本文選題：多囊卵巢綜合征　切入點(diǎn)：抑制素B　出處：《中國實(shí)用婦科與產(chǎn)科雜志》2017年11期 　論文類型：期刊論文

【摘要】：目的分層對(duì)照分析多囊卵巢綜合征(PCOS)患者的臨床基本特征,探討抑制素B(INH B)對(duì)PCOS的臨床意義及與不同臨床表型的相關(guān)性。方法選取2013年6月至2015年12月廣東省計(jì)劃生育�？漆t(yī)院按照Rotterdam標(biāo)準(zhǔn)診斷的148例PCOS患者為病例組,選取月經(jīng)規(guī)律且有正常生育史的女性40例為對(duì)照組。收集調(diào)查對(duì)象基本信息,根據(jù)血清睪酮(T)≥1.97 nmol/L分為高雄激素血癥(HA)組和非高雄激素血癥(NHA)組;根據(jù)穩(wěn)態(tài)模式胰島素抵抗指數(shù)(HOMA-IR)≥2.69分為胰島素抵抗(IR)組和非胰島素抵抗(NIR)組;根據(jù)BMI≥24分為超重組和非超重組;將3組進(jìn)行對(duì)照分析,探討INH B與PCOS不同臨床表型的相關(guān)性。結(jié)果對(duì)照組和PCOS組在BMI、黃體生成素(LH)、LH/卵泡刺激素(FSH)、T、抗苗勒管激素(AMH)和HOMA-IR差異有統(tǒng)計(jì)學(xué)意義[23.13±3.72 vs.30.15±4.42,(7.83±4.53)U/L vs.(4.65±2.00)U/L,1.73±1.82 vs.0.94±0.41,(2.40±1.42)nmol/L vs.(1.45±0.85)nmol/L,(9.21±4.77)μg/L vs.(5.44±3.01)μg/L,3.96±2.45 vs.1.70±0.50,P0.01];INH B差異無統(tǒng)計(jì)學(xué)意義(P0.05)。在HA組和NHA組的比較中,INH B差異有統(tǒng)計(jì)學(xué)意義[(53±28)ng/L vs.(112±37)ng/L,P=0.000],AMH、BMI和HOMA-IR比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);在IR組和NIR組的比較中,BMI和INH B在兩組中的差異有統(tǒng)計(jì)學(xué)意義[21.85±3.41 vs.23.89±3.71,(89±32)ng/L vs.(32±27)ng/L,P0.05],T和AMH差異無統(tǒng)計(jì)學(xué)意義(P0.05);在超重組和非超重組的比較中,HOMAIR和INH B在兩組中的差異有統(tǒng)計(jì)學(xué)意義[(3.35±1.99 vs.5.02±2.76,(86±24)ng/L vs.(38±22)ng/L,P=0.001),T和AMH差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 PCOS具有高度的臨床異質(zhì)性,高雄激素、胰島素抵抗和超重等不同臨床表型可能具有不同的病理生理機(jī)制,導(dǎo)致INH B在不同表型反映不同。
[Abstract]:Objective to analyze the clinical characteristics of polycystic ovary syndrome (PCOS) patients by stratified control. To explore the clinical significance of inhibin PCOS and its correlation with different clinical phenotypes. Methods 148 patients with PCOS diagnosed according to Rotterdam criteria from June 2013 to December 2015 in Guangdong Family Planning Hospital were selected as the case group. Forty women with regular menstruation and normal birth history were selected as control group. The subjects were divided into hyperandrogenemia group and non-hyperandrogenemia group according to the basic information of the subjects, according to the serum testosterone (T) 鈮，

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