本文選題：阿侖膦酸鈉 + 膦酸類��； 參考：《中國新藥與臨床雜志》2017年06期

【摘要】：目的研究低劑量阿侖膦酸鈉配合鼓勵教育是否能提高骨質疏松癥患者服藥依從性。方法 210例已接受阿侖膦酸鈉常規(guī)劑量治療半年的骨質疏松癥婦女隨機分為干預組與對照組,干預組(n=105)給予低劑量阿侖膦酸鈉(70 mg,2周1次)治療;對照組(n=105)為常規(guī)劑量(70 mg,每周1次)治療。兩組均依據(jù)入組前后骨轉換指標變化,教育鼓勵患者堅持服藥。觀察兩組治療6、12、18個月時的服藥順應性、服藥持續(xù)性和不良反應。運用治療期間的藥物持有率(MPR)判斷患者服藥順應性,MPR≥80%為服藥有順應性;采用治療期間開始用藥至終止用藥的天數(shù)表達患者服藥持續(xù)性,停藥間隔超過30 d判斷為終止用藥。結果在第12個月和18個月隨訪期,干預組MPR中位數(shù)均高于對照組(P0.05)。在第6個月隨訪期干預組和對照組的有服藥順應性的患者比例分別為89.5%和76.2%(P=0.010);在第12個月隨訪期分別為73.3%和58.1%(P=0.020);在第18個月隨訪期分別為67.6%和48.6%(P=0.005),兩組比較均有顯著差異。同樣,隨訪期第12個月和第18個月干預組持續(xù)服藥天數(shù)中位數(shù)也均高于對照組,分別為360(225,360)d和360(120,360)d(P=0.030),540(225,540)d和390(120,540)d(P=0.002)。結論低劑量阿侖膦酸鈉(70 mg,2周1次)口服配合鼓勵教育能提高骨質疏松癥患者服藥依從性。
[Abstract]:Objective to study whether low-dose alendronate combined with encouraging education can improve the compliance of osteoporosis patients. Methods 210 osteoporosis women who had been treated with alendronate for half a year were randomly divided into two groups: intervention group (n = 105) and control group (n = 10 5). The control group (n = 105) was treated with a routine dose of 70 mg once a week. According to the changes of bone turnover index before and after entering the two groups, the patients were encouraged to take medicine. The drug compliance, drug persistence and adverse reactions were observed in the two groups at 12 and 18 months after treatment. According to the drug holding rate and MPRs during the treatment period, the patients' compliance was judged by MPR 鈮，

本文編號：1801830