本文選題：非布司他　切入點(diǎn)：痛風(fēng)性關(guān)節(jié)炎　出處：《吉林大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年01期 　論文類型：期刊論文

【摘要】：目的:觀察非布司他治療痛風(fēng)性關(guān)節(jié)炎的療效及治療前后患者受累關(guān)節(jié)彩色超聲圖像的變化。方法:選擇66例男性痛風(fēng)性關(guān)節(jié)炎患者,根據(jù)藥物使用情況分為非布司他組(非布司他40 mg·d-1,n=37)和別嘌醇組(別嘌醇100mg·d-1,n=29),觀察2組患者治療前后血尿酸(UA)、血脂水平和滑膜周圍血流信號(hào)及受累關(guān)節(jié)的彩色多普勒超聲圖像的變化。結(jié)果:2組患者治療后血UA水平下降,與治療前比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05);在16、20和24周,非布司他組患者達(dá)到目標(biāo)血UA值的百分率均較別嘌醇組高,2組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與治療前比較,治療后非布司他組患者高密度脂蛋白(HDL)水平明顯升高(P=0.001),而總膽固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL)水平無(wú)明顯變化(P0.05);別嘌醇組患者治療前后TC、HDL、LDL和TG水平均無(wú)明顯變化(P0.05)。2組患者治療后大部分痛風(fēng)結(jié)晶消失(非布司他組占71.4%,別嘌醇組占58.9%),非布司他組較別嘌醇組痛風(fēng)結(jié)晶溶解效果更佳。2組患者痛風(fēng)急性發(fā)作期的關(guān)節(jié)腔積液、關(guān)節(jié)周圍軟組織腫脹和滑膜周圍血流信號(hào)均有改善,但2組之間比較未見明顯差別。2組患者痛風(fēng)慢性發(fā)作期表現(xiàn)比較無(wú)明顯差異。結(jié)論:非布司他可更有效地降低痛風(fēng)性關(guān)節(jié)炎患者血UA水平,改善痛風(fēng)急性發(fā)作期表現(xiàn),痛風(fēng)結(jié)晶溶解效果更佳。
[Abstract]:Objective: to observe the therapeutic effect of Festa on gouty arthritis and the changes of color ultrasound images of involved joints before and after treatment. Methods: 66 male patients with gouty arthritis were selected. According to the drug use, the patients were divided into two groups: non-buflast group (40 mg 路d ~ (-1)) and allopurinol group (100 mg 路d ~ (-1)) allopurinol. Before and after treatment, the levels of serum uric acid and UAA, blood lipid level, peripheral blood flow signal and color Doppler flow of the involved joints were observed in both groups. Results the serum UA level decreased after treatment in two groups of patients. There were significant differences between before and after treatment (P 0.05), and at the 20th and 24th weeks after treatment, the percentage of patients in the non-busulta group who reached the target blood UA value was significantly higher than that in the allopurinol group (P 0.05), and was significantly higher than that in the allopurinol group (P 0.05), and was significantly higher than that in the control group (P < 0.05). After treatment, high density lipoprotein (HDL) levels were significantly increased in patients with Festalta group, but the levels of TC, TG, TGG and LDL were not significantly changed (P 0.05), while in allopurinol group there were no significant changes in LDL and TG levels of TCU before and after treatment, and there was no significant change in the levels of TCU HDLLDL and TG in allopurinol group before and after treatment. Most of the gout crystals disappeared after treatment (71.4% in the non-Budesta group, 58.9% in the allopurinol group, better dissolution of gout crystals in the non-Budesta group than in the allopurinol group. The swelling of the soft tissue around the joint and the blood flow signal around the synovium were improved. However, there was no significant difference between the two groups. Conclusion: the blood UA level of patients with gouty arthritis can be reduced more effectively, and the symptoms of gout acute attack can be improved. The effect of gout crystal dissolution is better.
【作者單位】： 吉林大學(xué)第一醫(yī)院風(fēng)濕免疫科;
【基金】：吉林省科技廳科技發(fā)展計(jì)劃項(xiàng)目資助課題(20150101152JC)
【分類號(hào)】：R589.7

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