本文選題：碘營(yíng)養(yǎng) + 甲狀腺功能亢進(jìn)癥�。� 參考：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:了解山西地區(qū)成年人群目前的碘營(yíng)養(yǎng)狀況,以及甲狀腺疾病的患病情況,探討碘攝入與甲狀腺疾病之間的相關(guān)性。方法:本研究采用隨機(jī)抽樣的方法,按照入選標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn),共選取參與2015年山西地區(qū)甲狀腺疾病調(diào)查的2479名健康體檢者(其中城市人群1322人、農(nóng)村人群1157人),全部受試者均進(jìn)行問(wèn)卷調(diào)查、體檢、采集血標(biāo)本測(cè)定甲狀腺功能、留取晨尿用于尿碘測(cè)定、甲狀腺超聲檢查。調(diào)查對(duì)象的基本信息及化驗(yàn)結(jié)果全部錄入數(shù)據(jù)庫(kù),整理、分析實(shí)驗(yàn)數(shù)據(jù)。結(jié)果:1.山西地區(qū)成人MUI為214.7ug/L,男性MUI明顯高于女性(220.5ug/L vs205.6ug/L),差異具有統(tǒng)計(jì)學(xué)意義(P=0.037)。青年組MUI高于中年組(224.7 ug/L vs 203.6 ug/L),中年組高于老年組(203.6 ug/L vs 185.5 ug/L),三組人群的MUI經(jīng)秩和檢驗(yàn),P0.001,差異具有統(tǒng)計(jì)學(xué)意義。城市成人MUI(186.2ug/L)明顯低于農(nóng)村成人MUI(245.7ug/L),差異具有統(tǒng)計(jì)學(xué)意義(P0.001)。2.甲狀腺疾病患病率分別為:甲減(0.6%)、亞臨床甲減(15.7%)、甲亢(0.5%)、亞臨床甲亢(0.7%)及甲狀腺結(jié)節(jié)(9.9%)。城市人群甲狀腺結(jié)節(jié)患病率(12.1%)明顯高于農(nóng)村的甲狀腺結(jié)節(jié)患病率(7.7%),差異具有統(tǒng)計(jì)學(xué)意義。城市人群甲減、亞臨床甲減、甲亢、亞臨床甲亢患病率,與農(nóng)村相比,差異無(wú)統(tǒng)計(jì)學(xué)意義。3.不同碘營(yíng)養(yǎng)組TPOAb陽(yáng)性率及TPOAb和TGAb均陽(yáng)性率之間差異無(wú)統(tǒng)計(jì)學(xué)意義,而TSH水平及TGAb陽(yáng)性率之間差異具有統(tǒng)計(jì)學(xué)意義。不同碘營(yíng)養(yǎng)組甲減、亞甲減、甲亢、亞甲亢及甲狀腺結(jié)節(jié)的患病率之間,差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論:1.山西地區(qū)成人碘水平基本處于碘超足量的狀態(tài)。2.不同碘營(yíng)養(yǎng)組之間,TPOAb陽(yáng)性率差異無(wú)統(tǒng)計(jì)學(xué)意義,TSH水平及TGAb陽(yáng)性率差異具有統(tǒng)計(jì)學(xué)差異,碘超足量水平的TSH水平及TGAb的陽(yáng)性率最低。不同碘水平組間甲狀腺疾病的患病率沒(méi)有統(tǒng)計(jì)學(xué)差異。
[Abstract]:Objective: to investigate the iodine nutritional status of adult population and the prevalence of thyroid disease in Shanxi province and to explore the correlation between iodine intake and thyroid disease. Methods: according to the inclusion criteria and exclusion criteria, a total of 2479 healthy people (including 1322 urban residents) who participated in the investigation of thyroid diseases in Shanxi in 2015 were selected by random sampling. 1157 people from rural areas were investigated by questionnaire, physical examination, blood samples were collected to determine thyroid function, morning urine was reserved for urine iodine determination, and thyroid ultrasound examination was performed. The basic information and test results of the subjects were entered into the database, collated and analyzed the experimental data. The result is 1: 1. The MUI of adults in Shanxi area was 214.7ugP / L, and the MUI of males was significantly higher than that of females (220.5ugP / L vs 205.6ugP / L), and the difference was statistically significant (0.037g / L). The MUI of the young group was higher than that of the middle-aged group (224.7 ug/L vs 203.6 ugP / L), and that of the middle-aged group was higher than that of the elderly group (203.6 ug/L vs 185.5 ugr / L). The MUI of the three groups was significantly higher than that of the middle age group by rank sum test (P 0.001). Urban adults (186.2ugr / L) were significantly lower than rural adults (245.7ugP / L). The difference was statistically significant (P 0.001g / L). The prevalence rates of thyroid diseases were as follows: hypothyroidism 0.6, subclinical hypothyroidism 15.7m, hyperthyroidism 0.5, subclinical hyperthyroidism 0.7) and thyroid nodule 0.9. The prevalence of thyroid nodules in urban population was significantly higher than that in rural areas (P < 0.01). The prevalence of hypothyroidism, subclinical hypothyroidism, hyperthyroidism and subclinical hyperthyroidism in urban population was not significantly different from that in rural areas. There was no significant difference in TPOAb positive rate, TPOAb and TGAb positive rate between different iodine nutrition groups, but there was significant difference between TSH level and TGAb positive rate. There was no significant difference in the prevalence of hypothyroidism, hypothyroidism, hyperthyroidism and thyroid nodule in different iodine nutrition groups. Conclusion 1. The adult iodine level in Shanxi area is basically in the state of iodine excess. There was no significant difference in the positive rate of TPOAb and TGAb between different iodine nutrition groups. The level of TSH and the positive rate of TGAb were the lowest at the level of iodine excess. There was no significant difference in the prevalence of thyroid disease among groups with different iodine levels.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R581

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