發(fā)布時(shí)間：2018-03-16 22:05

  本文選題：瘦素受體　切入點(diǎn)：單核苷酸基因多態(tài)性　出處：《衛(wèi)生研究》2017年03期 　論文類型：期刊論文

【摘要】：目的探討漢族老年人糖尿病與瘦素受體基因rs1137100和rs1137101多態(tài)性位點(diǎn)(SNP)的相關(guān)性。方法采用Taqman方法檢測(cè)241例漢族老年人糖尿病患者和270例漢族健康老年人的瘦素受體基因rs1137100和rs1137101基因型及等位基因頻率分布狀況,分析各SNP位點(diǎn)基因型與糖尿病的相關(guān)性,同時(shí)測(cè)定所有研究對(duì)象的血脂、血糖、血漿瘦素和胰島素水平。結(jié)果 rs1137100位點(diǎn)GG、GA和AA基因型在糖尿病組和正常對(duì)照組之間的分布頻率分別為73.0%、24.5%、2.5%和68.9%、28.9%和2.2%,兩組之間差異無統(tǒng)計(jì)學(xué)意義(χ~2=1.27,P=0.53);A等位基因在兩組間的分布頻率分別是14.7%和16.7%,兩組之間差異無統(tǒng)計(jì)學(xué)意義(χ~2=0.72,P=0.40)。rs1137101位點(diǎn)上GG、GA和AA基因型在糖尿病組和正常對(duì)照組之間的分布頻率分別為77.6%、21.2%、1.2%和77.8%、21.1%、1.1%,兩組之間差異無統(tǒng)計(jì)學(xué)意義(χ~2=0.02,P=0.99);A等位基因在兩組間的分布頻率分別是11.8%和11.7%,兩組之間差異無統(tǒng)計(jì)學(xué)意義(χ~2=0.01,P=0.94)。Logistic回歸分析結(jié)果表明,與GG型研究對(duì)象相比,rs1137100位點(diǎn)GA型、AA型研究對(duì)象發(fā)生糖尿病的風(fēng)險(xiǎn)相似,OR值分別為1.06(95%CI 0.34~3.34)和0.80(95%CI 0.54~1.19);在rs1137101位點(diǎn)上,與GG型研究對(duì)象相比,GA型、AA型研究對(duì)象發(fā)生糖尿病的風(fēng)險(xiǎn)相似,OR值分別為1.12(95%CI 0.22~5.63)和1.01(95%CI 0.66~1.54)。結(jié)論瘦素受體基因rs1137100和rs1137101位點(diǎn)的變異與漢族老年人糖尿病沒有明顯的相關(guān)性。
[Abstract]:Objective to investigate the relationship between leptin receptor gene (rs1137100) and leptin receptor gene polymorphism (rs1137101) in the elderly of Han nationality. Methods the leptin receptor gene was detected by Taqman in 241 elderly patients with diabetes and 270 healthy controls. Because of the frequency distribution of rs1137100 and rs1137101 genotypes and alleles, The relationship between SNP locus genotypes and diabetes mellitus was analyzed, and blood lipids and blood glucose were measured in all subjects. Results the distribution frequency of GGG GA-GA and AA genotype at rs1137100 locus between diabetic group and normal control group was 73.0% and 68.9%, respectively. There was no significant difference between the two groups (蠂 ~ (2 +) ~ (1.27) P ~ (0.53A) allele) in plasma leptin and insulin (P < 0.05). The distribution frequency of GGG GA-GA and AA genotype at rs1137100 locus in diabetic group and normal control group were 73.0% and 68.9% and 28.9% and 2.2%, respectively. There was no significant difference between the two groups. There was no significant difference between the two groups (蠂 ~ (2) 0.72 ~ (2)) P ~ (0.40). Rs1137101. The distribution frequencies of GGGGGA and AA genotype in diabetic group and normal control group were 77.6% and 77.821.21%, respectively. There was no significant difference between the two groups (蠂 ~ (2) ~ (2) 0. 02) P ~ (0.99A). The distribution frequency of alleles in the two groups was 11.8% and 11.70.There was no significant difference between the two groups (蠂 ~ 2 / 0. 01 ~ 0. 01 P 0. 94 ~ 0. 94) logistic regression analysis showed that there was no significant difference between the two groups. Compared with the GG study subjects, the OR values of risk of diabetes were 1.0695 CI 0.343.34 and 0.8095CI 0.541.19 in GA type AA subjects, respectively. Compared with the GG study subjects, the OR values of the patients with GA type AA were 1.1295 CI 0.225.63) and 1.0195% CI 0.661.54 respectively. Conclusion there is no significant correlation between the variation of rs1137100 and rs1137101 loci of leptin receptor gene and diabetes in the elderly of Han nationality.
【作者單位】： 中國(guó)疾病預(yù)防控制中心營(yíng)養(yǎng)與健康所國(guó)家衛(wèi)生計(jì)生委微量元素營(yíng)養(yǎng)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金(No.30671750)
【分類號(hào)】：R587.1

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