本文選題：骨質疏松 + 運動訓練��； 參考：《中國老年學雜志》2017年11期

【摘要】：目的探討跑臺運動、游泳等不同運動訓練方式對老年性骨質疏松小鼠骨生物力學的影響。方法取小鼠66只,根據(jù)不同運動訓練方式將小鼠分為游泳組、跑臺組及對照組,每組22只。采用切除雙側卵巢方法建立老年性骨質疏松模型。游泳組前3 d每次訓練30 min,后4 d每次訓練40 min,水深40 cm。跑臺組持續(xù)性水平運動,前3 d每次30 min,跑臺速度0.8 m/s;后4 d跑40 min,跑臺速度1.0 m/s,共訓練4 w。對照組不進行運動干預自然恢復。采用骨密度儀及電子萬能試驗機測定小鼠骨密度(BMD)及右側股骨、腰椎骨生物力學指標。結果跑臺組、游泳組及對照組在1 w、2 w體重差異無統(tǒng)計學意義(P0.05);跑臺組小鼠在3 w、4 w體重顯著高于游泳組與對照組(P0.05)。(2)跑臺組小鼠鈣、磷水平顯著低于游泳組和對照組(P0.05),堿性磷酸酶(AKP)、抗酒石酸酸性磷酸酶(STR-ACP)水平顯著高于游泳組(P0.05);游泳組鈣、AKP、STR-ACP水平顯著低于對照組(P0.05),磷顯著高于對照組(P0.05)。(3)跑臺組右側股骨與腰椎骨BMD水平顯著高于游泳組與對照組(P0.05),游泳組右側股骨與腰椎骨BMD水平顯著高于對照組(P0.05)。(4)跑臺組小鼠骨生物力學指標顯著高于游泳組與對照組(P0.05)。游泳組小鼠骨生物力學指標顯著高于對照組(P0.05)。結論運動訓練對老年性骨質疏松小鼠生物力學性能有一定的改善,游泳、跑臺運動對骨質疏松小鼠有預防和緩解作用,可以維持并提高小鼠BMD,且生物力學顯示跑臺運動訓練更加適宜。
[Abstract]:Objective to investigate the effects of different exercise training methods such as treadmill and swimming on bone biomechanics in senile osteoporosis mice.Methods 66 mice were divided into swimming group, running platform group and control group according to different training methods.The model of senile osteoporosis was established by bilateral ovariectomy.The swimming group was trained for 30 minutes on the first 3 days and 40 minutes on the last 4 days with a water depth of 40 cm.In the treadmill group, the running speed was 0.8 m / s for 30 minutes on the first 3 days and 1.0 m / s for the last 4 days.The control group did not carry on the exercise intervention natural recovery.Bone mineral density (BMD) and the biomechanical indexes of right femur and lumbar vertebrae were measured by BMD and electronic universal testing machine.Results there was no significant difference in body weight between the treadmill group, the swimming group and the control group at the 1st week and 2nd week, but the body weight of the mice in the treadmill group was significantly higher than that in the swimming group and the control group at 4 weeks.The levels of phosphorus, alkaline phosphatase and tartrate-resistant acid phosphatase (STR-ACPP) in swimming group were significantly lower than those in swimming group and control group (P 0.05, P 0.05), and the levels of calcium AKPnst STR-ACP in swimming group were significantly lower than those in control group (P 0.05, P 0.05, P 0.05, P 0.05, P 0.05, P 0.05, P < 0.05, P 0.05, P 0.05, P < 0.05, P < 0.05, P 0.05, P 0.05, P 0.05, P 0.05, respectively).The BMD level of femur and lumbar vertebrae was significantly higher than that of swimming group and control group (P 0.05). The BMD level of right femur and lumbar vertebrae in swimming group was significantly higher than that in control group (P 0.05. 05) the bone biomechanical index of mice in platform running group was significantly higher than that in swimming group and control group (P 0.05).The biomechanical index of bone in swimming group was significantly higher than that in control group (P 0.05).Conclusion exercise training can improve the biomechanical properties of senile osteoporosis mice. Swimming and treadmill exercise can prevent and relieve osteoporosis mice.BMD could be maintained and increased in mice, and biomechanics showed that platform training was more suitable.
【作者單位】： 中國藥科大學體育部;
【基金】：江蘇省自然科學基金面上項目(BK20151218);江蘇省自然科學基金青年基金(BK20150860)
【分類號】：R-332;R580

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