發(fā)布時(shí)間：2018-03-19 21:45

  本文選題：糖尿病　切入點(diǎn)：型　出處：《中國(guó)糖尿病雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的探討血清25-羥維生素D[25(OH)D]與T2DM合并非酒精性脂肪性肝病(NAFLD)與糖代謝和相關(guān)生化指標(biāo)的關(guān)系,以及其對(duì)進(jìn)展性肝纖維化的影響。方法采集T2DM合并NAFLD患者(NAFLD組,n=380)、單純T2DM患者(T2DM組,n=130)及體檢健康者(NC組,n=130)臨床資料及血清25(OH)D,計(jì)算NAFLD組肝纖維化評(píng)分(NFS),同時(shí)測(cè)定血糖參數(shù)。結(jié)果 NAFLD組血清25(OH)D低于T2DM組及NC組[(11.95±6.46)vs(13.95±7.06)vs(18.58±3.71)ng/L,P0.05)]。多元回歸分析顯示,NAFLD組尿素是25(OH)D的獨(dú)立保護(hù)因素,AST/ALT、24 h尿微量白蛋白(24 hMAU)是其獨(dú)立危險(xiǎn)因素。除NFS公式中所含因素外,25(OH)D、ALT是進(jìn)展性肝纖維化的獨(dú)立保護(hù)因素,Scr是其獨(dú)立危險(xiǎn)因素。結(jié)論與T2DM患者和健康人群比較,T2DM合并NAFLD患者血清25(OH)D更低,且存在更高發(fā)生進(jìn)展性肝纖維化的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the relationship between serum 25-hydroxyvitamin D (25-hydroxyvitamin D) and T2DM with nonalcoholic fatty liver disease (NAFLDD), glucose metabolism and related biochemical indexes. Methods the clinical data of patients with T2DM combined with NAFLD (n = 380), simple T2DM (n = 130) and normal control (NC) (n = 130) were collected and the serum 25 OHH D was collected. The hepatic fibrosis score of NAFLD group was calculated and the blood glucose was measured at the same time. Results the serum 25 OHH D in NAFLD group was lower than that in T2DM group and NC group [11.95 鹵6.46 VSD 13.95 鹵7.06 ng / L P 0.05]. Multivariate regression analysis showed that urea was the independent protective factor of 25 OHH D in NAFLD group. SCR is an independent protective factor for progressive hepatic fibrosis. Conclusion compared with the patients with T2DM and healthy people, the serum level of T2DM with NAFLD is lower than that of T2DM with NAFLD. And there is a higher risk of progressive liver fibrosis.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院內(nèi)分泌科;黔東南州人民醫(yī)院兒科;
【基金】：國(guó)家自然科學(xué)基金(81560147) 貴州省科技攻關(guān)項(xiàng)目[黔科合SY字(2012)3116號(hào)] 貴州省科學(xué)技術(shù)基金[黔科合J字LKZ(2013)53號(hào)] 遵義醫(yī)學(xué)院博士啟動(dòng)基金(F-588)
【分類號(hào)】：R575.5;R587.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 Myrto Eliades;Elias Spyrou;;Vitamin D:A new player in non-alcoholic fatty liver disease?[J];World Journal of Gastroenterology;2015年06期

【共引文獻(xiàn)】

相關(guān)期刊論文 前5條

1 葉凡豪;楊孟雪;李顯文;龍彪;楊波;李思成;李鳳萍;安小娟;李婭;代敏;;糖尿病合并非酒精性脂肪性肝病患者血清25-羥維生素D水平的變化及其臨床意義[J];中國(guó)糖尿病雜志;2017年07期

2 Flavia A Cimini;Ilaria Barchetta;Simone Carotti;Laura Bertoccini;Marco G Baroni;Umberto Vespasiani-Gentilucci;Ilaria Barchetta;Maria-Gisella Cavallo;Sergio Morini;;Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease[J];World Journal of Gastroenterology;2017年19期

3 Alia S Dadabhai;Behnam Saberi;Katie Lobner;Russell T Shinohara;Gerard E Mullin;;Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data[J];World Journal of Hepatology;2017年05期

4 Ludovico Abenavoli;Natasa Milic;Laura Di Renzo;Tomislav Preveden;Milica Medi?-Stojanoska;Antonino De Lorenzo;;Metabolic aspects of adult patients with nonalcoholic fatty liver disease[J];World Journal of Gastroenterology;2016年31期

5 Laura Marino;Fran?ois R Jornayvaz;;Endocrine causes of nonalcoholic fatty liver disease[J];World Journal of Gastroenterology;2015年39期

，

本文編號(hào)：1636137