發(fā)布時(shí)間：2018-04-24 17:41

  本文選題：重癥肌無力 + 痿證　； 參考：《遼寧中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察復(fù)方黃杞湯劑聯(lián)合溴化吡啶斯的明治療I型、IIa型及IIb型重癥肌無力患者的臨床療效,為臨床提供切實(shí)可行的治療方法。材料與方法:將60例I型、IIa型及IIb型重癥肌無力患者按照隨機(jī)數(shù)字表隨機(jī)化分組的方式分為試驗(yàn)組(復(fù)方黃杞湯劑聯(lián)合溴化吡啶斯的明治療組)和對照組(溴化吡啶斯的明治療組),試驗(yàn)組30例:男患13例,女患17例,年齡10-75歲,平均年齡:48.8歲,病程1-97個(gè)月;對照組30例:男患14例,女患16例,年齡8-75歲,平均年齡:55,病程2-96個(gè)月。兩組均應(yīng)用溴化吡啶斯的明治療,試驗(yàn)組服用溴化吡啶斯的明同時(shí)加用復(fù)方黃杞湯劑治療,治療前及治療6個(gè)月后,兩組患者均采用重癥肌無力絕對評分表及中醫(yī)癥狀評分表評定,觀察比較兩組患者臨床癥狀的改善情況,數(shù)據(jù)應(yīng)用SPSS17.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)處理,計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差表示,對數(shù)據(jù)首先進(jìn)行正態(tài)分布檢驗(yàn),樣本符合正態(tài)分布者應(yīng)用t檢驗(yàn),不符合正態(tài)分布者應(yīng)用秩和檢驗(yàn),計(jì)數(shù)材料應(yīng)用R×C卡方檢驗(yàn),均以P0.05為有差異的標(biāo)準(zhǔn),具有統(tǒng)計(jì)學(xué)的意義。結(jié)果:1.將兩組患者性別、年齡、分型、病程、重癥肌無力臨床絕對評分及中醫(yī)癥狀評分等資料進(jìn)行統(tǒng)計(jì)分析后P值均大于0.05,表明兩組患者治療前具有可比性。2.經(jīng)過6個(gè)月的治療后,對兩組患者再次進(jìn)行重癥肌無力臨床絕對評分及中醫(yī)癥狀評分,經(jīng)過統(tǒng)計(jì)分析后,P值均小于0.05,說明兩組重癥肌無力臨床絕對評分及中醫(yī)癥狀評分具有可比性,存在統(tǒng)計(jì)學(xué)意義。3.試驗(yàn)組在緩解I型、IIa型及IIb型重癥肌無力患者的臨床療效方面優(yōu)于對照組,組間差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:復(fù)方黃杞湯劑聯(lián)合溴化吡啶斯的明可以明顯緩解I型、IIa型及IIb型重癥肌無力患者的臨床癥狀。
[Abstract]:Objective: to observe the clinical effect of compound Huangqi decoction combined with pyridamine bromide in the treatment of myasthenia gravis type I and IIb. Materials and methods: 60 patients with myasthenia gravis type I and IIb were randomly divided into two groups: the experimental group (treated with compound Huangqi decoction combined with pyridinium bromide) and the control group (brominated). Pyridamine treatment group (n = 30): 13 males, There were 17 female patients aged 10-75 years (mean age: 48.8 years, course of disease 1-97 months) and 30 cases in control group (14 males, 16 females, 8-75 years old, mean age: 55, 2-96 months). Both groups were treated with pyridamine bromide, while those in the experimental group were treated with compound Huangqi decoction before and after 6 months of treatment. The patients in both groups were assessed with the absolute score table of myasthenia gravis and the Chinese medicine symptom score table. The improvement of clinical symptoms was observed and compared between the two groups. The data were statistically processed by SPSS17.0 statistical software, and the measured data were expressed as mean 鹵standard deviation. The data were tested with normal distribution, the samples were tested with t test, those with normal distribution were tested by rank sum test, and the counting materials were tested by R 脳 C chi-square test, all of them were based on the standard of P0.05, which had statistical significance. The result is 1: 1. The data of sex, age, classification, course of disease, clinical absolute score of myasthenia gravis and TCM symptom score were analyzed statistically in the two groups (P > 0.05), which indicated that the two groups were comparable before treatment. After 6 months of treatment, the patients in both groups were given the absolute clinical score of myasthenia gravis and the TCM symptom score again. After statistical analysis, P values were less than 0.05, indicating that the two groups of myasthenia gravis clinical absolute score and TCM symptom score are comparable, there is statistical significance. 3. The treatment group was superior to the control group in relieving the clinical efficacy of type I and IIb type myasthenia gravis, and the difference between the two groups was statistically significant (P 0.05). Conclusion: compound Huangqi decoction combined with pyridamine bromide can significantly relieve the clinical symptoms of patients with myasthenia gravis of type I and type II and IIb.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R746.1

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