本文關鍵詞： 2型糖尿病 視黃醇結(jié)合蛋白4 胰島素抵抗指數(shù)　出處：《廣西醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的探討血清視黃醇結(jié)合蛋白4(RBP4)與2型糖尿病糖脂代謝、胰島素抵抗的關系方法1、研究對象:2型糖尿病組:選在我院住院的73例無并發(fā)癥的2型糖尿病(T2DM)患者,男41例,女32例;對照組:來我院同期體檢的31例健康人群,男11例,女20例。2、收集兩組的性別、年齡、身高、體重等一般臨床資料,清晨空腹抽取空腹血糖(FPG)、空腹胰島素(FINS)、糖化血紅蛋白(HbA1c)、甘油三酯(TG)、總膽固醇(TC)、高密度脂蛋白-膽固醇(HDL-C)、低密度脂蛋白-膽固醇(LDL-C)、肝腎功能等。計算胰島素分泌指數(shù)(HOMA-β)=FINS(mmol/L)×20/(FPG(mmol/L)-3.5)、胰島素抵抗指數(shù)(HOMA-IR)=FPG(mmol/L)×FINS(mmol/L)/22.5、體重指數(shù)(BMI)=體重(Kg)/身高(m)2;3、比較兩組資料FPG、FINS、HOMA-β、HOMA-IR、HbA1c、TG、TC、HDL-C、LDL-C、RBP4的差異;4、利用spearman相關分析,比較RBP4與FPG、FINS、HOMA-β、HOMA-IR、HbA1c、TG、TC、HDL-C、LDL-C、BMI的相關性;5、用多元逐步回歸分析探討影響2型糖尿病患者血清RBP4的因素。結(jié)果1、T2DM組的FPG、FINS、HbA1c、TG、TC高于對照組,HDL-C低于對照組,p0.05;2、T2DM組的HOMA-IR高于對照組,p0.05,HOMA-β低于對照組,p0.05;3、兩組的RBP4比較示T2DM組的RBP4高于對照組,p0.05;4、采用spearman相關分析結(jié)果顯示,RBP4與FPG、HbA1c、TG呈正相關,r值分別為0.320,0.284,0.334,P0.05。5、以RBP4為因變量,FPG、HbA1c、TG為自變量,采用多元逐步回歸分析結(jié)果示TG是血清RBP4的影響因素。結(jié)論1、T2DM組的血清RBP4高于對照組;2、血清RBP4可能參與T2DM的糖脂代謝紊亂過程;3、TG可能是RBP4的影響因素。
[Abstract]:Objective to investigate the relationship between serum retinol binding protein 4 (RBP4) and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. Objective to investigate the relationship between serum retinol binding protein 4 (RBP4) and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. Objective to investigate the relationship between serum retinol binding protein 4RBP4 and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. There were 32 women and 31 healthy people (11 males and 20 females) in the control group. The general clinical data of sex, age, height, weight and so on were collected from the two groups, such as sex, age, height, weight and so on. Fasting fasting blood glucose (FPG), fasting insulin (FIN), glycosylated hemoglobin (HbA1cN), triglyceride (TGN), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL) -cholesterol (LDL-C), liver and kidney function were extracted in the morning. The difference of insulin resistance index (HOMA-IRR) 脳 FINSINSmol-L / L 脳 FINSMO-L / L) 脳 HOMA-IRFPGmol-L% 22.5, body mass index (BMI) = body mass index (spearman) = body mass index (spearman) = body mass index (KG) / height (MK) was compared between the two groups, and the difference between the two groups was compared between the two groups, and the difference of HDL-CLDL-CnRBP4 between the two groups was analyzed by spearman correlation analysis. To compare the correlation between RBP4 and HOMA- 尾 HbA1 HbA1cTGG (HbA1 cTGN) TGG, and to explore the factors influencing the serum RBP4 of type 2 diabetes mellitus patients by multivariate stepwise regression analysis. Results 1 the HOMA-IR of RBP4 in T2DM group was higher than that in control group (P < 0.05), and the HOMA-IR in TGG group was higher than that in control group (P < 0.05), and the level of HOMA-IR in TGG group was higher than that in control group (p 0.05HOMA- 尾 was lower than that in control group p0.05HOMA- 尾 was lower than that in control group p0.05HOMA- 尾 lower than that in control group p0.05HOMA- 尾). The RBP4 of T2DM group was higher than that of control group (P 0.05). The results of spearman correlation analysis showed that there was a positive correlation between RBP4 and HbA1cU TG in T2DM group, and the positive correlation between RBP4 and HbA1cFG in T2DM group was 0.320 / 0.284 / 0.334P0.05.5, respectively. RBP4 as a dependent variable, HbA1ctroglycerin was an independent variable, and the results of spearman correlation analysis showed that there was a positive correlation between RBP4 and HbA1cTr in T2DM group. The results of multiple stepwise regression analysis showed that TG was the influencing factor of serum RBP4. Conclusion 1 the serum RBP4 of T2DM group is higher than that of control group, and serum RBP4 may be involved in the disorder of glucose and lipid metabolism of T2DM. TG may be the influencing factor of RBP4.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R587.1

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