本文選題：鮭魚降鈣素注射液 + 唑來膦酸鈉注射液�。� 參考：《南昌大學(xué)》2017年碩士論文

【摘要】：目的:研究鮭魚降鈣素注射液與唑來膦酸注射液在治療絕經(jīng)后骨質(zhì)疏松癥的臨床療效對比,為絕經(jīng)后骨質(zhì)疏松癥的治療提供依據(jù)。方法:資料選自2015年2月—2016年10月期間在南昌大學(xué)第三附屬醫(yī)院住院治療的絕經(jīng)后骨質(zhì)疏松癥患者62例,其中鮭魚降鈣素注射液組30例,唑來膦酸注射液組32例,同時口服骨化三醇、鈣制劑(碳酸鈣)為基礎(chǔ)治療,治療時間為6個月。62例患者治療前后均行骨密度(bone mineral density,BMD)檢查、同時檢測患者腎功能、血鈣(blood calcium,BC)、血磷(Blood phosphorus P)、骨堿性膦酸酶(Bone alkaline phosphatase,BALP)、評估疼痛改善情況,判定療效。結(jié)果:1、兩組患者治療前后腎功能、血鈣、血磷、骨堿性膦酸酶水平均無明顯差異,P0.05,比較無統(tǒng)計學(xué)意義。2、兩組治療后VAS評分較治療前低,但唑來膦酸注射液組VAS評分較鮭魚降鈣素注射液組顯著降低,P0.05,比較有統(tǒng)計學(xué)意義。3、兩組患者治療后骨密度值較治療前均升高,唑來膦酸注射液組患者腰椎、股骨頸T值與鮭魚降鈣素注射液組比較差異顯著,P0.05,比較有統(tǒng)計學(xué)意義。4、在本研究中唑來膦酸注射液組不良反應(yīng)發(fā)生率低。結(jié)論:唑來膦酸注射液與鮭魚降鈣素注射液均可以有效提高絕經(jīng)后骨質(zhì)疏松癥患者的骨密度,減輕骨痛癥狀,但唑來磷酸注射液組療效優(yōu)于鮭魚降鈣素注射液組。
[Abstract]:Objective: to compare the clinical efficacy of salmon calcitonin injection and zoledronic acid injection in the treatment of postmenopausal osteoporosis and to provide evidence for the treatment of postmenopausal osteoporosis.Methods: Sixty-two postmenopausal osteoporosis patients, 30 in salmon calcitonin injection group and 32 in zoledronic acid injection group, were hospitalized in the third affiliated Hospital of Nanchang University from February 2015 to October 2016.At the same time, the patients were treated with oral ossification triol and calcium carbonate (calcium carbonate) for 6 months. 62 patients were examined with bone mineral density before and after treatment. The renal function of the patients was also measured at the same time.Blood calcium, phosphorus, phosphorus and bone alkaline phosphatase were used to evaluate the pain improvement and evaluate the curative effect.Results there was no significant difference in renal function, serum calcium, blood phosphorus and bone alkaline phosphatase levels between the two groups before and after treatment (P 0.05). There was no significant difference between the two groups (P 0.05). The VAS score of the two groups was lower than that before treatment.However, the VAS score of zoledronic acid injection group was significantly lower than that of salmon calcitonin injection group (P 0.05, P < 0.05). The bone mineral density (BMD) in both groups was higher than that before treatment, and the lumbar vertebrae of zoledronic acid injection group was significantly lower than that of salmon calcitonin injection group.T value of femoral neck was significantly different from that of salmon calcitonin injection group (P0.05, P < 0.05). In this study, the incidence of adverse reactions in Zoledronic acid injection group was lower than that in salmon calcitonin injection group (P 0.05).Conclusion: both zoledronic acid injection and salmon calcitonin injection can effectively increase the bone density and relieve the symptoms of bone pain in postmenopausal osteoporosis patients, but the efficacy of zoledronic acid injection group is better than that of salmon calcitonin injection group.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R580

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