本文選題：中醫(yī)藥　切入點：骨質(zhì)疏松　出處：《福建中醫(yī)藥大學》2015年碩士論文　論文類型：學位論文

【摘要】：目的：觀察補腎健脾方對骨質(zhì)疏松性骸部骨折術后肌力與骨量的影響,探討補腎健脾方對骨質(zhì)疏松性骨折術后骨量的影響機制,為臨床預防廢用性骨質(zhì)疏松癥提供有效依據(jù)。方法：將2014年02月01日-2014年10月15日(隨訪時間至2015.02.01)收治的骨質(zhì)疏松性股骨粗隆間骨折患者70例,隨機分為對照組與實驗組,對照組在骨折術后常規(guī)使用鈣劑治療,實驗組在鈣制劑治療基礎上加用中藥補腎健脾方,通過觀察肌力、骨量及生化指標的變化,采用PASW Statistics 18.0統(tǒng)計學軟件進行統(tǒng)計分析。結果：能夠按要求連續(xù)用藥及隨訪者56例,實驗組27例,對照組29例。肌力比較：術后3天、7天、1個月兩組間肌力都無明顯差異(P0.05),而術后15天實驗組肌力明顯大于對照組(P0.05)。實驗組術后3天、7天、15天、1個月的肌力在明顯逐漸增加(P0.05)；對照組術后15天肌力與術后7天無明顯差異(P0.05),術后7天肌力比術后3天明顯增加、術后1個月肌力比術后15天明顯增加(P0.05)。骨量比較：實驗組骨密度與骨礦含量在治療前及隨訪時都無明顯改變(P0.05),對照組骨礦含量在治療前及隨訪時也無明顯改變(P0.05),但是對照組在隨訪時骨密度值明顯降低(P0.05)。生化指標比較：術前、術后1個月兩組間骨堿性磷酸酶無明顯差異(P0.05),術后3個月實驗組比對照組高(P0.05)；實驗組術后3個月比術前高(P0.05),術前與術后1個月無明顯差異(P0.05)；對照組術后1個月、術后3個月都比術前低(P0.05),術后1個月與術后3個月無明顯差異(P0.05)。術前、術后1個月兩組間肌酐無明顯差異(P0.05),術后3個月實驗組比對照組高(P0.05)；實驗組術后1個月與術后3個月的肌酐比術前的高(P0.05),術后3個月與術后1個月無明顯差異(P0.05)；對照組術前、術后1個月、術后3個月間都無明顯差異(P0.05)。結論：補腎健脾方對預防骨質(zhì)疏松性骨折術后的骨密度降低具有積極意義,可以應用于輔助防治廢用性骨質(zhì)疏松癥。
[Abstract]:Objective: to observe the effect of Bushen Jianpi recipe on muscle strength and bone mass of osteoporotic bone fracture, and to explore the mechanism of Bushen Jianpi recipe on bone mass after osteoporosis fracture. Methods: from February 1st 2014 to October 15th 2014 (follow-up period to 2015.02.01), 70 patients with osteoporotic intertrochanteric fracture of femur were randomly divided into control group and experimental group. The control group was treated with calcium after fracture and the experimental group was treated with traditional Chinese medicine Bushen Jianpi on the basis of calcium treatment. The changes of muscle strength, bone mass and biochemical indexes were observed. PASW Statistics 18.0 software was used to carry out statistical analysis. Results: 56 cases could be used continuously and followed up according to the requirements, 27 cases in the experimental group, 27 cases in the experimental group, and 27 cases in the experimental group. Comparison of muscle strength of 29 cases in the control group: there was no significant difference in muscle strength between the two groups on the 3rd day and 7th day after operation, and there was no significant difference between the two groups in one month, but the muscle strength in the experimental group was significantly larger than that in the control group on the 15th day after operation. The muscle strength of the experimental group was significantly higher than that of the control group on the 3rd day, 7th day and 15th day. In the control group, there was no significant difference in muscle strength between 15 days after operation and 7 days after operation, and the muscle strength at 7 days after operation was significantly higher than that at 3 days after operation. Comparison of bone mass: bone mineral density and bone mineral content in the experimental group did not change significantly before treatment and during follow-up, while bone mineral content in the control group did not change significantly before treatment and at follow-up. However, the BMD of the control group decreased significantly at the follow-up period (P 0.05). There was no significant difference in bone alkaline phosphatase (BALP) between the two groups at one month after operation (P 0.05), but the levels of bone alkaline phosphatase in the experimental group were higher than those in the control group at 3 months after operation, and in the experimental group at the third month after operation, and there was no significant difference between the two groups before operation and at one month after operation, and there was no significant difference between the two groups at 1 month after operation. There was no significant difference between 1 month after operation and 3 months after operation (P 0.05). There was no significant difference in creatinine between the two groups at 1 month after operation (P 0.05), but at 3 months after operation, the level of creatinine in the experimental group was higher than that in the control group (P 0.05), and the creatinine level in the experimental group was higher than that in the control group at 1 month and 3 months after operation, and there was no significant difference between the three months after operation and one month after operation (P 0.05). Conclusion: the prescription of tonifying kidney and strengthening spleen has positive significance in preventing the decrease of bone mineral density after osteoporosis fracture, and can be used to prevent and treat waste osteoporosis.
【學位授予單位】：福建中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R580;R687.3

【參考文獻】

相關期刊論文 前3條

1 林燕萍,周瑞祥,張愛平,黃美雅;健骨顆粒對去卵巢骨質(zhì)疏松模鼠骨組織結構的影響[J];解剖學雜志;2001年06期

2 林燕萍,李詠高,王和鳴,黃美雅;健骨顆粒對骨質(zhì)疏松模鼠垂體-甲狀腺軸的影響[J];中國骨傷;2002年03期

3 何敏;伍春;明海霞;侯茜;張帆;;甘肅黨參水煎劑對D-半乳糖誘導衰老小鼠免疫功能的影響[J];細胞與分子免疫學雜志;2013年08期

，

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