本文選題：雄激素受體　切入點：基因多態(tài)性　出處：《西安交通大學學報(醫(yī)學版)》2017年03期 　論文類型：期刊論文

【摘要】：目的研究雄激素受體(AR)基因第一外顯子內(nèi)CAG重復序列長度多態(tài)性與男性代謝綜合征(MS)及其組成成分的相關性。方法采用整群抽樣法,選擇寧夏吳忠市和銀川市中老年男性910例。測量其身高、體質(zhì)量、血壓,檢測睪酮(TT)、血脂、空腹血糖(FBG)、空腹胰島素(FINS)水平,計算體質(zhì)量指數(shù)(BMI)和游離睪酮(FT),使用聚合酶鏈反應(PCR)和直接測序法測定外周血AR基因CAG重復序列長度。根據(jù)是否患有MS分為MS組(共304例)和正常對照組(共606例)。結(jié)果正常對照組與MS組的AR基因CAG重復序列長度多態(tài)性的頻率分布無明顯差異。CAG重復序列數(shù)22組的收縮壓顯著高于CAG重復序列數(shù)≥22組,而高密度脂蛋白(HDL-C)濃度顯著低于CAG重復序列數(shù)≥22組。但兩組間的舒張壓、其他血脂水平、FBG、FINS、BMI、TT、FT指標均沒有統(tǒng)計學差異。CAG重復序列數(shù)22組較CAG重復序列數(shù)≥22組有更高的高血壓患病率,但是兩組之間的MS及其他組成成分疾病的患病率并無統(tǒng)計學差異。結(jié)論 AR基因CAG重復序列長度多態(tài)性與高血壓病和HDL-C水平降低的發(fā)生有關,但是與MS的患病率無關。AR基因外顯子一CAG重復序列數(shù)目22可能是患高血壓病和HDL-C水平降低的遺傳因素。
[Abstract]:Objective to study the relationship between CAG repeat length polymorphism in exon 1 of androgen receptor receptor gene and male metabolic syndrome (MS) and its components. The body height, body mass, blood pressure, testosterone TTX, blood lipid, fasting blood glucose (FBGG) and fasting insulin (FINS) were measured in 910 middle-aged and aged males in Wuzhong and Yinchuan, Ningxia. The CAG repeat length of AR gene in peripheral blood was determined by polymerase chain reaction (PCR) and direct sequencing. According to MS, the patients were divided into MS group (304 cases) and normal control group (606). Results there was no significant difference in the frequency distribution of AR gene CAG repeat length polymorphism between normal control group and MS group. The systolic blood pressure of 22 group was significantly higher than that of CAG 鈮，

本文編號：1607463