本文關(guān)鍵詞： 2型糖尿病 促甲狀腺激素 同型半胱氨酸　出處：《寧夏醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的探討2型糖尿病(T2DM)患者血清中促甲狀腺激素(TSH)與同型半胱氨酸(HCY)的關(guān)系。方法收集2012年12月--2014年4月寧夏醫(yī)科大學(xué)第二附屬醫(yī)院內(nèi)分泌科住院的T2DM患者200例為糖尿病組,年齡(55±15)歲,病程(5.4±3.7)年,其中男性患者88例,女性患者112例。將200例未合并甲狀腺疾病的2型糖尿病患者按促甲狀腺激素(TSH)水平分組:TSH0.3(UIu/m L)組33例,0.3≤TSH≤5.5組132例,TSH5.5組35例;收集寧夏醫(yī)科大學(xué)第二附屬醫(yī)院體檢中心的50例健康體檢者為對照組,年齡(50.61±9.47)歲。檢測促甲狀腺激素與血同型半胱氨酸等指標,并進行相關(guān)分析。結(jié)果1.T2DM患者HCY水平高于正常人(P0.05)。2.T2DM患者三組TSH間HCY差異有統(tǒng)計學(xué)意義,TSH水平與HCY水平呈正相關(guān)(P0.05)。3.HCY水平同T2DM及其慢性并發(fā)癥呈正相關(guān)(P0.05)。4.T2DM患者HCY與Hb A1c(糖化血紅蛋白)、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白(LDL-C)呈正相關(guān)(P0.05),與高密度脂蛋白(HDL-C)呈負相關(guān)(P0.05)。結(jié)論1.2型糖尿病病患者血清中TSH變化與HCY、血管并發(fā)癥呈正相關(guān),提示未合并甲狀腺疾病的2型糖尿病患者,在甲狀腺激素水平正常情況下隨著TSH水平的升高發(fā)生血管并發(fā)癥的風(fēng)險增加,TSH可能是2型糖尿病患者發(fā)生血管病變的危險因素之一。2.2型糖尿病病患者血清中TSH變化與糖、脂代謝相關(guān),提示TSH變化與血糖、血脂、HCY互為因果,監(jiān)測TSH、HCY有助于了解2型糖尿病患者的病情及預(yù)后。
[Abstract]:Objective to investigate the relationship between serum thyrotropin (TSH) and homocysteine (HCY) in patients with type 2 diabetes mellitus (T2DM). Methods from December 2012 to April 2014, 200 patients with T2DM in the Department of Endocrinology, second affiliated Hospital of Ningxia Medical University, were collected as diabetic group. The age was 55 鹵15 years, the course of disease was 5.4 鹵3.7 years, including 88 male patients and 112 female patients. According to the thyroid stimulating hormone (TSH) level, 200 patients with type 2 diabetes mellitus without thyroid disease were divided into 33 cases of TSH 0.3 鈮，

本文編號：1549200