本文選題：中醫(yī)藥　切入點(diǎn)：骨質(zhì)疏松　出處：《福建中醫(yī)藥大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察補(bǔ)腎健脾方對(duì)骨質(zhì)疏松性骸部骨折術(shù)后肌力與骨量的影響,探討補(bǔ)腎健脾方對(duì)骨質(zhì)疏松性骨折術(shù)后骨量的影響機(jī)制,為臨床預(yù)防廢用性骨質(zhì)疏松癥提供有效依據(jù)。方法：將2014年02月01日-2014年10月15日(隨訪時(shí)間至2015.02.01)收治的骨質(zhì)疏松性股骨粗隆間骨折患者70例,隨機(jī)分為對(duì)照組與實(shí)驗(yàn)組,對(duì)照組在骨折術(shù)后常規(guī)使用鈣劑治療,實(shí)驗(yàn)組在鈣制劑治療基礎(chǔ)上加用中藥補(bǔ)腎健脾方,通過觀察肌力、骨量及生化指標(biāo)的變化,采用PASW Statistics 18.0統(tǒng)計(jì)學(xué)軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果：能夠按要求連續(xù)用藥及隨訪者56例,實(shí)驗(yàn)組27例,對(duì)照組29例。肌力比較：術(shù)后3天、7天、1個(gè)月兩組間肌力都無明顯差異(P0.05),而術(shù)后15天實(shí)驗(yàn)組肌力明顯大于對(duì)照組(P0.05)。實(shí)驗(yàn)組術(shù)后3天、7天、15天、1個(gè)月的肌力在明顯逐漸增加(P0.05)；對(duì)照組術(shù)后15天肌力與術(shù)后7天無明顯差異(P0.05),術(shù)后7天肌力比術(shù)后3天明顯增加、術(shù)后1個(gè)月肌力比術(shù)后15天明顯增加(P0.05)。骨量比較：實(shí)驗(yàn)組骨密度與骨礦含量在治療前及隨訪時(shí)都無明顯改變(P0.05),對(duì)照組骨礦含量在治療前及隨訪時(shí)也無明顯改變(P0.05),但是對(duì)照組在隨訪時(shí)骨密度值明顯降低(P0.05)。生化指標(biāo)比較：術(shù)前、術(shù)后1個(gè)月兩組間骨堿性磷酸酶無明顯差異(P0.05),術(shù)后3個(gè)月實(shí)驗(yàn)組比對(duì)照組高(P0.05)；實(shí)驗(yàn)組術(shù)后3個(gè)月比術(shù)前高(P0.05),術(shù)前與術(shù)后1個(gè)月無明顯差異(P0.05)；對(duì)照組術(shù)后1個(gè)月、術(shù)后3個(gè)月都比術(shù)前低(P0.05),術(shù)后1個(gè)月與術(shù)后3個(gè)月無明顯差異(P0.05)。術(shù)前、術(shù)后1個(gè)月兩組間肌酐無明顯差異(P0.05),術(shù)后3個(gè)月實(shí)驗(yàn)組比對(duì)照組高(P0.05)；實(shí)驗(yàn)組術(shù)后1個(gè)月與術(shù)后3個(gè)月的肌酐比術(shù)前的高(P0.05),術(shù)后3個(gè)月與術(shù)后1個(gè)月無明顯差異(P0.05)；對(duì)照組術(shù)前、術(shù)后1個(gè)月、術(shù)后3個(gè)月間都無明顯差異(P0.05)。結(jié)論：補(bǔ)腎健脾方對(duì)預(yù)防骨質(zhì)疏松性骨折術(shù)后的骨密度降低具有積極意義,可以應(yīng)用于輔助防治廢用性骨質(zhì)疏松癥。
[Abstract]:Objective: to observe the effect of Bushen Jianpi recipe on muscle strength and bone mass of osteoporotic bone fracture, and to explore the mechanism of Bushen Jianpi recipe on bone mass after osteoporosis fracture. Methods: from February 1st 2014 to October 15th 2014 (follow-up period to 2015.02.01), 70 patients with osteoporotic intertrochanteric fracture of femur were randomly divided into control group and experimental group. The control group was treated with calcium after fracture and the experimental group was treated with traditional Chinese medicine Bushen Jianpi on the basis of calcium treatment. The changes of muscle strength, bone mass and biochemical indexes were observed. PASW Statistics 18.0 software was used to carry out statistical analysis. Results: 56 cases could be used continuously and followed up according to the requirements, 27 cases in the experimental group, 27 cases in the experimental group, and 27 cases in the experimental group. Comparison of muscle strength of 29 cases in the control group: there was no significant difference in muscle strength between the two groups on the 3rd day and 7th day after operation, and there was no significant difference between the two groups in one month, but the muscle strength in the experimental group was significantly larger than that in the control group on the 15th day after operation. The muscle strength of the experimental group was significantly higher than that of the control group on the 3rd day, 7th day and 15th day. In the control group, there was no significant difference in muscle strength between 15 days after operation and 7 days after operation, and the muscle strength at 7 days after operation was significantly higher than that at 3 days after operation. Comparison of bone mass: bone mineral density and bone mineral content in the experimental group did not change significantly before treatment and during follow-up, while bone mineral content in the control group did not change significantly before treatment and at follow-up. However, the BMD of the control group decreased significantly at the follow-up period (P 0.05). There was no significant difference in bone alkaline phosphatase (BALP) between the two groups at one month after operation (P 0.05), but the levels of bone alkaline phosphatase in the experimental group were higher than those in the control group at 3 months after operation, and in the experimental group at the third month after operation, and there was no significant difference between the two groups before operation and at one month after operation, and there was no significant difference between the two groups at 1 month after operation. There was no significant difference between 1 month after operation and 3 months after operation (P 0.05). There was no significant difference in creatinine between the two groups at 1 month after operation (P 0.05), but at 3 months after operation, the level of creatinine in the experimental group was higher than that in the control group (P 0.05), and the creatinine level in the experimental group was higher than that in the control group at 1 month and 3 months after operation, and there was no significant difference between the three months after operation and one month after operation (P 0.05). Conclusion: the prescription of tonifying kidney and strengthening spleen has positive significance in preventing the decrease of bone mineral density after osteoporosis fracture, and can be used to prevent and treat waste osteoporosis.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R580;R687.3

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本文編號(hào)：1621754