本文選題：骨質(zhì)疏松 + 運(yùn)動(dòng)訓(xùn)練��； 參考：《中國(guó)老年學(xué)雜志》2017年11期

【摘要】：目的探討跑臺(tái)運(yùn)動(dòng)、游泳等不同運(yùn)動(dòng)訓(xùn)練方式對(duì)老年性骨質(zhì)疏松小鼠骨生物力學(xué)的影響。方法取小鼠66只,根據(jù)不同運(yùn)動(dòng)訓(xùn)練方式將小鼠分為游泳組、跑臺(tái)組及對(duì)照組,每組22只。采用切除雙側(cè)卵巢方法建立老年性骨質(zhì)疏松模型。游泳組前3 d每次訓(xùn)練30 min,后4 d每次訓(xùn)練40 min,水深40 cm。跑臺(tái)組持續(xù)性水平運(yùn)動(dòng),前3 d每次30 min,跑臺(tái)速度0.8 m/s;后4 d跑40 min,跑臺(tái)速度1.0 m/s,共訓(xùn)練4 w。對(duì)照組不進(jìn)行運(yùn)動(dòng)干預(yù)自然恢復(fù)。采用骨密度儀及電子萬(wàn)能試驗(yàn)機(jī)測(cè)定小鼠骨密度(BMD)及右側(cè)股骨、腰椎骨生物力學(xué)指標(biāo)。結(jié)果跑臺(tái)組、游泳組及對(duì)照組在1 w、2 w體重差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);跑臺(tái)組小鼠在3 w、4 w體重顯著高于游泳組與對(duì)照組(P0.05)。(2)跑臺(tái)組小鼠鈣、磷水平顯著低于游泳組和對(duì)照組(P0.05),堿性磷酸酶(AKP)、抗酒石酸酸性磷酸酶(STR-ACP)水平顯著高于游泳組(P0.05);游泳組鈣、AKP、STR-ACP水平顯著低于對(duì)照組(P0.05),磷顯著高于對(duì)照組(P0.05)。(3)跑臺(tái)組右側(cè)股骨與腰椎骨BMD水平顯著高于游泳組與對(duì)照組(P0.05),游泳組右側(cè)股骨與腰椎骨BMD水平顯著高于對(duì)照組(P0.05)。(4)跑臺(tái)組小鼠骨生物力學(xué)指標(biāo)顯著高于游泳組與對(duì)照組(P0.05)。游泳組小鼠骨生物力學(xué)指標(biāo)顯著高于對(duì)照組(P0.05)。結(jié)論運(yùn)動(dòng)訓(xùn)練對(duì)老年性骨質(zhì)疏松小鼠生物力學(xué)性能有一定的改善,游泳、跑臺(tái)運(yùn)動(dòng)對(duì)骨質(zhì)疏松小鼠有預(yù)防和緩解作用,可以維持并提高小鼠BMD,且生物力學(xué)顯示跑臺(tái)運(yùn)動(dòng)訓(xùn)練更加適宜。
[Abstract]:Objective to investigate the effects of different exercise training methods such as treadmill and swimming on bone biomechanics in senile osteoporosis mice.Methods 66 mice were divided into swimming group, running platform group and control group according to different training methods.The model of senile osteoporosis was established by bilateral ovariectomy.The swimming group was trained for 30 minutes on the first 3 days and 40 minutes on the last 4 days with a water depth of 40 cm.In the treadmill group, the running speed was 0.8 m / s for 30 minutes on the first 3 days and 1.0 m / s for the last 4 days.The control group did not carry on the exercise intervention natural recovery.Bone mineral density (BMD) and the biomechanical indexes of right femur and lumbar vertebrae were measured by BMD and electronic universal testing machine.Results there was no significant difference in body weight between the treadmill group, the swimming group and the control group at the 1st week and 2nd week, but the body weight of the mice in the treadmill group was significantly higher than that in the swimming group and the control group at 4 weeks.The levels of phosphorus, alkaline phosphatase and tartrate-resistant acid phosphatase (STR-ACPP) in swimming group were significantly lower than those in swimming group and control group (P 0.05, P 0.05), and the levels of calcium AKPnst STR-ACP in swimming group were significantly lower than those in control group (P 0.05, P 0.05, P 0.05, P 0.05, P 0.05, P 0.05, P < 0.05, P 0.05, P 0.05, P < 0.05, P < 0.05, P 0.05, P 0.05, P 0.05, P 0.05, respectively).The BMD level of femur and lumbar vertebrae was significantly higher than that of swimming group and control group (P 0.05). The BMD level of right femur and lumbar vertebrae in swimming group was significantly higher than that in control group (P 0.05. 05) the bone biomechanical index of mice in platform running group was significantly higher than that in swimming group and control group (P 0.05).The biomechanical index of bone in swimming group was significantly higher than that in control group (P 0.05).Conclusion exercise training can improve the biomechanical properties of senile osteoporosis mice. Swimming and treadmill exercise can prevent and relieve osteoporosis mice.BMD could be maintained and increased in mice, and biomechanics showed that platform training was more suitable.
【作者單位】： 中國(guó)藥科大學(xué)體育部;
【基金】：江蘇省自然科學(xué)基金面上項(xiàng)目(BK20151218);江蘇省自然科學(xué)基金青年基金(BK20150860)
【分類(lèi)號(hào)】：R-332;R580

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