本文關(guān)鍵詞： 哈薩克族 維吾爾族 同型半胱氨酸 H型高血壓 患病率 影響因素　出處：《石河子大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的通過現(xiàn)況調(diào)查掌握新疆哈薩克族和維吾爾族農(nóng)村居民高同型半胱氨酸血癥(Hyperhomocysteinemia,HHcy)患病水平及流行特征,對比分析兩民族HHcy相關(guān)影響因素,探討HHcy與高血壓、糖尿病之間的關(guān)系,為進(jìn)一步開展同型半胱氨酸(Homocysteine,Hcy)的研究提供基礎(chǔ)數(shù)據(jù),為心腦血管疾病的發(fā)病機(jī)制及預(yù)防控制提供相關(guān)依據(jù)。方法采用整群隨機(jī)抽樣的方法,2009年-2010年分別在新疆哈薩克族聚居區(qū)伊犁新源縣那拉提鎮(zhèn)和維吾爾族聚居區(qū)喀什伽師縣江巴孜鄉(xiāng)按照區(qū)域分層,以村為單位隨機(jī)抽取6和12個(gè)自然村,通過一對一入戶調(diào)查村中25歲及以上常住居民,收集問卷信息和資料,體檢并采集血標(biāo)本。按性別和年齡分層,在哈薩克族3390人和維吾爾族3821人樣本中分別隨機(jī)抽取1003人、1177人,共計(jì)2180人作為研究對象,檢測血清Hcy及生化指標(biāo)。運(yùn)用SPSS20.0統(tǒng)計(jì)軟件,正態(tài)分布的計(jì)量資料用x±s描述,血清Hcy水平呈正偏態(tài)分布,經(jīng)對數(shù)(lg10)轉(zhuǎn)換后近似正態(tài)分布,以幾何均數(shù)(G)和相應(yīng)的95%可信區(qū)間(95%CI)代表血清Hcy平均水平。兩組均值比較采用獨(dú)立樣本t檢驗(yàn),多組均值比較采用單因素方差分析。計(jì)數(shù)資料采用百分率表示,組間率采用χ2及χ2趨勢檢驗(yàn)進(jìn)行比較;單、多因素及與疾病的關(guān)系使用非條件Logistic回歸進(jìn)行分析并計(jì)算比值比及其95%可信區(qū)間。P0.05(雙側(cè)檢驗(yàn))認(rèn)為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果1.哈薩克族與維吾爾族農(nóng)村居民Hcy水平分別為13.3(9.2~19.4)、13.7(8.8~21.4)μmol/L;HHcy患病率分別為80.0%和78.2%,標(biāo)化患病率哈薩克族為81.9%高于維吾爾族的76.6%,差異有統(tǒng)計(jì)學(xué)意義(χ2=6.391,P=0.001)。男性HHcy患病率分別為93.5%和90.8%,35~歲組,HHcy患病率哈薩克族男性高于維吾爾族男性(P0.05),女性HHcy患病率分別為69.6%和64.4%,其中35~、55~歲組哈薩克族HHcy患病率高于維吾爾族(P均0.05)。2.兩民族HHcy患病率男性高于女性,H型高血壓患病率男性亦高于女性(P均0.05)。3.兩民族人群HHcy患病率有隨年齡增長而升高的趨勢(P0.01)。4.哈薩克族人群HHcy的危險(xiǎn)因素為年齡、男性;維吾爾族人群HHcy的危險(xiǎn)因素有年齡、男性和高血壓。5.哈薩克族農(nóng)村居民高血壓和糖尿病總患病率分別為40.1%、10.0%,維吾爾族居民分別為34.7%、4.5%。兩民族兩種慢性病患病率均隨Hcy水平的增加而升高(P均0.001)。結(jié)論1.新疆哈薩克族和維吾爾族農(nóng)村居民Hcy水平、HHcy、H型高血壓患病率均處于全國較高水平。2.哈薩克族和維吾爾族農(nóng)村居民HHcy患病率男性高于女性,兩民族HHcy患病率均有隨年齡增長而升高的趨勢。3.哈薩克族人群HHcy的危險(xiǎn)因素為年齡、男性;維吾爾族人群HHcy的危險(xiǎn)因素有年齡、男性和高血壓。4.哈薩克族和維吾爾族農(nóng)村居民糖尿病、高血壓患病率有隨Hcy水平增加而升高的趨勢;HHcy可能與兩民族的兩種慢性病相關(guān)。
[Abstract]:Objective to investigate the hyperhomocysteinemia in Kazak and Uygur rural residents in Xinjiang. The prevalence level and epidemic characteristics of Hcy were compared and analyzed in order to explore the relationship between HHcy and hypertension and diabetes mellitus. To provide basic data for further research on homocysteine homocysteine homocysteine (Hcy). Methods Cluster random sampling was used to provide relevant basis for the pathogenesis and prevention and control of cardiovascular and cerebrovascular diseases. 2009 to 2010 in Xinjiang Kazak settlement area Yili Xinyuan County Nalati Town and Uygur area Kashgar Jiashi County Jiangbazi according to the regional stratification. 6 and 12 natural villages were randomly selected from each village. The residents aged 25 and above were investigated by one-to-one household survey, questionnaire information and data were collected, and blood samples were collected and stratified according to sex and age. Among the 3390 Kazakh and 3821 Uygur samples, 1,167 were randomly selected from 1003 people, a total of 2180 people were selected as the subjects of the study. The serum Hcy and biochemical indexes were detected. The normal distribution data were described by x 鹵s and the serum Hcy level was positively skewed by using SPSS20.0 statistical software. The normal distribution is approximately transformed by logarithmic lg10). The average level of serum Hcy was represented by the geometric mean (G) and the corresponding 95% CI (95 CI). The mean values of the two groups were compared by independent sample t-test. Single factor analysis of variance was used to compare the mean values of multiple groups. The counting data were expressed as percentages, and the rates among groups were compared by 蠂 ~ 2 and 蠂 ~ 2 trend tests. Single. Multivariate and disease-related analysis using non-conditional Logistic regression analysis and calculation of the ratio ratio and its 95% confidence interval. P0.05 (bilateral test). The difference was statistically significant. Results 1. The Hcy level of Kazak and Uygur rural residents was 13.3n-2 (19.4). 13.7 渭 mol / L, 8.8 渭 mol / L, 21.4 渭 mol / L; The prevalence of HHcy was 80.0% and 78.2, respectively. The standardized prevalence rate of Kazak was higher than that of Uygur (81.9%), and the difference was statistically significant (蠂 ~ 2 / 6.391). The prevalence rate of HHcy in male was 93.5% and 90.8% respectively. The prevalence rate of Hcy in Kazak nationality was higher than that in Uygur male (P 0.05). The prevalence of HHcy in females was 69.6% and 64.4, respectively. The prevalence of HHcy in Kazak was higher than that in Uygur (P = 0.050.2.The prevalence of HHcy in males was higher than that in females). The prevalence rate of H type hypertension in males was also higher than that in females (P < 0.05). The prevalence rate of HHcy in the two ethnic groups increased with age (P 0.01). Age is the risk factor for HHcy in Kazakh population. Male; The risk factors of HHcy in Uygur population were age, male and hypertension. 5. The total prevalence of hypertension and diabetes were 40.1% and 10.0% in Kazakh rural residents, respectively. Uygur residents were 34.7%. 4.5.The prevalence of chronic diseases in both nationalities increased with the increase of Hcy level (P 0.001). Conclusion 1.The Hcy level of Kazak and Uygur rural residents in Xinjiang is significant. The prevalence of H type hypertension was at a higher level in China. 2. The prevalence of HHcy in Kazakh and Uygur rural residents was higher than that in females. The prevalence of HHcy increased with age. 3. The risk factors of HHcy in Kazakh population were age, male; The risk factors of HHcy in Uygur population were age, male and hypertension .4.The prevalence of hypertension increased with the increase of Hcy level in Kazakh and Uygur rural residents. HHcy may be associated with two chronic diseases in both peoples.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R589

