發(fā)布時(shí)間：2018-03-15 01:11

  本文選題：跑臺(tái)運(yùn)動(dòng)　切入點(diǎn)：阿霉素　出處：《中國骨質(zhì)疏松雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的研究阿霉素(doxorubicin,DOX)和醋酸戈舍瑞林(goserelin acetate,GA)聯(lián)合作用對(duì)大鼠骨密度和骨代謝的影響,以及跑臺(tái)運(yùn)動(dòng)對(duì)DOX聯(lián)合GA誘導(dǎo)的大鼠骨質(zhì)疏松的防治效果。方法 8周齡雌性SD大鼠64只,被隨機(jī)分為8組,每組8只:安靜對(duì)照組(SED)、DOX干預(yù)組(SED+DOX)、GA干預(yù)組(SED+GA)、DOX和GA聯(lián)合干預(yù)組(SED+DOX+GA)、跑臺(tái)運(yùn)動(dòng)對(duì)照組(EX)、跑臺(tái)運(yùn)動(dòng)結(jié)合DOX干預(yù)組(EX+DOX)、跑臺(tái)運(yùn)動(dòng)結(jié)合GA干預(yù)組(EX+GA)、跑臺(tái)運(yùn)動(dòng)結(jié)合DOX和GA聯(lián)合干預(yù)組(EX+DOX+GA)。藥物和跑臺(tái)運(yùn)動(dòng)干預(yù)周期均為8周,8周后測試所有大鼠左側(cè)股骨骨密度和血清骨代謝指標(biāo)。結(jié)果與其相對(duì)應(yīng)的非藥物干預(yù)各組相比較,藥物干預(yù)各組大鼠骨密度顯著降低、骨形成指標(biāo)ALP和BGP顯著降低而骨吸收指標(biāo)Ca2+和TRACP5b顯著升高;與DOX單獨(dú)干預(yù)組及GA單獨(dú)干預(yù)組相比較,DOX和GA聯(lián)合干預(yù)組大鼠骨密度顯著降低、骨形成指標(biāo)ALP和BGP顯著降低而骨吸收指標(biāo)Ca2+和TRACP5b顯著升高;與其相對(duì)應(yīng)的安靜組相比較,跑臺(tái)運(yùn)動(dòng)各組大鼠骨密度顯著升高、骨形成指標(biāo)ALP和BGP顯著升高而骨吸收指標(biāo)Ca2+和TRACP5b顯著降低。結(jié)論 DOX和GA單獨(dú)或聯(lián)合作用均可導(dǎo)致大鼠骨質(zhì)疏松癥的發(fā)生,且DOX和GA聯(lián)合作用誘導(dǎo)大鼠骨質(zhì)疏松的程度顯著大于DOX或GA單獨(dú)作用的結(jié)果;跑臺(tái)運(yùn)動(dòng)可以有效降低DOX和GA單獨(dú)或聯(lián)合作用誘導(dǎo)的大鼠骨質(zhì)疏松。
[Abstract]:Objective to study the adriamycin (doxorubicin, DOX) and Gore Sherry Lin (goserelin acetate, GA acetate) combined effects on bone density and bone metabolism in rats, and the control effect of treadmill exercise on DOX combined with GA induced osteoporosis rats. Methods 8 week old female SD 64 rats were randomly divided into 8 group, 8 rats in each group: control group (SED), DOX group (SED+DOX), GA group (SED+GA), DOX and GA treatment group (SED+DOX+GA), treadmill exercise control group (EX), treadmill exercise combined with DOX intervention group (EX+DOX), treadmill exercise intervention combined with GA group (EX+GA), treadmill exercise combined with DOX and GA treatment group (EX+DOX+GA). Drugs and treadmill exercise intervention period was 8 weeks, 8 weeks after the test of all the rats left femur bone mineral density and bone metabolism indexes. Non drug intervention groups compared with the corresponding results, drug intervention groups the bone density was significantly decreased, bone formation As indicators of ALP and BGP significantly decreased and the bone absorption index of Ca2+ and TRACP5b were significantly increased; with DOX alone GA alone intervention group and intervention group compared, DOX and GA combined intervention group rats significantly decreased bone density, bone formation index ALP and BGP significantly decreased and the bone absorption index of Ca2+ and TRACP5b significantly increased; and the relative should the quiet group compared with treadmill exercise rats significantly increased the bone density, bone formation index ALP and BGP were significantly increased and the bone resorption index of Ca2+ and TRACP5b decreased significantly. Conclusion DOX and GA alone or in combination can lead to osteoporosis rats occurred, and the combined effects of DOX and GA induced rats osteoporosis was significantly higher than DOX or GA alone. Results; treadmill exercise can effectively reduce the induction of DOX and GA alone or in combination with the function of rats with osteoporosis.

【作者單位】： 山東體育學(xué)院;齊魯師范學(xué)院;
【基金】：國家體育總局全民健身研究領(lǐng)域課題(2015B059);國家體育總局體育哲學(xué)社會(huì)科學(xué)研究項(xiàng)目(2292SS16029)
【分類號(hào)】：R580
，

本文編號(hào)：1613754