本文選題：丙硫氧嘧啶 + ANCA相關(guān)性血管炎��； 參考：《中國(guó)新藥雜志》2017年05期

【摘要】：目的:探討臨床藥師在丙硫氧嘧啶(propylthiouracil,PTU)誘發(fā)的抗中性粒細(xì)胞胞漿抗體相關(guān)性血管炎[anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitis,AAV]多學(xué)科診療中的作用。方法:對(duì)某院收治的臨床藥師參與診療的2例PTU引起的AAV病例進(jìn)行回顧性分析,總結(jié)PTU的致病規(guī)律及臨床特點(diǎn),探索臨床診斷和藥學(xué)關(guān)聯(lián)性診斷關(guān)系,總結(jié)個(gè)體化藥物治療方案及藥學(xué)監(jiān)護(hù)重點(diǎn)。結(jié)果:PTU誘發(fā)的AAV潛伏期長(zhǎng),臨床異質(zhì)性大,可表現(xiàn)為皮膚、關(guān)節(jié)、肺、腎臟、消化道、骨髓損害,常有特征性免疫抗體異常,其臨床診斷和藥學(xué)關(guān)聯(lián)性診斷相互補(bǔ)充,通過(guò)停藥及使用糖皮質(zhì)激素、環(huán)磷酰胺抗免疫治療得到有效緩解。藥師全程參與診療,有利于患者早期診斷和個(gè)體化治療。結(jié)論:PTU誘發(fā)的AAV,早期不易臨床診斷和識(shí)別誘發(fā)藥物,臨床表現(xiàn)及治療個(gè)體差異大。臨床藥師早期、全程參與藥源性疾病診療,能發(fā)揮不可替代的作用。
[Abstract]:Objective: to investigate the role of clinical pharmacists in the multidisciplinary diagnosis and treatment of anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitis associated with propylthiouraciline (PTU) induced by propylthiouraciline (PTU).Methods: two cases of AAV caused by PTU were analyzed retrospectively. The pathogenicity and clinical characteristics of PTU were summarized, and the relationship between clinical diagnosis and pharmacological diagnosis was explored.To summarize the individualized drug therapy and the key points of pharmaceutical monitoring.Results AAV induced by 1: PTU had long latent period and large clinical heterogeneity. It could be characterized by skin, joint, lung, kidney, digestive tract and bone marrow damage.Cyclophosphamide anti-immunotherapy is effective by stopping medication and using glucocorticoid.Pharmacists participate in the whole diagnosis and treatment, which is beneficial to the early diagnosis and individualized treatment of patients.Conclusion it is difficult to diagnose and identify the evoked drugs in the early stage of AAVS induced by: 1% PTU, and there are great differences in clinical manifestations and treatment individuals.Early clinical pharmacists participate in the diagnosis and treatment of drug-induced diseases, can play an irreplaceable role.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院藥學(xué)部;重慶醫(yī)科大學(xué)附屬第一醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R593.2

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本文編號(hào)：1758374