本文選題：慢性高原病　切入點(diǎn)：大腦微結(jié)構(gòu)　出處：《實(shí)用醫(yī)學(xué)雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的:應(yīng)用擴(kuò)散峰度成像(DKI)研究慢性高原病(CMS)患者與正常人大腦灰白質(zhì)微結(jié)構(gòu)的差異。方法:收集21例CMS患者為病例組,20例健康志愿者為正常對照組,均行常規(guī)頭顱MR及DKI序列掃描,分別測量兩組大腦灰白質(zhì)各感興趣區(qū)(ROI)內(nèi)的平均峰度(MK)值、徑向峰度(RK)值及峰度各向異性(KA)值,分別統(tǒng)計(jì)各組同一部位左右兩側(cè)ROI參數(shù),符合正態(tài)分布,采用配對樣本t檢驗(yàn);統(tǒng)計(jì)兩組間同側(cè)同一部位ROI參數(shù),符合正態(tài)分布,采用兩獨(dú)立樣本t檢驗(yàn)。結(jié)果:同組比較,CMS組兩側(cè)內(nèi)囊前肢KA值及兩側(cè)尾狀核頭、丘腦MK值、RK值存在側(cè)別差;對照組兩側(cè)內(nèi)囊前肢MK值、KA值及丘腦MK值、RK值存在側(cè)別差;兩組的右側(cè)內(nèi)囊前肢的KA值較對側(cè)減低,右側(cè)丘腦MK及RK值較對側(cè)增高。兩組間對比,胼胝體膝部RK值有顯著性,CMS組低于對照組;胼胝體壓部KA值、左側(cè)內(nèi)囊前肢MK值、左側(cè)內(nèi)囊后肢RK值、右側(cè)尾狀核頭MK值、雙側(cè)豆?fàn)詈薓K值及右側(cè)丘腦MK值、KA值差異有顯著性,CMS組高于對照組。結(jié)論:高海拔地區(qū)正常人及CMS患者左右大腦半球微結(jié)構(gòu)并非完全對稱,部分腦區(qū)存在差異。CMS患者腦組織對高原低氧環(huán)境敏感性及反應(yīng)性不一,胼胝體、基底節(jié)區(qū)及丘腦與正常組均有不同程度差異性。
[Abstract]:Objective: to study the difference of brain gray matter microstructure between patients with chronic altitude disease (CMSS) and normal subjects by using diffusion kurtosis imaging (DKI). Methods: 21 CMS patients were collected as case group and 20 healthy volunteers as control group. The mean kurtosis, radial kurtosis, kurtosis and kurtosis anisotropic kurtosis were measured by routine cranial Mr and DKI sequences respectively. The ROI parameters of the left and right sides of each group were counted. According to normal distribution, paired sample t test was used, ROI parameters in the same part of the same side between two groups were calculated, and two independent samples t test were used. Results: the Ka value of anterior limb of bilateral internal capsule and the head of caudate nucleus were compared in the same group. The MK value of the thalamus and the RK value of the anterior limb of the internal capsule in the control group were different from those of the control group, and the Ka value of the right anterior limb of the internal capsule and the MK value of the thalamus of the two groups were lower than those of the opposite side, and the values of MK and RK of the right thalamus were higher than those of the opposite side. The RK value of the genu of corpus callosum was significantly lower than that of the control group, the Ka value of the corpus callosum, the MK value of the anterior limb of the left internal capsule, the RK value of the posterior limb of the left internal capsule, and the MK value of the head of the right caudate nucleus. The MK value of bilateral lenticular nucleus and the right thalamus MK value were significantly higher in CMS group than in control group. Conclusion: the microstructures of left and right hemispheres of normal subjects and CMS patients at high altitude are not completely symmetrical. There were differences in some brain regions. The sensitivity and responsiveness of brain tissue to high altitude hypoxic environment were different in CMS patients. The corpus callosum basal ganglia and thalamus were different to different degrees from normal group.
【作者單位】： 青海省人民醫(yī)院CT室;
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本文編號：1645410