本文關(guān)鍵詞： 碘酸鉀 原花青素 氧化損傷 抗氧化 甲狀腺　出處：《中國(guó)老年學(xué)雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的探討原花青素對(duì)碘酸鉀導(dǎo)致小鼠甲狀腺氧化損傷的保護(hù)作用。方法小鼠按體重隨機(jī)分為5組,空白對(duì)照(NI)組、高碘對(duì)照(HI)組、原花青素低劑量(PL)組、原花青素中劑量(PM)組、原花青素高劑量(PH)組。PL、PM、PH組分別給予不同劑量原花青素。6 w后同時(shí)摘眼球取血,測(cè)血清超氧化物歧化酶(SOD)和谷胱甘肽過氧化物酶(GSH-Px)活性及丙二醛(MDA)含量,并取甲狀腺組織做普通病理切片。結(jié)果 HI組與NI組比較,呈現(xiàn)明顯的抗氧化損傷及甲狀腺病理學(xué)改變。與HI組比較,PL、PM和PH組中GSH-Px活性代償性增高的程度稍有下降;SOD活性及SOD/MDA比值均顯著增加(P0.05);PM組和PH組中MDA含量顯著降低(P0.05)。PM及PH組小鼠的甲狀腺切片無(wú)顯著病理學(xué)改變。結(jié)論原花青素可顯著提高機(jī)體的抗氧化能力并保護(hù)甲狀腺細(xì)胞的正常形態(tài),從而使小鼠甲狀腺免受高碘導(dǎo)致的氧化損傷。
[Abstract]:Objective to investigate the protective effect of procyanidins on thyroid oxidative damage induced by potassium iodate in mice. Methods mice were randomly divided into 5 groups according to their body weight: blank control group, high iodine control group, low dose proanthocyanidin group, middle dose procyanidin group and PMM group. The proanthocyanidins high dose PH. PLP PMN PH group were given different doses of proanthocyanidins at the same time after 6 weeks of extraction of eyeball blood, serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) content were measured. Results the HI group was compared with NI group. In comparison with HI group, the degree of compensatory increase of GSH-Px activity was slightly decreased. Sod activity and SOD/MDA ratio were significantly increased in P0.05 group and PH group, and the content of MDA in P0.05 group and PH group was significantly decreased. There were no significant pathological changes in thyroid sections in P0.05, PM and PH groups. Conclusion Proanthocyanidins can significantly improve the antioxidant capacity of the body and protect the normal morphology of thyroid cells. Thus, the thyroid gland of mice is protected from oxidative damage caused by iodine excess.
【作者單位】： 山東大學(xué)公共衛(wèi)生學(xué)院營(yíng)養(yǎng)與食品衛(wèi)生學(xué)系;山東大學(xué);中國(guó)疾病預(yù)防控制中心;
【基金】：山東大學(xué)大學(xué)生科技創(chuàng)新基金項(xiàng)目(No.2013049);山東大學(xué)自主創(chuàng)新基金(No.2011TB014)
【分類號(hào)】：R581

【相似文獻(xiàn)】

相關(guān)期刊論文 前5條

1 李飛;王國(guó)賢;康雅萍;;原花青素對(duì)Ⅱ型糖尿病大鼠心肌炎癥因子影響[J];中國(guó)公共衛(wèi)生;2012年04期

2 鄒金發(fā);齊鳳杰;董新茜;劉曉光;;原花青素對(duì)高脂血癥模型大鼠脂肪因子及免疫調(diào)節(jié)的影響[J];中國(guó)老年學(xué)雜志;2013年09期

3 涂獻(xiàn)玉;張道明;王文英;張燕翔;杜亞明;雷鴻斌;張斌;;低聚原花青素對(duì)1型糖尿病小鼠抗氧化能力的作用[J];長(zhǎng)江大學(xué)學(xué)報(bào)(自科版)醫(yī)學(xué)卷;2007年04期

4 馮穎;;GSPE預(yù)防肥胖及其代謝異常的實(shí)驗(yàn)研究[J];生物物理學(xué)報(bào);2009年S1期

5 ;[J];;年期

相關(guān)會(huì)議論文 前2條

1 馮穎;郭俊生;;原花青素預(yù)防膳食誘導(dǎo)肥胖的實(shí)驗(yàn)研究[A];中國(guó)營(yíng)養(yǎng)學(xué)會(huì)第十次全國(guó)營(yíng)養(yǎng)學(xué)術(shù)會(huì)議暨第七屆會(huì)員代表大會(huì)論文摘要匯編[C];2008年

2 馮穎;;GSPE預(yù)防肥胖及其代謝異常的實(shí)驗(yàn)研究[A];第十一次中國(guó)生物物理學(xué)術(shù)大會(huì)暨第九屆全國(guó)會(huì)員代表大會(huì)摘要集[C];2009年

，

本文編號(hào)：1521580