本文關(guān)鍵詞： 替加環(huán)素 藥品不良反應(yīng) 自動監(jiān)測 藥源性肝損傷 藥源性胰腺炎　出處：《中華醫(yī)院感染學雜志》2017年20期 　論文類型：期刊論文

【摘要】：目的探討住院患者應(yīng)用注射用替加環(huán)素相關(guān)的藥源性肝損傷和藥源性胰腺炎的發(fā)生情況。方法采用回顧性研究方法、借助"醫(yī)療機構(gòu)藥品不良事件(ADE)主動監(jiān)測與智能評估警示系統(tǒng)"監(jiān)測醫(yī)院信息系統(tǒng)(HIS)歷史庫中,選擇2012年3月-2017年3月期間使用過注射用替加環(huán)素的所有住院患者499例,并人工逐一甄別系統(tǒng)報警的疑似藥源性肝損傷和藥源性胰腺炎病例。結(jié)果藥源性肝損傷(DILI)和藥源性胰腺炎(DIP)的實際篩查病例分別為487例占97.60%和424例占84.97%。經(jīng)人工評價具關(guān)聯(lián)性的藥源性肝損傷陽性病例為8例占1.60%,未發(fā)現(xiàn)藥源性胰腺炎陽性病例。8例藥源性肝損傷患者平均(69.75±20.49)歲,平均發(fā)生時間為用藥后(5.25±4.06)天,輕度和重度肝損傷各4例;肝細胞損傷型為3例占37.50%,膽汁淤積型為5例占62.50%;采取停藥及對癥治療后治愈3例、好轉(zhuǎn)2例、持續(xù)3例。結(jié)論 499例替加環(huán)素住院患者中藥源性肝損傷較為常見,略高于說明書,藥源性胰腺炎0例,有待后續(xù)擴大監(jiān)測樣本。利用專項軟件實施自動監(jiān)測,能高效快捷的獲取優(yōu)質(zhì)的真實世界用藥風險數(shù)據(jù),協(xié)助臨床及時識別并規(guī)避用藥風險。
[Abstract]:Objective to investigate the incidence of drug-induced liver injury and drug-induced pancreatitis in inpatients with tegacycline for injection. In the history database of "ADE" active Monitoring and Intelligent Evaluation warning system for Monitoring Hospital Information system (HIS), 499 patients who had used tegacycline for injection between March 2012 and March 2017 were selected. Results the actual screening cases of drug-induced liver injury (DILI) and drug-induced pancreatitis (DIP) were 97.60% cases (97.60% cases) and 84.97 cases (44.97 cases) respectively. The positive rate of drug-induced liver injury was 1.60 years (8 / 8). The average age of the patients with drug-induced liver injury was 69.75 鹵20.49 years old. The average time of occurrence was 5.25 鹵4.06 days after treatment, 4 cases were mild and 4 severe liver injury, 3 cases were hepatocyte injury type (37.50 cases), 5 cases were cholestasis type (62.50%), 3 cases were cured and 2 cases were improved after drug withdrawal and symptomatic treatment. Conclusion liver injury caused by traditional Chinese medicine is more common in 499 patients with tegacycline, which is slightly higher than the specification. There are 0 cases of drug-induced pancreatitis. High-efficient and fast access to real world drug risk data, to help clinical timely identification and avoid drug risks.
【作者單位】： 解放軍總醫(yī)院藥品供應(yīng)中心;重慶醫(yī)科大學藥學院;
【基金】：2014年全軍后勤科研重點基金資助項目(BWS14R039)
【分類號】：R595.3

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本文編號：1499953