本文選題：白芍總苷　切入點(diǎn)：系統(tǒng)性硬化癥　出處：《中國中西醫(yī)結(jié)合雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的研究白芍總苷(TGP)治療系統(tǒng)性硬化癥(SSc)的臨床療效和安全性。方法將50例SSc患者隨機(jī)分為TGP聯(lián)合西藥治療組(簡稱聯(lián)合組)和單純西藥對(duì)照組(簡稱對(duì)照組),治療24周。觀察患者改良Rodnan積分、關(guān)節(jié)功能積分、齒距、雙手握力、手指溫度、IgG水平、24 h尿蛋白、肺彌散功能,并監(jiān)測藥物不良反應(yīng)。結(jié)果聯(lián)合組的總有效率92.0%(23/25)明顯高于對(duì)照組68.0%(17/25),兩組總有效率比較,差異有統(tǒng)計(jì)學(xué)意義(χ~2=4.5,P0.05);聯(lián)合組患者的齒距、手指溫度、Ig G水平、24 h尿蛋白在治療12周后即較治療前明顯改善(P0.05,P0.01),而對(duì)照組的上述4個(gè)指標(biāo)在24周后較治療前有明顯改善(P0.05,P0.01);在治療24周后,聯(lián)合組患者的齒距、手指溫度、雙手握力明顯高于對(duì)照組,IgG水平、24 h尿蛋白明顯低于對(duì)照組(P0.05,P0.01)。兩組肺彌散功能的改善差異無統(tǒng)計(jì)學(xué)意義(P0.05)。聯(lián)合組無肝功能損害(簡稱肝損)的發(fā)生,明顯低于對(duì)照組[20%(5/25)]。結(jié)論 TGP輔助治療SSc,較單用西藥總有效率高,加快且優(yōu)化24周后的療效,降低肝損的發(fā)生率。
[Abstract]:Objective to study the clinical efficacy and safety of total glucoside of paeony (TGP) in the treatment of systemic sclerosis (SSC). Methods 50 patients with SSc were randomly divided into two groups: TGP combined with western medicine (combined group) and simple western medicine control group (control group). After 24 weeks of treatment, the modified Rodnan score was observed. The joint function score, tooth pitch, grip strength of both hands, finger temperature and IgG level of 24 h urine protein, pulmonary diffusive function, and adverse drug reactions were monitored. Results the total effective rate of the combined group was 92.0 鹵23 / 25) significantly higher than that of the control group (68.0% / 25%), and the total effective rate of the two groups was higher than that of the control group, and the total effective rate of the two groups was higher than that of the control group. The difference was statistically significant (蠂 ~ (2 +) 4.5U P 0.05), and the tooth pitch of the patients in the combined group was higher than that in the control group (P < 0.05). After 12 weeks of treatment, urinary protein of 24 h was significantly improved compared with that before treatment, while the above four indexes in the control group were significantly improved after 24 weeks compared with those before treatment. After 24 weeks of treatment, the tooth pitch and finger temperature of the patients in the combined group were significantly improved. The grip strength of both hands was significantly higher than that of the control group. The 24 h urinary protein level in the control group was significantly lower than that in the control group (P 0.05 and P 0.01). There was no significant difference in the improvement of pulmonary diffusive function between the two groups (P 0.05). There was no liver function damage in the combined group. Conclusion the total effective rate of TGP adjuvant therapy is higher than that of western medicine alone. It can accelerate and optimize the curative effect after 24 weeks and reduce the incidence of liver damage.
【作者單位】： 南京中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院中西醫(yī)結(jié)合臨床學(xué)系;南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院風(fēng)濕免疫科;南京中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院中醫(yī)內(nèi)科學(xué)系;
【基金】：國家自然科學(xué)基金面上項(xiàng)目(No.81473607)
【分類號(hào)】：R593.2

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