本文選題：橋本氏甲狀腺炎　切入點(diǎn)：甲狀腺乳頭狀癌　出處：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:橋本氏甲狀腺炎合并甲狀腺乳頭狀癌的現(xiàn)象越來越多的被人們發(fā)現(xiàn),為了探究橋本氏甲狀腺炎合并甲狀腺乳頭狀癌的臨床特點(diǎn),將其與單純甲狀腺乳頭狀癌進(jìn)行比較和分析,從而加深對(duì)該疾病的認(rèn)知,并為更好的診斷、治療及預(yù)后評(píng)估提供依據(jù)。方法:回顧性分析山西醫(yī)科大學(xué)附屬山西省腫瘤醫(yī)院2015年11月到2016年11月經(jīng)頭頸外科手術(shù)治療且病理證實(shí)為橋本氏甲狀腺炎合并甲狀腺乳頭狀癌57例,分為A組,單純甲狀腺乳頭狀癌116例,分為B組。對(duì)比兩組病例在性別、年齡、腫瘤大小、術(shù)前TSH水平、微小癌發(fā)生率、中央組淋巴結(jié)轉(zhuǎn)移率、TNM分期方面的特點(diǎn)。結(jié)果:1、A組中女性患者50例,占該組87.7%,B組中的女性患者為76例,占該組65.5%,P0.000,差異有統(tǒng)計(jì)學(xué)意義。2、A組患者年齡為42.3±13.6歲,B組患者年齡為45.7±14.5歲,P=0.142,差異無統(tǒng)計(jì)學(xué)意義。3、A組患者腫瘤大小為1.46±0.87cm,B組患者腫瘤大小為2.02±1.21cm,P0.000,差異有統(tǒng)計(jì)學(xué)意義。4、A組患者術(shù)前TSH水平為2.34±2.12m IU/L,B組患者為1.73±1.56 m IU/L,P=0.028,差異有統(tǒng)計(jì)學(xué)意義。5、A組患者微小癌發(fā)生率為42.1%,B組為37.1%,P=0.523,差異無統(tǒng)計(jì)學(xué)意義。6、A組患者中央組淋巴結(jié)轉(zhuǎn)移率為24.6%,B組患者淋巴結(jié)轉(zhuǎn)移率為45.7%,P=0.007,差異有統(tǒng)計(jì)學(xué)意義。7、TNM分期情況為:A組Ⅰ期患者43人,占該組的75.4%,Ⅱ期患者3人,占該組的5.3%,Ⅲ期患者6人,占該組的10.5%,Ⅳ期患者5人,占該組8.8%;B組Ⅰ期患者35人,占該組的30.2%,Ⅱ期患者24人,占該組20.7%,Ⅲ期患者39人,占該組的33.6%,Ⅳ期患者18人,占該組的15.5%。A組Ⅰ/Ⅱ期患者46人,占該組80.7%;B組Ⅰ/Ⅱ期患者59人,占該組50.9%,P0.000,差異有統(tǒng)計(jì)學(xué)意義。結(jié)論:橋本氏甲狀腺炎合并甲狀腺乳頭狀癌更好發(fā)于女性患者,術(shù)前TSH水平明顯高于單純PTC患者,該指標(biāo)可能協(xié)助區(qū)分兩種疾病,并且具有腫瘤直徑更小、中央組淋巴結(jié)轉(zhuǎn)移率更低、臨床分期更早的特點(diǎn),提示HT可能起到限制PTC原發(fā)灶生長(zhǎng)及淋巴結(jié)轉(zhuǎn)移的作用。
[Abstract]:Objective: to investigate the clinical features of Hashimoto's thyroiditis complicated with papillary thyroid carcinoma, more and more cases of Hashimoto's thyroiditis complicated with thyroid papillary carcinoma have been found in order to explore the clinical characteristics of Hashimoto's thyroiditis with thyroid papillary carcinoma.It is compared with simple papillary thyroid carcinoma in order to deepen the understanding of the disease and provide evidence for better diagnosis, treatment and prognosis evaluation.Methods: a total of 57 patients with Hashimoto's thyroiditis complicated with thyroid papillary carcinoma from November 2015 to November 2016 in Shanxi Cancer Hospital affiliated to Shanxi Medical University were analyzed retrospectively.116 cases of papillary thyroid carcinoma were divided into group B.The characteristics of sex, age, tumor size, preoperative TSH level, the incidence of microcarcinoma and the lymph node metastasis rate in central group were compared between the two groups.Results there were 50 female patients in group A and 76 cases in group B.鍗犺緇，

本文編號(hào)：1703529