本文選題：類風(fēng)濕關(guān)節(jié)炎　切入點(diǎn)：單核苷酸多態(tài)性　出處：《廣東醫(yī)學(xué)》2016年07期 　論文類型：期刊論文

【摘要】：目的探討5種單核苷酸多態(tài)性(SNP)與漢族人群類風(fēng)濕關(guān)節(jié)炎(RA)易感性的關(guān)系。方法收集91例RA患者和100例健康人血液標(biāo)本,利用基因測(cè)序法檢測(cè)rs2230926、rs7574865、rs3761847、rs2228145和rs2234067等5種SNPs,同時(shí)用ELISA法檢測(cè)RA患者的血清抗CCP。分為RA組和對(duì)照組進(jìn)行病例對(duì)照研究。結(jié)果 (1)5種SNP在對(duì)照組和RA組中的分布均符合Hardy-Weinberg平衡(P0.05)。rs3761847和rs2228145的不同等位基因頻率與RA的易感性顯著相關(guān)[OR(95%CI)分別為1.61(1.07~2.41)、0.64(0.42~0.97),P0.05],rs7574865、rs2234067及rs2230926與RA的易感性未見(jiàn)顯著相關(guān)(P0.05)。(2)rs2228145與RA患者血清抗CCP反應(yīng)性顯著相關(guān)(P=0.014 9),其C等位基因頻率在兩組中的差異有統(tǒng)計(jì)學(xué)意義(P0.05);而rs2228145及rs3761847與RA患者血清RF反應(yīng)性、rs3761847與RA患者血清抗CCP反應(yīng)性均無(wú)顯著相關(guān)(P0.05)。結(jié)論廈門(mén)地區(qū)漢族人rs3761847和rs2228145基因多態(tài)性可能與RA的易感性存在關(guān)聯(lián),而rs7574865、rs2234067及rs2230926則與RA的易感性可能無(wú)關(guān)。
[Abstract]:Objective to investigate the 5 single nucleotide polymorphisms (SNP) and rheumatoid arthritis in Han population (RA) susceptibility. Methods 91 patients with RA and 100 healthy human blood samples, using gene sequencing to detect rs2230926, rs7574865, rs3761847, rs2228145 and rs2234067 5 SNPs, and ELISA was used to detect serum RA the anti CCP. were divided into RA group and control group. The results of a case-control study (1) of 5 SNP in the distribution in the control group and RA group were in accordance with Hardy-Weinberg balance (P0.05) of different allele frequency with RA.Rs3761847 and rs2228145 [OR were significantly related to the susceptibility (95%CI) were 1.61 (1.07~2.41) 0.64, (0.42~0.97), P0.05], rs7574865, rs2234067 and rs2230926 were significantly correlated with the susceptibility of RA (P0.05). (2) rs2228145 and RA in sera of patients with anti CCP reactivity was significantly correlated (P=0.014 9), the difference of the frequency of C allele in the two groups in the Statistical significance (P0.05); and rs2228145 and rs3761847 and RF in serum of patients with RA reactivity, rs3761847 and serum RA response was not significantly associated with anti CCP (P0.05). Conclusion rs3761847 in Han nationality in Xiamen area and rs2228145 gene polymorphism may be associated with the susceptibility to RA, rs7574865, rs2234067 and rs2230926 and RA susceptibility may have nothing to do.

【作者單位】： 福建省廈門(mén)市中醫(yī)院檢驗(yàn)科;福建省廈門(mén)市中醫(yī)院風(fēng)濕免疫科;
【基金】：福建省自然科學(xué)基金面上項(xiàng)目(編號(hào):2013D007)
【分類號(hào)】：R593.22

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 孫麗霞;轉(zhuǎn)化生長(zhǎng)因子-β1與類風(fēng)濕關(guān)節(jié)炎[J];河北醫(yī)科大學(xué)學(xué)報(bào);2002年05期

2 董振華;類風(fēng)濕關(guān)節(jié)炎的社區(qū)預(yù)防及健康指導(dǎo)[J];中國(guó)全科醫(yī)學(xué);2002年09期

3 馬麗;類風(fēng)濕關(guān)節(jié)炎的治療進(jìn)展[J];中國(guó)全科醫(yī)學(xué);2002年09期

4 朱遠(yuǎn)豐;類風(fēng)濕關(guān)節(jié)炎發(fā)病的分子機(jī)制與相關(guān)療法[J];實(shí)用醫(yī)學(xué)雜志;2002年12期

5 陳文蓉,李賀;類風(fēng)濕關(guān)節(jié)炎的化驗(yàn)檢查[J];中國(guó)社區(qū)醫(yī)師;2002年17期

6 周廣宇,王茜,畢黎琦;類風(fēng)濕關(guān)節(jié)炎的發(fā)病機(jī)理[J];中國(guó)社區(qū)醫(yī)師;2002年17期

7 劉波;類風(fēng)濕關(guān)節(jié)炎的關(guān)節(jié)表現(xiàn)[J];中國(guó)社區(qū)醫(yī)師;2002年17期

8 陳志營(yíng);類風(fēng)濕關(guān)節(jié)炎的關(guān)節(jié)外表現(xiàn)[J];中國(guó)社區(qū)醫(yī)師;2002年17期

9 劉鋒,周廣宇;類風(fēng)濕關(guān)節(jié)炎的診斷[J];中國(guó)社區(qū)醫(yī)師;2002年17期

10 周宇t，

本文編號(hào)：1613280