發(fā)布時(shí)間：2018-03-18 12:01

  本文選題：骨疏康膠囊　切入點(diǎn)：糖皮質(zhì)激素性骨質(zhì)疏松癥　出處：《中國(guó)骨質(zhì)疏松雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的觀察骨疏康膠囊治療糖皮質(zhì)激素性骨質(zhì)疏松癥的療效。方法選取寧夏醫(yī)科大學(xué)總醫(yī)院門(mén)診及住院確診的風(fēng)濕性疾病并糖皮質(zhì)激素性骨質(zhì)疏松癥患者80例,隨機(jī)分為試驗(yàn)組和對(duì)照組,每組各40例。試驗(yàn)組患者口服骨疏康膠囊4粒BID,阿法骨化醇軟膠囊0.5μg QD,碳酸鈣D3片1片BID,對(duì)照組患者口服阿法骨化醇軟膠囊0.5μg QD,碳酸鈣D3片1片BID,兩組均連續(xù)用藥12個(gè)月,觀察其骨密度及骨代謝指標(biāo)的變化。結(jié)果試驗(yàn)組腰椎(L1~4)、股骨頸、大轉(zhuǎn)子、全髖的骨密度均較對(duì)照組升高,與治療前相比明顯升高,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。骨代謝指標(biāo)中,試驗(yàn)組血清鈣治療前后無(wú)明顯變化(P0.05),骨鈣素、堿性磷酸酶降低,25-羥維生素D、Ⅰ型前膠原N端前肽升高,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。與對(duì)照組比較,血清鈣與骨鈣素?zé)o明顯變化(P0.05),堿性磷酸酶降低,25-羥維生素D、Ⅰ型前膠原N端前肽升高,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論骨疏康膠囊可改善糖皮質(zhì)激素性骨質(zhì)疏松癥患者的骨密度和骨代謝,具有臨床使用價(jià)值。
[Abstract]:Objective to observe the curative effect of Gushukang capsule on glucocorticoid-induced osteoporosis. Methods 80 patients with rheumatic diseases and glucocorticoid osteoporosis were selected from outpatient and inpatient department of Ningxia Medical University General Hospital. They were randomly divided into two groups: experimental group and control group. There were 40 cases in each group. The patients in the test group were treated with BID4 tablets of Guxukang capsule, 0.5 渭 g QDof Alfacalcitrate soft capsule, 1 tablet of calcium carbonate D3, and 1 tablet of BID1 of Alfacalciferol soft capsule and calcium carbonate D3 tablet in the control group. The two groups were treated continuously for 12 months, and the patients in the control group were treated by oral administration of 0.5 渭 g QD and 1 tablet of calcium carbonate in the control group. Results the bone mineral density (BMD) of the lumbar spine, femoral neck, trochanter and total hip in the experimental group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). There were no significant changes in serum calcium, osteocalcin and alkaline phosphatase in the experimental group before and after treatment. The levels of 25-hydroxyvitamin D and procollagen 鈪，

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