發(fā)布時(shí)間：2018-04-25 15:04

  本文選題：阿侖膦酸鈉 + 膦酸類��； 參考：《中國新藥與臨床雜志》2017年06期

【摘要】：目的研究低劑量阿侖膦酸鈉配合鼓勵教育是否能提高骨質(zhì)疏松癥患者服藥依從性。方法 210例已接受阿侖膦酸鈉常規(guī)劑量治療半年的骨質(zhì)疏松癥婦女隨機(jī)分為干預(yù)組與對照組,干預(yù)組(n=105)給予低劑量阿侖膦酸鈉(70 mg,2周1次)治療;對照組(n=105)為常規(guī)劑量(70 mg,每周1次)治療。兩組均依據(jù)入組前后骨轉(zhuǎn)換指標(biāo)變化,教育鼓勵患者堅(jiān)持服藥。觀察兩組治療6、12、18個(gè)月時(shí)的服藥順應(yīng)性、服藥持續(xù)性和不良反應(yīng)。運(yùn)用治療期間的藥物持有率(MPR)判斷患者服藥順應(yīng)性,MPR≥80%為服藥有順應(yīng)性;采用治療期間開始用藥至終止用藥的天數(shù)表達(dá)患者服藥持續(xù)性,停藥間隔超過30 d判斷為終止用藥。結(jié)果在第12個(gè)月和18個(gè)月隨訪期,干預(yù)組MPR中位數(shù)均高于對照組(P0.05)。在第6個(gè)月隨訪期干預(yù)組和對照組的有服藥順應(yīng)性的患者比例分別為89.5%和76.2%(P=0.010);在第12個(gè)月隨訪期分別為73.3%和58.1%(P=0.020);在第18個(gè)月隨訪期分別為67.6%和48.6%(P=0.005),兩組比較均有顯著差異。同樣,隨訪期第12個(gè)月和第18個(gè)月干預(yù)組持續(xù)服藥天數(shù)中位數(shù)也均高于對照組,分別為360(225,360)d和360(120,360)d(P=0.030),540(225,540)d和390(120,540)d(P=0.002)。結(jié)論低劑量阿侖膦酸鈉(70 mg,2周1次)口服配合鼓勵教育能提高骨質(zhì)疏松癥患者服藥依從性。
[Abstract]:Objective to study whether low-dose alendronate combined with encouraging education can improve the compliance of osteoporosis patients. Methods 210 osteoporosis women who had been treated with alendronate for half a year were randomly divided into two groups: intervention group (n = 105) and control group (n = 10 5). The control group (n = 105) was treated with a routine dose of 70 mg once a week. According to the changes of bone turnover index before and after entering the two groups, the patients were encouraged to take medicine. The drug compliance, drug persistence and adverse reactions were observed in the two groups at 12 and 18 months after treatment. According to the drug holding rate and MPRs during the treatment period, the patients' compliance was judged by MPR 鈮，

本文編號：1801830