本文選題：精神分裂癥　切入點(diǎn)：代謝綜合征　出處：《實(shí)用醫(yī)學(xué)雜志》2017年19期

【摘要】：目的探討精神分裂癥伴代謝綜合征患者心臟自主神經(jīng)功能狀況,并分析其影響因素,以減少患者心源性猝死的發(fā)生。方法 168例符合ICD-10精神分裂癥診斷標(biāo)準(zhǔn)的患者分為78例精神分裂癥伴有代謝綜合征組(A組)和90例精神分裂癥不伴有代謝綜合征組(B組),對(duì)其分別進(jìn)行24 h動(dòng)態(tài)心電圖檢查,分析其心率變異性(HRV),并與92例正常對(duì)照組(C組)進(jìn)行對(duì)比。結(jié)果 A組和B組LF、HF、SDNN、SDANN、RMSSD、PNN50值均明顯低于C組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),且B組LF、HF、SDNN、SDANN、RMSSD、PNN50值明顯高于A組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。排除精神分裂癥自身的影響,Logistic回歸分析顯示HRV值的影響因素為病程(OR=1.864,95%CI 1.110~3.128)、年齡(OR=1.170,95%CI 1.018~2.491)、抗精神病藥物種類(lèi)(OR=2.419,95%CI 0.976~1.835)、腹部肥胖(OR=2.425,95%CI1.347~4.366)、血壓值(OR=1.263,95%CI 1.575~3.937)、血糖值(OR=3.376,95%CI 1.359~2.923)、血脂值(OR=2.178,95%CI 1.492~6.756)。結(jié)論精神分裂癥伴代謝綜合征患者存在明顯心臟自主神經(jīng)功能異常,排除精神分裂癥自身的影響,其他可能的危險(xiǎn)因素是病程、年齡、抗精神病藥物種類(lèi)、腹部肥胖、血壓值、血糖值、血脂值。
[Abstract]:Objective to investigate the cardiac autonomic nervous function in schizophrenic patients with metabolic syndrome and analyze its influencing factors in order to reduce the incidence of sudden cardiac death.Methods ICD-10 schizophrenic patients were divided into two groups: 78 patients with schizophrenia with metabolic syndrome (group A) and 90 patients with schizophrenia without metabolic syndrome (group B). The patients were examined by dynamic electrocardiogram for 24 hours.Heart rate variability (HRV) was analyzed and compared with 92 normal controls (group C).Results the values of SDNN50 in group A and group B were significantly lower than those in group C (P 0.05), and the values of SMSSDNN in group B were significantly higher than those in group A (P 0.05).鎺掗櫎綺劇鍒嗚鐥囪嚜韜殑褰卞搷,Logistic鍥炲綊鍒嗘瀽鏄劇ずHRV鍊肩殑褰卞搷鍥犵礌涓虹梾紼，

本文編號(hào)：1704889