本文選題：型糖尿病 + 骨質(zhì)疏松��； 參考：《中國骨質(zhì)疏松雜志》2017年01期

【摘要】：目的探討男性2型糖尿病(type 2 diabetes mellitus,T2DM)患者骨密度(bone mineral density,BMD)的變化與C肽水平關(guān)系。方法采用雙能X線骨密度儀對(duì)143例糖尿病患者和63例非糖尿病者(對(duì)照組)進(jìn)行腰椎L1-4骨密度測(cè)量,記錄年齡、體重指數(shù)(body mass index,BMI)、糖尿病病程。檢測(cè)糖化血紅蛋白(Hb A1c)、骨代謝指標(biāo)及空腹、餐后2h血糖、C肽。采用C肽改良HOMA公式計(jì)算胰島β細(xì)胞功能指數(shù)(HOMA-β)和胰島素抵抗指數(shù)(HOMA-CR)。糖尿病患者根據(jù)BMD水平分為2組:骨量正常組(DM-A組)和骨量減少/骨質(zhì)疏松組(DM-B組)。結(jié)果糖尿病患者骨密度、空腹及餐后2h C肽均低于對(duì)照組(P0.05)。與DM-A組相比,DM-B組HOMA-CR、I型膠原羧基末端肽β特殊序列(βCTX)水平升高(P0.05),I型前膠原羧基末端肽(PICP)水平降低(P0.05)。多元逐步回歸結(jié)果提示,BMI和空腹C肽是腰椎骨密度的主要影響因素。結(jié)論男性2型糖尿病患者骨密度與空腹C肽水平密切相關(guān),C肽水平偏低的男性2型糖尿病患者更容易發(fā)生骨密度降低。
[Abstract]:Objective to investigate the relationship between bone mineral density (BMD) and C-peptide level in male patients with type 2 diabetes mellitus (type 2 diabetes mellitusus T2DM).Methods L1-4 bone mineral density of lumbar vertebrae was measured by dual energy X-ray absorptiometry in 143 diabetic patients and 63 non-diabetic subjects (control group). Age, body mass index (BMI) and body mass index (mass) were recorded.The levels of HbA1cX, bone metabolism, fasting and 2 h postprandial blood glucose C peptide were measured.The 尾 cell function index (HOMA- 尾) and insulin resistance index (HOMA-CRA) were calculated by modified C-peptide HOMA formula.Diabetic patients were divided into two groups according to BMD level: normal bone mass group (DM-A group) and osteopenia / osteoporosis group (DM-B group).Results BMD, fasting and 2 h postprandial C peptide were lower in diabetic patients than those in control group (P 0.05).Compared with DM-A group, HOMA-CRN I carboxyl terminal peptide 尾 (尾 CTX) level in DM-B group was increased and the level of P0.05 procollagen carboxyl terminal peptide (PICPX) was decreased in DM-B group.Multiple stepwise regression analysis showed that BMI and fasting C-peptide were the main influencing factors of lumbar bone mineral density.Conclusion the BMD of male type 2 diabetic patients is closely related to the fasting C-peptide level. The male type 2 diabetic patients with low C-peptide level are more likely to develop BMD decrease.
【作者單位】： 上海市楊浦區(qū)市東醫(yī)院內(nèi)分泌科;同濟(jì)大學(xué)附屬同濟(jì)醫(yī)院內(nèi)分泌科;
【基金】：上海市楊浦區(qū)衛(wèi)生和計(jì)劃生育委員會(huì)青年科研課題(201306)
【分類號(hào)】：R587.1

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本文編號(hào)：1773136