本文選題：糖尿病　切入點：型　出處：《中國糖尿病雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的探討血清25-羥維生素D[25(OH)D]與T2DM合并非酒精性脂肪性肝病(NAFLD)與糖代謝和相關生化指標的關系,以及其對進展性肝纖維化的影響。方法采集T2DM合并NAFLD患者(NAFLD組,n=380)、單純T2DM患者(T2DM組,n=130)及體檢健康者(NC組,n=130)臨床資料及血清25(OH)D,計算NAFLD組肝纖維化評分(NFS),同時測定血糖參數(shù)。結果 NAFLD組血清25(OH)D低于T2DM組及NC組[(11.95±6.46)vs(13.95±7.06)vs(18.58±3.71)ng/L,P0.05)]。多元回歸分析顯示,NAFLD組尿素是25(OH)D的獨立保護因素,AST/ALT、24 h尿微量白蛋白(24 hMAU)是其獨立危險因素。除NFS公式中所含因素外,25(OH)D、ALT是進展性肝纖維化的獨立保護因素,Scr是其獨立危險因素。結論與T2DM患者和健康人群比較,T2DM合并NAFLD患者血清25(OH)D更低,且存在更高發(fā)生進展性肝纖維化的風險。
[Abstract]:Objective to investigate the relationship between serum 25-hydroxyvitamin D (25-hydroxyvitamin D) and T2DM with nonalcoholic fatty liver disease (NAFLDD), glucose metabolism and related biochemical indexes. Methods the clinical data of patients with T2DM combined with NAFLD (n = 380), simple T2DM (n = 130) and normal control (NC) (n = 130) were collected and the serum 25 OHH D was collected. The hepatic fibrosis score of NAFLD group was calculated and the blood glucose was measured at the same time. Results the serum 25 OHH D in NAFLD group was lower than that in T2DM group and NC group [11.95 鹵6.46 VSD 13.95 鹵7.06 ng / L P 0.05]. Multivariate regression analysis showed that urea was the independent protective factor of 25 OHH D in NAFLD group. SCR is an independent protective factor for progressive hepatic fibrosis. Conclusion compared with the patients with T2DM and healthy people, the serum level of T2DM with NAFLD is lower than that of T2DM with NAFLD. And there is a higher risk of progressive liver fibrosis.
【作者單位】： 遵義醫(yī)學院附屬醫(yī)院內(nèi)分泌科;黔東南州人民醫(yī)院兒科;
【基金】：國家自然科學基金(81560147) 貴州省科技攻關項目[黔科合SY字(2012)3116號] 貴州省科學技術基金[黔科合J字LKZ(2013)53號] 遵義醫(yī)學院博士啟動基金(F-588)
【分類號】：R575.5;R587.1

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本文編號：1636137