本文選題：糖尿病視網(wǎng)膜病變 + 血脂　； 參考：《中國糖尿病雜志》2017年08期

【摘要】：目的觀察不同時期DR患者血清脂蛋白相關(guān)磷脂A2(Lp-PLA2)水平,并進行相關(guān)因素分析。方法 160例T2DM患者經(jīng)眼底照相結(jié)果分為無糖尿病視網(wǎng)膜病變(NDR)組、非增殖期糖尿病視網(wǎng)膜病變(NPDR)組、增殖期糖尿病視網(wǎng)膜病變(PDR)組。分別測定FPG、TG、血清Lp-PLA2、血管內(nèi)皮生長因子(VEGF)水平;對影響血清Lp-PLA2水平的因素進行多重線性回歸分析。結(jié)果PDR和NPDR組血清Lp-PLA2[(180.90±48.71)vs(153.70±40.61)vs(127.01±37.64)μg/L]、VEGF[(170.34±35.47)vs(146.16±36.01)vs(85.63±24.20)pg/ml]水平與NDR比較,差異均有統(tǒng)計學(xué)意義(P0.01)。PDR組血清Lp-PLA2[(180.90±48.71)vs(153.70±40.61)μg/L]、VEGF[(170.34±35.47)vs(146.16±36.01)pg/ml]水平與NPDR組比較,差異有統(tǒng)計學(xué)意義(P0.01)。糖尿病病程(β=0.135,P0.05)、HbA1c(β=0.141,P0.01)、LDL-C(β=0.291,P0.05)、TG(β=0.347,P0.05)、VEGF水平(β=0.313,P0.05)和DR程度(β=0.354,P0.05)均與Lp-PLA2水平相關(guān)。結(jié)論 DR患者血清Lp-PLA2水平升高,與病程、血糖、TG、VEGF水平和DR程度密切相關(guān)。
[Abstract]:Objective to observe the level of lipoprotein associated phospholipid A _ 2 (Lp-PLA _ 2) in patients with Dr at different stages and to analyze the related factors.Methods one hundred and sixty patients with T2DM were divided into three groups: non proliferative diabetic retinopathy group, non proliferative diabetic retinopathy group and proliferative diabetic retinopathy group.The levels of Lp-PLA2, Lp-PLA2 and VEGF were measured, and the factors affecting serum Lp-PLA2 were analyzed by multiple linear regression analysis.緇撴灉PDR鍜孨PDR緇勮娓匧p-PLA2[(180.90鹵48.71)vs(153.70鹵40.61)vs(127.01鹵37.64)渭g/L],VEGF[(170.34鹵35.47)vs(146.16鹵36.01)vs(85.63鹵24.20)pg/ml]姘村鉤涓嶯DR姣旇緝,宸紓鍧囨湁緇熻瀛︽剰涔，

本文編號：1747363