本文選題：型糖尿病 + 下肢病變�。� 參考：《中國老年學(xué)雜志》2017年07期

【摘要】：目的探討彩色多普勒超聲檢查結(jié)果與2型糖尿病(T2DM)下肢病變患者血清生化指標(biāo)的相關(guān)性。方法 T2DM患者80例,依據(jù)有無下肢血管病變分為T2DM對照(T2DM-C)組38例和T2DM觀察(T2DM-O)組42例,另選該院健康體檢者40例為對照組。所有受試者接受彩色多普勒超聲檢查,測量股動脈、乆動脈內(nèi)-中膜復(fù)合體厚度(IMT)和粥樣斑塊數(shù);采集靜脈血檢測血清中C反應(yīng)蛋白(CRP)、25羥維生素D3〔25(OH)D3〕,并分析上述指標(biāo)與股動脈、乆動脈IMT的相關(guān)性。結(jié)果 T2DM-O組CRP水平均顯著高于T2DM-C組和對照組,T2DM-O組25(OH)D3均顯著低于T2DM-C組和對照組,T2DM-C組CRP水平高于對照組,25(OH)D3水平低于對照組(均P0.05);T2DM患者頸動脈和乆動脈IMT均顯著高于對照組,且T2DM-O組顯著高于T2DM-C組(均P0.05);T2DM患者斑塊陽性率顯著高于對照組,且T2DM-O組顯著高于T2DM-C組(均P0.05);T2DM患者動脈IMT與血清CRP水平呈正相關(guān),與25(OH)D3水平呈負(fù)相關(guān)(均P0.05)。結(jié)論 T2DM患者下肢動脈IMT增加與血清指標(biāo)異常存在顯著相關(guān)性,可以據(jù)此判斷疾病的發(fā)生、發(fā)展情況,采取預(yù)防和治療措施,改善預(yù)后。
[Abstract]:Objective to investigate the correlation between the results of color Doppler ultrasonography and serum biochemical indexes in patients with type 2 diabetes mellitus (T2DM). Methods Eighty patients with T2DM were divided into T2DM control group (38 cases) and T2DM observation group (42 cases). All subjects were examined by color Doppler ultrasound to measure the femoral artery, IMT and the number of atherosclerotic plaques. The correlation between the above indexes and femoral artery and IMT of femoral artery was analyzed. Results the level of CRP in T2DM-O group was significantly higher than that in T2DM-C group and control group. The 25(OH)D3 level in T2DM-O group was significantly lower than that in T2DM-C group and control group. The level of CRP in T2DM-C group was significantly higher than that in control group. The plaque positive rate in T2DM-O group was significantly higher than that in T2DM-C group (P 0.05) and in T2DM-O group was significantly higher than that in T2DM-C group (P 0.05). There was a positive correlation between arterial IMT and serum CRP level, and a negative correlation between IMT and 25(OH)D3 level (all P 0.05). Conclusion there is a significant correlation between the increase of IMT in lower extremity artery and abnormal serum index in patients with T2DM, which can be used to judge the occurrence and development of the disease, and to take preventive and therapeutic measures to improve the prognosis.
【作者單位】： 儋州市第一人民醫(yī)院內(nèi)分泌科;
【分類號】：R587.2

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