本文選題：2型糖尿病　切入點(diǎn)：糖化血紅蛋白　出處：《青海大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的探討西寧地區(qū)高危人群應(yīng)用空腹血糖(FPG)、餐后兩小時(shí)血糖(2h PG)、糖化血紅蛋白(Hb A1c)診斷2型糖尿病(T2DM)的優(yōu)劣性以及其靈敏度的比較;糖化血紅蛋白(Hb A1c)診斷T2DM的切點(diǎn)值。方法收集西寧地區(qū)就診人群中的糖尿病高危人群,通過入選標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn),297例(男192例,女105例)入選為研究對象,男性平均年齡50.6±11.67歲;女性平均年齡56.93±9.85歲,研究對象均進(jìn)行葡萄糖耐量(OGTT)試驗(yàn),同時(shí)測定糖化血紅蛋白(HbA1c)。結(jié)果①根據(jù)WHO關(guān)于T2DM標(biāo)準(zhǔn),297例中T2DM,192例,糖代謝異常(IGR),42例,正常糖耐量(NGT)63例;②受試者工作曲線(ROC曲線)結(jié)果:2hPG曲線下面積:0.996(95%CI 0.988~1.000),FPG曲線下面積:0.980(95%CI 0.966~0.995),HbA1c曲線下面積:0.952(95%CI 0.927~0.977);③ROC曲線分析,西寧地區(qū)HbA1c診斷T2DM的最佳切點(diǎn)為6.25%,此時(shí)的敏感度90.1%,特異度87.3%,陽性預(yù)測值95.6%,陰性預(yù)測值74.3%;FPG≥7.0mmol/L診斷T2DM時(shí),靈敏度65.1%,特異度100%,陽性預(yù)測值100%,陰性預(yù)測值48.5%,2hPG≥11.1mmol/L診斷T2DM時(shí),靈敏度96.9%,特異度100%,陽性預(yù)測值100%,陰性預(yù)測值91.3%。結(jié)論①應(yīng)用FPG診斷T2DM優(yōu)于HbA1c,但其漏診率較高;②西寧地區(qū)HbA1c斷T2DM的切點(diǎn)值為6.25%;③應(yīng)用HbA1c≥6.25%診斷糖尿病比應(yīng)用FPG≥7.0mmol/L的靈敏度高,與2hPG≥11.1mmol/L診斷T2DM的靈敏度相似。
[Abstract]:Objective to explore the advantages and disadvantages and sensitivity of fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h) and HbA1c (HbA1c) in the diagnosis of type 2 diabetes mellitus (T2DM) in high risk population in Xining area. Methods A total of 297 patients (192 males and 105 females) with high risk of diabetes mellitus in Xining area were enrolled in the study. The mean age of males was 50.6 鹵11.67 years old. The mean age of female was 56.93 鹵9.85 years old. All the subjects were tested with OGTT, and HbA1cU was determined simultaneously. Results 1 according to WHO standard, there were 192 cases of T2DMN and 42 cases of abnormal glucose metabolism. Results: the area under the 2 hPG curves was 1: 0.996 (95% CI 0.988 1.000). Under the FPG curve, the area under the FPG curve was: 0. 980, 95 CI 0. 966 and 0. 995. The area under the 1. 952 95 CI 0. 927 and 0. 977 C curves were analyzed. The best cut point for HbA1c diagnosis of T2DM in Xining area is 6.25. The sensitivity is 90.1, the specificity is 87.3, the positive predictive value is 95.6, and the negative predictive value is 74.30.The sensitivity is 65.1, the specificity is 100, the positive predictive value is 100, and the negative predictive value is 48.52hPG 鈮，

本文編號：1649381