本文選題：體成分 + 骨密度　； 參考：《中國骨質(zhì)疏松雜志》2017年08期

【摘要】：目的探討絕經(jīng)后婦女血肌肉生長抑制素與體成份、血脂及骨密度的關(guān)系。方法納入175名年齡在51~75歲的絕經(jīng)后婦女,用雙能X線吸收儀測量其骨密度(bone mineral density,BMD)及體成分。酶聯(lián)免疫吸附法測定其血清肌肉生長抑制素、25羥維生素D3、甲狀旁腺激素(parathyroid hormone,PTH)、骨堿性磷酸酶(bone alkaline phosphatase,BAP)、I型膠原C末端肽(type I collagen C terminal peptide,CTX)。結(jié)果與骨質(zhì)疏松者相比,無骨質(zhì)疏松的婦女體重指數(shù)、肥體重及瘦體重更高(P0.01)。骨質(zhì)疏松婦女年齡顯著大于無骨質(zhì)疏松婦女(P0.01)。經(jīng)年齡校正后,兩組之間血BAP、CTX、25羥維生素D3、PTH、血脂成分及肌肉生長抑制素差異無統(tǒng)計學(xué)意義。所有測定部位BMD均與絕經(jīng)年齡、肥體重及瘦體重成正比,與年齡、血BAP成反比。肌肉生長抑制素與血甘油三酯成負(fù)相關(guān)(β=-0.203,P=0.007),與體成分及所有部位骨密度無相關(guān)。結(jié)論研究數(shù)據(jù)表明血肌肉生長抑制素濃度與肌肉量及骨量無相關(guān),需進(jìn)一步研究闡明肌肉生長抑制素在調(diào)節(jié)骨代謝中的作用。
[Abstract]:Objective to investigate the relationship between serum myostatin, body composition, blood lipid and bone mineral density (BMD) in postmenopausal women. Methods 175 postmenopausal women aged 51 to 75 years were enrolled and their bone mineral density and body composition were measured by dual energy X-ray absorptiometry. Serum myostatin 25 hydroxyvitamin D3, parathyroid hormonePTH, bone alkaline phosphatase I collagen C terminal peptide type I collagen C terminal peptidea CTX were determined by enzyme-linked immunosorbent assay (Elisa). Results compared with osteoporosis women without osteoporosis had higher body mass index (BMI) fat weight and lean weight (P 0.01). The age of osteoporosis women was significantly higher than that of women without osteoporosis (P 0.01). After age correction, there was no significant difference between the two groups in blood BAPX CTX 25 hydroxyvitamin D 3 PTH, blood lipid composition and muscle growth inhibitor. BMD of all sites were proportional to menopausal age, fat weight and lean body weight, and inversely to age and blood BAP. There was a negative correlation between myostatin and serum triglyceride (尾 -0.203), but no correlation with body composition and bone mineral density (BMD). Conclusion there is no correlation between the concentration of blood muscle growth inhibitor and the amount of bone and muscle mass. It is necessary to further study the role of muscle growth inhibitor in regulating bone metabolism.
【作者單位】： 南方醫(yī)科大學(xué)附屬小欖醫(yī)院體檢中心;中山火炬開發(fā)區(qū)醫(yī)院內(nèi)分泌科;中南大學(xué)湘雅二醫(yī)院代謝內(nèi)分泌研究所;
【分類號】：R580
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本文編號：1803969