本文選題：生物鐘基因 + 糖尿病　； 參考：《山東醫(yī)藥》2017年39期

【摘要】：生物鐘基因包括外周生物鐘基因和中樞生物鐘基因。目前發(fā)現(xiàn)的生物鐘基因主要有芳香烴受體核轉位蛋白樣1基因(BMAL1)、時鐘基因(CLOCK)、隱色素基因1(Cry1)、隱色素基因2(Cry2)、周期基因1(Per1)、周期基因2(Per2)、周期基因3(Per3)等。研究表明外周生物鐘基因和中樞生物鐘基因表達改變均與糖尿病(DM)的發(fā)病有關,如肌肉、外周血中的BMAL1基因,肝臟、胰腺中的CLOCK、BMAL1基因,下丘腦視交叉上核中的CLOCK、BMAL1、Per、Cry基因等。這些生物鐘基因表達異常可引起葡萄糖代謝紊亂、葡萄糖耐受性降低、胰島素分泌障礙、胰島素抵抗,最終導致DM的發(fā)病。
[Abstract]:The clock gene includes the peripheral clock gene and the central clock gene.At present, the biological clock genes are mainly aromatics receptor nuclear translocation protein-like gene (BMAL1), clock gene (CLOCK1), cryptochrome gene 1 (Cry1), cryptochrome gene 2 (Cry2), cycle gene (1), cycle gene (2), cycle gene (2), cycle gene (3), and so on.It has been found that the changes of the expression of peripheral and central clock genes are related to the pathogenesis of DM, such as the BMAL1 gene in muscle, peripheral blood, the BMAL1 gene in liver and pancreas, and the CLOCK-BMAL1 / Per-Cry gene in supraoptic nucleus of hypothalamus.The abnormal expression of these circadian clock genes may cause glucose metabolism disorder, glucose tolerance decrease, insulin secretion disturbance, insulin resistance, and eventually lead to the pathogenesis of DM.
【作者單位】： 遵義醫(yī)學院病理生理學教研室;
【基金】：國家自然科學基金資助項目(81260131) 貴州省自然科學基金項目(黔科合J字2011-2124)
【分類號】：R587.1
，

本文編號：1749152