本文選題：高糖毒性 + 平衡�。� 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年27期

【摘要】：目的探討胰島素不同使用途徑短期解除高糖毒性后,對老年2型糖尿病患者平衡功能的影響。方法將符合納入標(biāo)準(zhǔn)的98例老年2型糖尿病(T2DM)患者作為研究對象,隨機分為A組(50例)和B組(48例),A組使用短期持續(xù)性皮下胰島素泵,B組為多次胰島素皮下注射,通過計時起立-步行測試(TUGT)、單腿站立測試(OLST)來評估患者的動態(tài)平衡能力、靜態(tài)平衡能力,5次坐立測試(FTSST)評估下肢肌力,比較兩組治療前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、TUGT、OLST(睜)、OLST(閉)、FTSST測試值的變化。結(jié)果治療2周后,同干預(yù)前比較,兩組FPG、2 h PG、TUGT、OLST(睜)值均有所改善(P0.05),且A組的TUGT、OLST(睜)值優(yōu)于B組(P0.05),而OLST(閉)、FTSST值前后改善不大,差異無統(tǒng)計學(xué)意義(P0.05);TUGT值與年齡、病程、Hb A1c、2 h PG、FTSST值呈正相關(guān)(P0.05),與OLST(睜)、OLST(閉)值呈負(fù)相關(guān)(P0.05);OLST(睜)值與年齡、FPG、TUGT、FTSST值呈負(fù)相關(guān)(P0.05),與OLST(閉)值呈正相關(guān)(P0.05)。結(jié)論通過不同胰島素使用途徑特別是胰島素泵短期解除高糖毒性后,均可改善老年2型糖尿病患者的動態(tài)平衡能力及睜眼時靜態(tài)平衡能力,降低發(fā)生跌倒的風(fēng)險。
[Abstract]:Objective to investigate the effect of insulin on the balance function of elderly patients with type 2 diabetes after the different use of insulin in the short term. Methods 98 elderly patients with type 2 diabetes (T2DM) were selected as subjects and were randomly divided into group A (50 cases) and group B (48 cases). The A group used a short-term continuous subcutaneous insulin pump, and the B group was multiple times. Subcutaneous insulin injection was used to evaluate the patient's dynamic balance ability, static balance ability, 5 standing test (FTSST) assessment of lower limb muscle strength by time standing test (TUGT), single leg standing test (OLST), compared the fasting blood glucose (FPG), postprandial 2 h blood glucose (2 h PG), TUGT, OLST (open), OLST (closed), FTSST test values of the two groups before and after treatment. Results after 2 weeks of treatment, the two groups of FPG, 2 h PG, TUGT and OLST were all improved (P0.05) before the treatment, and the TUGT of the A group was better than the B group (P0.05), and OLST (closed) was not significant before and after the value. The value of closed) was negatively correlated (P0.05); the value of OLST (open) was negatively correlated with age, FPG, TUGT, FTSST value (P0.05) and positively correlated with the value of OLST (closed). Conclusion the dynamic balance ability and static balance ability of the elderly patients with type 2 diabetes can be improved by using different insulin use methods, especially the insulin pump to relieve the high glucose toxicity in the short term. Reduce the risk of falling.

【作者單位】： 新鄉(xiāng)醫(yī)學(xué)院;河南省人民醫(yī)院內(nèi)分泌科;
【基金】：河南省科技廳科技攻關(guān)項目(No:132102310466)
【分類號】：R587.1

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