本文選題：代謝綜合征X + 體重增長　； 參考：《中國全科醫(yī)學(xué)》2017年17期

【摘要】：背景體質(zhì)量與代謝綜合征(MS)有密切聯(lián)系,而體質(zhì)量變化與MS發(fā)病的關(guān)聯(lián)也逐漸受到關(guān)注。目的通過對社區(qū)居民進行3年的隨訪調(diào)查,探討體質(zhì)量變化與MS發(fā)病風(fēng)險的關(guān)系。方法選取2011年參加"中國2型糖尿病患者腫瘤發(fā)生風(fēng)險的流行病學(xué)研究"的貴陽市城區(qū)40歲及以上居民5 850例為研究對象。測量身高、體質(zhì)量、腰圍、血壓,檢測空腹血糖(FPG)、高密度脂蛋白膽固醇(HDL-C)、三酰甘油(TG)水平。于2014年12月,重復(fù)測量上述指標(biāo),計算各指標(biāo)變化的差值,并診斷出隨訪中的MS發(fā)病者。根據(jù)隨訪期間體質(zhì)量變化,將受試者分為5組,即體質(zhì)量減輕(WL)組(減輕≥1.0 kg)、體質(zhì)量穩(wěn)定(WS)組(變化1.0 kg)、體質(zhì)量增加(WG)-A組(增加1.0~2.5 kg)、WG-B組(增加2.5~5.0 kg)、WG-C組(增加WG≥5.0 kg)。結(jié)果本研究共完整隨訪4 392例,失訪率24.92%。男性MS發(fā)病率為15.87%(223/1 405),低于女性MS發(fā)病率的27.18%(812/2 978)(χ2=55.293,P0.05)。隨著不同性別受試者體質(zhì)量變化的增加,MS發(fā)病率呈增長趨勢(P0.05)。各組男性受試者隨訪期間體質(zhì)指數(shù)(BMI)、腰圍、腰圍身高比變化比較,差異均有統(tǒng)計學(xué)意義(P0.05)。各組女性受試者隨訪期間BMI、腰圍、腰圍身高比、收縮壓(SBP)、舒張壓(DBP)變化比較,差異均有統(tǒng)計學(xué)意義(P0.05)。調(diào)整基線年齡、BMI、腰圍、SBP、DBP、FPG、HDL-C、TG水平后,多因素Logistic回歸分析顯示,在男性受試者中,與WS組比較,WL組發(fā)生MS的風(fēng)險降低[OR=0.411,95%CI(0.262,0.645)],WG-B組[OR=2.735,95%CI(1.664,4.497)]、WG-C組[OR=3.755,95%CI(1.907,7.395)]發(fā)生MS的風(fēng)險升高(P0.05);在女性受試者中,與WS組比較,WL組發(fā)生MS風(fēng)險降低[OR=0.675,95%CI(0.534,0.854)],WG-A組[OR=1.446,95%CI(1.125,1.859)]、WG-B組[OR=1.778,95%CI(1.355,2.331)]、WG-C組[OR=2.801,95%CI(1.975,3.972)]發(fā)生MS的風(fēng)險升高(P0.05)。結(jié)論貴陽城區(qū)40歲及以上女性居民MS發(fā)病率高于男性;體質(zhì)量的增長是MS發(fā)病的危險因素;男性在MS發(fā)病過程中對體質(zhì)量的增長較女性敏感。
[Abstract]:Background there is a close relationship between body mass and metabolic syndrome (MSM). Objective to investigate the relationship between the body mass change and the risk of MS. Methods 5850 residents aged 40 years and above in Guiyang City in 2011 were enrolled in the Epidemiological study on Cancer risk of Type 2 Diabetes Mellitus in China. Height, body mass, waist circumference, blood pressure, fasting blood glucose (FPG), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) were measured. In December 2014, the above indexes were measured repeatedly, the differences of the changes were calculated, and the patients with MS were diagnosed. According to the changes of body mass during the follow-up, the subjects were divided into five groups, I. e., the body weight reduction group (鈮，

本文編號：1818858