【參考文獻(xiàn)】

相關(guān)期刊論文 前7條

1 喬淑冬;劉娜;高曉紅;樊東升;周建文;;缺血性腦卒中患者高同型半胱氨酸血癥的危險(xiǎn)因素的研究[J];北京醫(yī)學(xué);2011年04期

2 潘燕;孫莉;李玲玲;;新疆維吾爾族、漢族腦梗死患者高同型半胱氨酸與維生素B12、葉酸的相關(guān)性研究[J];中國地方病防治雜志;2014年S2期

3 劉新峰;;缺血性腦血管病介入治療的現(xiàn)狀與今后發(fā)展的方向[J];臨床內(nèi)科雜志;2007年06期

4 但剛;龔揚(yáng)彬;徐萬清;胡宗海;熊杰;;急性冠脈綜合征患者血清hs-CRP、Hcy和ET變化的臨床研究[J];西南國防醫(yī)藥;2010年11期

5 高玉慧;張麗莉;;我國高血壓的流行病學(xué)研究進(jìn)展[J];中國現(xiàn)代醫(yī)生;2008年14期

6 李立明,饒克勤,孔靈芝,姚崇華,向紅丁,翟鳳英,馬冠生,楊曉光,中國居民營養(yǎng)與健康狀況調(diào)查技術(shù)執(zhí)行組;中國居民2002年?duì)I養(yǎng)與健康狀況調(diào)查[J];中華流行病學(xué)雜志;2005年07期

7 吳可貴;;高同型半胱氨酸血癥與老年人認(rèn)知功能障礙相關(guān)性研究[J];中華高血壓雜志;2011年10期

，

本文編號(hào)：1488675