本文選題：認(rèn)知功能障礙 + 腦白質(zhì)微結(jié)構(gòu)��； 參考：《山東醫(yī)藥》2017年43期

【摘要】：目的探討新確診的2型糖尿病(T2DM)和糖耐量減低(IGT)患者是否存在認(rèn)知功能障礙和腦白質(zhì)微結(jié)構(gòu)改變及二者是否有關(guān)。方法新確診的T2DM患者20例(T2DM組)、新確診的IGT患者18例(IGT組)、正常人17例(正常組),接受蒙特利爾量表(Mo CA)評分及腦白質(zhì)磁共振彌散張量成像(DTI)檢查[得到各向異性(FA)值],分析Mo CA評分與FA值的相關(guān)性。結(jié)果 T2DM組、IGT組、正常組的Mo CA評分分別為(24.78±2.42)、(26.12±1.47)、(27.16±2.21)分;組間相比,P0.01;T2DM組與IGT組、正常組相比,P均0.05;IGT組與正常組相比,P0.05。T2DM組、IGT組、正常組的左側(cè)腦白質(zhì)FA值(FAl)分別為0.457 8±0.020 1、0.472 3±0.018 2、0.487 6±0.020 0;組間相比,P0.01;T2DM組與IGT組、正常組相比,P均0.05;IGT組與正常組相比,P0.05。T2DM組、IGT組、正常組的右側(cè)腦白質(zhì)FA值(FAr)分別為0.469 8±0.019 3、0.481 7±0.036 8、0.492 7±0.022 4;組間相比,P0.05;T2DM組與IGT組、正常組相比,P均0.05;IGT組與正常組相比,P0.05。T2DM組Mo CA評分與FAl呈正相關(guān)(r=0.432,P0.05),與FAr無相關(guān)關(guān)系(r=0.605,P0.05)。結(jié)論新確診的T2DM患者可能已經(jīng)存輕度認(rèn)知功能障礙及腦白質(zhì)微結(jié)構(gòu)改變,而新確診的IGT患者的認(rèn)知功能和腦白質(zhì)微結(jié)構(gòu)可能尚未出現(xiàn)改變;新確診的T2DM患者左側(cè)腦白質(zhì)微結(jié)構(gòu)的改變可能對認(rèn)知功能下降有一定影響。
[Abstract]:Objective to investigate whether the patients with newly diagnosed type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) have cognitive impairment and white matter microstructural changes and whether there is a correlation between the two. Methods Twenty newly diagnosed T2DM patients with T2DM, 18 patients with newly diagnosed IGT and 17 normal subjects (normal group, received the Montreal scale of Mo CA) and white matter magnetic resonance diffusion Zhang Liang imaging (DTI) were examined. The correlation between Mo CA score and FA value was analyzed. Results the scores of Mo CA in T2DM group and normal group were 24.78 鹵2.42, 26.12 鹵1.47, 27.16 鹵2.21, P 0.01 and IGT, respectively. The FA values of left white matter in normal group were 0.457 8 鹵0.020 1,0.472 3 鹵0.018 2n 0.487 6 鹵0.020 0, respectively, compared with P0.01T2DM group and IGT group, and the comparison between normal group and normal group was compared with that of normal group, and the difference between normal group and normal group was significantly higher than that in normal group (P < 0.05), and that in normal group was significantly higher than that in normal group (P < 0.05). The FA value of right white matter in normal group was 0.469 8 鹵0.019 3 鹵0 481 7 鹵0.036 8 鹵0 492 7 鹵0.022 4 respectively, and there was no significant correlation between normal group and normal group (P 0. 05%) and normal group (P 0. 05%, P < 0 05). There was a positive correlation between Mo CA score and FAl in normal group (P 0. 05) and no correlation with FAr (r 0. 605 P 0. 05). Conclusion the newly diagnosed patients with T2DM may already have mild cognitive impairment and white matter microstructural changes, while the newly diagnosed IGT patients may not have any changes in cognitive function and white matter microstructure. The changes of left white matter microstructures in newly diagnosed T2DM patients may have an effect on cognitive impairment.
【作者單位】： 鄭州大學(xué)第二附屬醫(yī)院;
【基金】：河南省高等學(xué)校重點(diǎn)科研項(xiàng)目(17A320039)
【分類號】：R587.2

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 姜靜;楊繼芹;季永生;;血糖控制未達(dá)標(biāo)對2型糖尿病合并腦白質(zhì)病變患者的影響[J];寧夏醫(yī)學(xué)雜志;2014年09期

2 余勤,秦貴軍,劉新鄭,王守俊,白悅心,董義光;182例糖耐量減低患者三年演變[J];中國糖尿病雜志;2002年06期

3 吳志香;;糖耐量減低的干預(yù)治療[J];中國實(shí)用鄉(xiāng)村醫(yī)生雜志;2006年12期

4 王慧;林紅軍;;頸動(dòng)脈內(nèi)中膜厚度與糖耐量減低的相關(guān)性研究[J];南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版);2011年03期

5 沈權(quán)民;;警惕糖耐量減低[J];養(yǎng)生月刊;2013年05期

6 蔣麗珍,張木勛;糖耐量減低的干預(yù)治療[J];中國實(shí)用內(nèi)科雜志;2001年05期

7 賈建厚 ,喬青寧 ,王安純 ,張淑榮 ,李允 ,王梅芳 ,沙寧 ,鄒曉春 ,施秉銀;糖耐量減低的臨床分析研究[J];遼寧實(shí)用糖尿病雜志;2001年03期

8 李靜云;糖耐量減低人群的干預(yù)治療[J];護(hù)理研究;2001年03期

9 胡鳳楠;什么疾病和狀態(tài)會(huì)發(fā)生糖耐量減低[J];實(shí)用鄉(xiāng)村醫(yī)生雜志;2002年06期

10 陳學(xué)梅,林恒;關(guān)注糖耐量減低 農(nóng)村更重要[J];中國實(shí)用鄉(xiāng)村醫(yī)生雜志;2004年08期

相關(guān)會(huì)議論文 前10條

1 朱華;周勁峰;沈俊婭;;糖耐量減低患者糖化血紅蛋白的變化及其意義[A];2006年浙江省檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)年會(huì)論文匯編[C];2006年

2 徐積兄;劉建英;李雯霞;朱凌燕;昌玉蘭;;糖耐量減低者體內(nèi)存在高水平的氧化應(yīng)激[A];江西省首屆中西醫(yī)結(jié)合內(nèi)分泌專業(yè)學(xué)術(shù)交流會(huì)論文資料匯編[C];2010年

3 穆s，

本文編號：1835444