本文選題：骨鈣素　切入點：骨轉換標記物　出處：《中國骨質疏松雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的比較原發(fā)性骨質疏松癥(osteoporosis,OP)患者與對照人群血清骨鈣素(serum osteocalcin,s OC)水平。方法薈萃分析。檢索CENTRAL、Pub Med和CNKI等國內(nèi)外大型數(shù)據(jù)庫,篩選關于骨質疏松癥患者與對照人群s OC水平比較的病例對照研究,對納入研究進行Meta分析,比較在不同性別及檢測不同s OC分子片段的情況下原發(fā)性骨質疏松癥患者與對照人群體內(nèi)的s OC水平,以獲得相關臨床證據(jù)。結果共納入22項女性研究(包括2906人)以及13項男性研究(包括1338人)。絕經(jīng)后骨質疏松(postmenopausal osteoporosis,PMO)組與對照組相比s OC水平明顯升高[95%置信區(qū)間(confidence interval,CI)為(1.59,5.84),P=0.0006],與PMO的高骨轉換率相符。而男性原發(fā)性OP發(fā)病機制不同于PMO,OP組與對照組相比s OC水平無統(tǒng)計學差異[95%CI(-2.31,3.98),P=0.60],此結果可能與男性原發(fā)性OP骨代謝狀態(tài)較為復雜且存在異質性有關。結論 PMO患者s OC水平升高,結果對于PMO具有較高的輔助診斷價值。男性原發(fā)性OP患者s OC水平變化情況仍有爭議,綜合分析結果與對照組無差異。s OC檢測尚缺乏統(tǒng)一標準,本研究結論尚需高質量臨床研究進一步驗證。
[Abstract]:Objective to compare the serum osteocalcinins (OC) levels in patients with idiopathic osteoporosis (OPO) and control group. Methods Meta-analysis was used to search the large databases of CENTRALLPU Pub Med and CNKI at home and abroad. A case-control study on the comparison of OC levels between patients with osteoporosis and a control group was selected, and Meta analysis was performed on the inclusion study. To compare the level of OC between patients with primary osteoporosis and control group with different sex and different fragments of OC molecule. Results in 22 female studies (including 2, 906) and 13 male studies (including 1, 338) and postmenopausal osteoporosis, the levels of OC were significantly higher [95% confidence interval] than in the control group. Confidence intervalency is 1.59 / 5.84 / P 0.0006, which is consistent with the high bone turnover rate of PMO. The pathogenesis of primary op in men is different from that in the control group. There is no significant difference in the level of OC between the two groups [95CI-2.31 ~ 3.98 P0. 60]. This result may be more complicated and more complicated than that of male primary op bone metabolism. Conclusion the level of OC in patients with PMO is higher than that in controls. Results the changes of OC level in male patients with primary op were still controversial, and there was no difference between the results of comprehensive analysis and that of the control group. The conclusion of this study needs to be further verified by high-quality clinical studies.
【作者單位】： 中山大學附屬第三醫(yī)院脊柱外科;中山大學孫逸仙紀念醫(yī)院院長辦公室;
【分類號】：R580

【相似文獻】

相關期刊論文 前10條

1 童書云,蔣綠芝,徐世昌;糖尿病血清骨鈣素水平與臨床[J];遼寧實用糖尿病雜志;2000年03期

2 王大申;尹濰;王維力;張鵬;尹伯元;張梅;;正常成年人血清骨鈣素含量與年齡的相關關系及其意義探討[J];天津醫(yī)藥;1991年02期

3 張R，

本文編號：1591246