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三甲基氯化錫中毒研究進展

發(fā)布時間:2018-04-19 14:12

  本文選題:三甲基氯化錫 + 聚氯乙烯 ; 參考:《中國職業(yè)醫(yī)學》2017年01期


【摘要】:正有機錫熱穩(wěn)定劑廣泛存在于聚氯乙烯(Polyvinyl chloride,PVC)塑料制品,其合成過程可產(chǎn)生一種劇毒副產(chǎn)物~[1]——三甲基氯化錫(Trimethyltin chloride,TMT)。它無色有腐草氣味,遇熱易揮發(fā),具有脂水兩溶性,能通過呼吸道、消化道以及皮膚等通道產(chǎn)生中毒反應~[2]。患者中毒后會產(chǎn)生激動、癲癇、腹瀉及低血鉀癥等多種臨床表現(xiàn),重癥者可出現(xiàn)昏迷甚至死亡~[3]。PVC塑料應用廣泛,因此TMT中毒不僅是職業(yè)
[Abstract]:N-organotin thermal stabilizers are widely used in polyvinyl chloride PVC) plastics. A highly toxic by-product ~ [1] -trimethyltin chloride trimethyltin chloriden (TMTT) can be produced during the synthesis process.It has colorless smell of saprophyte, volatile in heat, lipids and water soluble, and can produce toxic reaction through respiratory tract, digestive tract and skin.There are many clinical manifestations such as agitation, epilepsy, diarrhea and hypokalemia after poisoning. Severe patients can appear in coma or even death. PVC plastics are widely used, so TMT poisoning is not only an occupation.
【作者單位】: 廣州醫(yī)科大學生理教研室;
【基金】:國家自然科學基金(81200038) 廣東省產(chǎn)業(yè)技術(shù)研究與開發(fā)專項資金計劃項目(2013B021800094)
【分類號】:R135.1
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本文編號:1773416

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