本文選題：鋅缺乏 + 體脂��； 參考：《衛(wèi)生研究》2017年03期

【摘要】：目的觀察邊緣性鋅缺乏對大鼠肥胖的影響。方法 SPF級成年雄性SD大鼠32只,隨機分為4組,低鋅組喂飼含6 mg/kg鋅的邊緣性鋅缺乏飼料,中鋅組喂飼含10 mg/kg鋅的邊緣性鋅缺乏飼料,低鋅對飼組和對照組喂飼正常鋅含量的AIN-93M飼料。喂養(yǎng)6周后,處死動物。測血鋅、血脂、血清瘦素含量,肝臟總抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。結果低鋅組大鼠第5周起血鋅含量明顯低于低鋅對飼組和對照組(P0.05),成功建立邊緣性缺鋅模型。第6周時,低鋅組大鼠脂體比明顯高于低鋅對飼組和對照組(P0.05);低鋅組和中鋅組大鼠肝臟MDA含量明顯高于對照組(P0.05);低鋅組和中鋅組大鼠肝臟TAOC、SOD水平明顯低于對照組(P0.05)。結論邊緣性鋅缺乏可增加肥胖發(fā)生的風險,缺鋅組大鼠體內氧化應激升高可能是邊緣性鋅缺乏增加肥胖風險的主要原因。
[Abstract]:Objective to observe the effect of marginal zinc deficiency on obesity in rats. Methods Thirty-two adult male SD rats of SPF grade were randomly divided into 4 groups. The low zinc group was fed with marginal zinc deficiency diet containing 6 mg/kg zinc, while the middle zinc group was fed with 10 mg/kg zinc borderline zinc deficiency diet. Low zinc group and control group were fed with AIN-93M diet with normal zinc content. After 6 weeks of feeding, the animals were killed. The levels of serum zinc, serum lipid, serum leptin, total antioxidant capacity of liver, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. Results the serum zinc content in the low zinc group was significantly lower than that in the low zinc feeding group and the control group from the 5th week, and the marginal zinc deficiency model was successfully established. At the 6th week, the lipid body ratio of the rats in the low zinc group was significantly higher than that in the low zinc feeding group and the control group (P 0.05), the MDA content in the liver of the low zinc group and the middle zinc group was significantly higher than that of the control group (P 0.05), and the level of TAOCU SOD in the liver of the low zinc group and the middle zinc group was significantly lower than that of the control group (P 0.05). Conclusion Peripheral zinc deficiency can increase the risk of obesity. The increase of oxidative stress in rats with zinc deficiency may be the main reason for increasing the risk of obesity.
【作者單位】： 中國疾病預防控制中心營養(yǎng)與健康所國家衛(wèi)生計生委微量元素營養(yǎng)重點實驗室;
【基金】：國家自然科學基金(No.81273073)
【分類號】：R589.2

【相似文獻】

相關期刊論文 前10條

1 沈杰;張?zhí)靾@;;成年人鋅缺乏狀況調查分析[J];微量元素與健康研究;2009年02期

2 呂傳真,陸費漢倩,吳之],邱燕惠;鋅缺乏1例報告[J];中國神經精神疾病雜志;1983年01期

3 宋迎春;嬰幼兒鋅缺乏[J];國外醫(yī)學(醫(yī)學地理分冊);1997年03期

4 康惠敏;鋅缺乏對腦發(fā)育及神經系統(tǒng)的影響[J];臨床薈萃;1997年21期

5 李洪波;鋅缺乏與營養(yǎng)不良[J];國外醫(yī)學(醫(yī)學地理分冊);2002年03期

6 王佐周;高慧玲;徐赫;王濤;王占友;;鋅缺乏對小鼠海馬長時程增強的影響[J];解剖科學進展;2011年03期

7 單延春,盛曉陽,陳宏新,洪昭毅;鋅缺乏對生長期大鼠外周血淋巴細胞表型及亞群分布的影響[J];營養(yǎng)學報;2002年04期

8 祁秀敏,徐小虎,于曉軍;鋅缺乏與免疫功能的研究進展[J];衛(wèi)生研究;2004年04期

9 馬麗英,王瑞淑,李云;鋅缺乏和鋅過量對小鼠胚胎長骨發(fā)育的影響[J];衛(wèi)生毒理學雜志;1999年02期

10 艾華，，陳吉棣，賀師鵬;鋅缺乏對大鼠骨骼肌α－肌動蛋白基因表達的影響[J];營養(yǎng)學報;1996年01期

相關碩士學位論文 前1條

1 葉放;鋅缺乏導致小鼠骨骼發(fā)育障礙與鋅轉運蛋白異常[D];中國醫(yī)科大學;2008年

本文編號：1872855