本文關(guān)鍵詞： BMD 血脂四項(xiàng) OP 年齡 BMI　出處：《山西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本課題對(duì)來(lái)我院體檢的健康男性人群進(jìn)行腰椎(L1-L4)骨密度(BMD)、血脂四項(xiàng)包括血清總膽固醇(Total Cholesterol,TC)、甘油三酯(Triglyceride,TG)、低密度脂蛋白膽固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白膽固醇(High Density Lipoprotein Cholesterol,HDL-C)的測(cè)定,并探討B(tài)MD與年齡(Age)、體重指數(shù)(Body mass index,BMI)和血脂四項(xiàng)的相關(guān)性。方法:1.一般資料的收集:通過(guò)問(wèn)卷調(diào)查填寫(xiě)研究對(duì)象的Age、既往史、現(xiàn)病史、服用藥物情況,并測(cè)量身高,體重,計(jì)算出BMI,根據(jù)本課題需求篩選出符合要求的251例健康男性體檢者。2.BMD檢測(cè):用美國(guó)Hologic公司生產(chǎn)的型號(hào)為Discovery-Wi型數(shù)字化雙能X線骨密度儀(DXA)來(lái)對(duì)BMD進(jìn)行檢測(cè),每日開(kāi)機(jī)后,先用脊骨模型執(zhí)行一遍系統(tǒng)測(cè)試,系統(tǒng)將運(yùn)行自動(dòng)質(zhì)量控制(Auto QC)測(cè)試。質(zhì)控通過(guò)后方能進(jìn)行人體BMD的檢測(cè),測(cè)定部位與方法:將被檢者性別、出生年月日、身高、體重輸入計(jì)算機(jī),要求被檢者去除身上鑰匙,拉鏈等金屬物品,以免對(duì)結(jié)果有影響,被檢者平躺于測(cè)量床上,用DXA測(cè)量其正位腰椎(L1-4)的BMD,為避免操作誤差,BMD檢測(cè)均由同一個(gè)專業(yè)技術(shù)人員來(lái)完成,由微機(jī)控制儀器,分析后結(jié)果自動(dòng)生成。3.血脂四項(xiàng)檢測(cè):被檢者禁食禁水8 h以上,于次日清晨8點(diǎn)至10點(diǎn)之間采集靜脈血5 m L,離心后并分離出血清,于4 h之內(nèi)完成血脂四項(xiàng)的檢測(cè),采用由深圳邁瑞公司生產(chǎn)的全自動(dòng)生化分析儀器檢測(cè),試劑由山西德盟貿(mào)易有限公司供應(yīng),每批樣本檢測(cè)前,使用檢測(cè)項(xiàng)目所配套的質(zhì)控品完成該項(xiàng)目的質(zhì)量控制檢測(cè)。結(jié)果:1.骨質(zhì)疏松(osteoporosis,OP)組的平均年齡、TC,LDL-C較非OP組高,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。而OP的BMI卻較非OP組低(23.17±3.40 kg/m2 vs 25.30±3.37 kg/m2),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2.L1-4BMD與BMI(r=0.314 P0.05)正相關(guān),與TC(r=-0.181 P0.05),HDL-C(r=-0.141 P0.05)呈負(fù)相關(guān);控制年齡和BMI這兩個(gè)因素后,對(duì)BMD與TG、TC、HDL-C和LDL-C進(jìn)行偏相關(guān)分析:L1-4BMD與TC(r=-0.197 P0.05)仍呈負(fù)相關(guān),與TG(r=-0.145 P0.05),LDL-C(r=-0.148 P0.05)呈負(fù)相關(guān)。3.對(duì)OP相關(guān)危險(xiǎn)因素進(jìn)行Logistic回歸分析:以年齡、BMI、TC、TG、LDL-C、HDL-C為自變量,以O(shè)P為因變量來(lái)進(jìn)行回歸分析。結(jié)果顯示,在控制其他變量的影響時(shí),男性BMI是OP的影響因素,且BMI(回歸系數(shù)B=-0.612,P0.05)是保護(hù)性因素。結(jié)論:1.男性BMI的適當(dāng)增加可能會(huì)降低OP發(fā)生的危險(xiǎn)性。2.對(duì)長(zhǎng)期高血脂癥的病人積極的進(jìn)行降血脂治療可能會(huì)減少OP發(fā)病的風(fēng)險(xiǎn)。
[Abstract]:Objective: to measure the bone mineral density (BMD) of lumbar vertebrae (L1-L4), total cholesterol total Cholesterolus (TCN), triglyceride triglyceride (TGG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and high density lipoprotein cholesterol (HDL-C) in healthy male subjects in our hospital. To explore the correlation between BMD and age, body mass index (BMI) and blood lipids. Methods 1. Collecting general data: filling out the data of age, past history, medical history, taking drugs, measuring height and weight by questionnaire. Calculate BMI and screen out 251 healthy male examiners according to the demand of this subject. 2.BMD test: use Discovery-Wi type digital dual-energy X-ray absorptiometry made by Hologic Company in the United States to detect BMD. After daily booting up, The system will run automatic quality control auto QC test. Quality control can be used to detect human BMD through the rear. The location and method: gender, date of birth, date of birth, height, etc. The body weight was fed into the computer and the subjects were asked to remove metal items such as keys and zippers so as not to affect the results. The subjects lay flat on the measuring bed. In order to avoid the operating error, the detection of L1-4 (L1-4) of the lumbar vertebrae was carried out by the same professional and technical personnel. The results were automatically generated by the microcomputer controlled instrument. The results of the analysis were automatically generated by .3.The four tests of blood lipids were as follows: the subjects fasted for more than 8 hours and were banned from drinking and water for more than 8 hours. The venous blood was collected from 8: 00 am to 10:00 the next day. After centrifugation, the serum was separated, and the four items of blood lipid were detected within 4 hours. The blood lipid was detected by the automatic biochemical analysis instrument produced by Shenzhen Mayrui Company. The reagents were supplied by Shanxi Daimeng Trading Co., Ltd. Before each batch of samples were tested, the quality control products of the test items were used to complete the quality control tests of the project. Results: 1. The average age of the osteoporosis osteoporosis OPO group was higher than that of the non-op group. The BMI of op was 23.17 鹵3.40 kg/m2 vs 25.30 鹵3.37 kg 路m ~ 2 路m ~ (2). There was a positive correlation between BMI(r=0.314 P0.05 and 2.L1-4BMD, and a negative correlation between TC(r=-0.181 P0.05 and HDL-Cr-0.141 (0.05). The partial correlation analysis between BMD and TGT-TGL-HDL-C and LDL-C was that: L1-4BMD was still negatively correlated with TC(r=-0.197 P0.05, and it was negatively correlated with TG(r=-0.145 P0.05LDL-Cnr-0.148 P0.05. Logistic regression analysis was carried out on the related risk factors of op: the age of BMITTCTGL-LDCh HDL-C was taken as independent variable and op as dependent variable. The results showed that, Male BMI is a factor in op when controlling for the effects of other variables. BMI (regression coefficient BU -0.612 P0.05) is a protective factor. Conclusion: 1. The risk of op may be reduced by increasing male BMI. 2. The risk of op may be reduced by active treatment for long-term hyperlipidemia patients.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R580

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