本文選題：疏肝健脾消癭湯 + 橋本氏甲狀腺炎��； 參考：《山東中醫(yī)藥大學》2016年碩士論文

【摘要】：目的:觀察疏肝健脾消癭湯合優(yōu)甲樂治療肝郁脾虛型橋本氏甲狀腺炎合并甲減的臨床療效,并結合現(xiàn)代醫(yī)學深入探索中藥的作用機制,從而突出中醫(yī)藥的優(yōu)勢。方法:將臨床上診斷為橋本氏甲狀腺炎合并甲減肝郁脾虛型的60例患者隨機分為兩組:治療組(B組)、對照組(A組),B組30例,給予疏肝健脾消癭湯合優(yōu)甲樂治療;A組30例,給予優(yōu)甲樂治療,4周為一療程,連用12周。所有患者治療前、后測定:(1)甲狀腺激素水平及TPOAb、TGAb水平;(2)甲狀腺左右葉及峽部厚度;(3)CD4(10)、CD8(10)、CD4(10)/CD8(10)水平;(4)中醫(yī)證候積分及綜合療效評定;(5)血常規(guī)、肝功、腎功等安全性指標。結果:兩組治療前比較,年齡、性別、病程、甲狀腺激素水平、TPOAb、TGAb滴度水平、甲狀腺左右葉及峽部厚度、CD4(10)、CD8(10)、CD4(10)/CD8(10)水平及中醫(yī)證候積分等方面無明顯差異,P(29)0.05,具有可比性;治療后比較:兩組綜合療效比較,B組總有效率96.7%;A組總有效率83.3%,B組總有效率明顯高于A組,P0.05;兩組癥狀積分均較治療前有所降低,B組療效優(yōu)于A組,P0.05;B組在改善甲狀腺激素(FT4、TSH)水平,TPOAb、TGAb滴度水平,甲狀腺左右葉及峽部厚度,CD4(10)、CD4(10)/CD8(10)水平方面明顯優(yōu)于A組,P0.05;安全性指標較治療前均未見明顯變化。結論:疏肝健脾消癭湯合優(yōu)甲樂治療橋本氏甲狀腺炎合并甲減療效肯定,值得進一步深入探討。
[Abstract]:Objective: to observe the clinical effect of Shugan Jianpi Xiaoying decoction and Youjia Le in treating Hashimoto's thyroiditis combined with hypothyroidism in the type of liver stagnation and spleen deficiency, and to explore the mechanism of traditional Chinese medicine in order to highlight the advantages of traditional Chinese medicine.Methods: sixty patients with Hashimoto's thyroiditis combined with hypothyroidism liver depression and spleen deficiency were randomly divided into two groups: treatment group B group, control group A group (n = 30) and group A (n = 30) treated with Shugan Jianpi Xiaoying decoction and you Jia Le group (n = 30).A course of treatment was given for 4 weeks and continued for 12 weeks.Before and after treatment, the levels of thyroid hormone and TPOAbTGAb were measured before and after treatment. (2) the thickness of the left and right lobes and isthmus of the thyroid gland was determined.Results: there was no significant difference between the two groups in age, sex, course of disease, thyroid hormone level and TPOAb TGAb titer, the thickness of left and right thyroid lobe and isthmus and the level of CD410 / CD810 / CD810 and the score of TCM syndromes (P290.05).Comparison after treatment: the total effective rate of group B was 96. 7% and the total effective rate of group B was significantly higher than that of group A (83.33%), and the total effective rate of group B was significantly higher than that of group A (P 0. 05%), and the symptom score of group B was lower than that of group B (P 0. 05%) before treatment, and the total effective rate of group B was better than that of group B (group B) in improving thyroid gland.The titer of TPOAbAb TGAb,The thickness of left and right lobe and isthmus of thyroid gland was significantly better than that of group A (P 0.05), and there was no significant change in safety index.Conclusion: the curative effect of Shugan Jianpi Xiaoying decoction combined with Youjia Le in treating Hashimoto's thyroiditis with hypothyroidism is definite and worthy of further discussion.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R581

【參考文獻】

相關期刊論文 前10條

1 楊旭超;西力扎提·阿不來提;木合布力·阿布力孜;任丙昭;;3-甲氧基異甘草素的合成及其對宮頸癌細胞的影響[J];新疆醫(yī)科大學學報;2016年02期

2 李季泓;;黃芪注射液對慢性心力衰竭患者外周血清BNP水平與心衰程度的相關性研究[J];遼寧中醫(yī)藥大學學報;2016年02期

3 張慧;裴志東;陳瑩;康廷國;;18α,18β-甘草酸對小鼠急性肝損傷的保護作用及其聯(lián)合用藥配伍比例探討[J];中國實驗方劑學雜志;2016年02期

4 章培軍;郭敏芳;邢雁霞;楊德兵;張麗紅;李艷花;薛慧清;肖保國;馬存根;;黃芪糖蛋白對實驗性自身免疫性腦脊髓炎小鼠的免疫調節(jié)作用[J];細胞與分子免疫學雜志;2016年01期

5 湯景霞;;黃芪提取物對IEC-6細胞遷移的影響[J];中國處方藥;2016年01期

6 王小龍;高城翰;高天舒;;辨體辨證治療甲狀腺功能正常橋本甲狀腺炎[J];環(huán)球中醫(yī)藥;2015年11期

7 谷鑫;吳承玉;;從“肝脾病位、痰瘀病性”論治橋本甲狀腺炎[J];中國中醫(yī)基礎醫(yī)學雜志;2015年05期

8 王秋虹;魏軍平;王師菡;;林蘭教授中西醫(yī)結合治療橋本甲狀腺炎經(jīng)驗擷菁[J];環(huán)球中醫(yī)藥;2015年03期

9 黃遵宇;;補腎健脾疏肝方治療橋本氏甲狀腺炎臨床研究[J];四川中醫(yī);2014年11期

10 周紹榮;薛慈民;;“消癭扶正方”治療橋本甲狀腺炎30例臨床觀察[J];江蘇中醫(yī)藥;2013年09期

，

本文編號：1748101