下可觀察到大鼠百草枯中毒后肺損傷的病理演變過程。結(jié)論:百草枯對大鼠具有強毒性,一次性腹腔注射百草枯溶液,可成功建立肺損傷模型。
[Abstract]:Objective: to study the chest CT findings of lung injury caused by paraquat PQQ poisoning and to improve the understanding of paraquat poisoning. Methods: the clinical and thoracic CT findings of 122 paraquat poisoning patients were retrospectively compared and analyzed. According to the dose of poisoning [1], the patients were divided into a small group of 10 ml)46, a moderate dose group of 1150 cases and a large number of patients with 50 ml)20. According to the course of disease [1], the patients were divided into three groups: early stage (1 day), middle stage (814 d), late stage (14 d). By comparing CT findings of different groups with the same dose and time, the range of lesion distribution was analyzed and the imaging features of paraquat poisoning were summarized. Results: with the development of time, the chest CT of paraquat poisoning patients was characterized by the increase of lung texture, grinding of glass sign, and then the appearance of exudation and consolidation. Finally, pulmonary fibrosis was found [1], which was related to the dose of poisoning (P0.05). The focus of exudation and consolidation in the lung was mainly distributed in the field zone of both lungs, which provided the basis for clinical diagnosis and treatment. Conclusion: the change process of chest CT findings of paraquat poisoning lung injury is characteristic [1]. The degree of injury is correlated with dose and time, which is of great significance for clinical diagnosis and treatment. Objective: to establish a rat model of acute paraquat poisoning and to establish a foundation for further study on the mechanism and therapeutic effect of paraquat poisoning. Methods Sixty Sprague-Dawley rats, half male and half male, were randomly divided into 3 experimental groups and 1 control group, 15 rats in each group were injected with paraquat solution in a single dose. The rats in the control group were injected intraperitoneally with iso-osmotic saline of the same volume once a day. The toxic symptoms and CT findings of the rats were observed every day. Three rats in the experimental group and the control group were killed for 21 days. The lung tissue of the right lower lobe of the rats was stained with pathological sections. Results: after intraperitoneal injection of different doses of 40 mg / kg ~ 60 mg / kg ~ (80 mg 路kg ~ (-1) paraquat solution, the rats showed different degrees of poisoning symptoms in different time periods. The pathological process of lung injury after paraquat poisoning in rats was observed under light microscope. Conclusion: paraquat has strong toxicity to rats. Once intraperitoneal injection of paraquat solution can successfully establish lung injury model.
【學(xué)位授予單位】：西南醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R595.4;R816.41

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