天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

支氣管哮喘患者外周血Th17與Th9細(xì)胞的變化及臨床意義

發(fā)布時(shí)間:2018-01-30 02:22

  本文關(guān)鍵詞: Th細(xì)胞 Th細(xì)胞 哮喘 肺功能 出處:《中國免疫學(xué)雜志》2017年04期  論文類型:期刊論文


【摘要】:目的:探討Th17、Th9細(xì)胞水平在支氣管哮喘患者中的表達(dá)及其臨床意義。方法:選取67例哮喘患者為研究對象,30例健康體檢者為對照組,根據(jù)全球哮喘防治倡議(GINA)將哮喘患者分為間歇與輕度持續(xù)組20例,中度持續(xù)組25例和重度持續(xù)組22例。收集患者臨床資料,完成哮喘控制測試(ACT)評分、肺功能和呼出氣一氧化氮(Fe NO)值測定,流式細(xì)胞儀檢測外周血PBMC中CD3~+CD8~-IL-17~+、CD3~+CD8~-IL-9~+細(xì)胞水平。結(jié)果:與健康對照組相比,哮喘患者Th17、Th9細(xì)胞水平均明顯升高(P0.05);中重度哮喘患者Th17及Th9細(xì)胞水平顯著高于間歇與輕度哮喘組(P0.05),而間歇與輕度哮喘組患者與健康對照組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。哮喘患者外周血Th17及Th9細(xì)胞的表達(dá)均與FeNO值正相關(guān)(r值依次為0.501、0.438;P0.05),與ACT評分、肺功能FEV1、FEV1/FVC及PEF負(fù)相關(guān)(r值依次為-0.441、-0.362;-0.307、-0.377;-0.419、-0.411;-0.428、-0.324;P0.05),同時(shí)Th17與Th9細(xì)胞在哮喘患者外周血中的表達(dá)率正相關(guān)(r值為0.443,P0.05)。結(jié)論:Th17、Th9細(xì)胞在哮喘患者中高表達(dá),具有協(xié)同致炎作用,且與癥狀嚴(yán)重程度相關(guān),提示Th17及Th9細(xì)胞對哮喘患者病情評估有潛在的參考價(jià)值。
[Abstract]:Objective: to investigate the expression of Th17 Th9 cells in patients with bronchial asthma and its clinical significance. Methods: 67 asthmatic patients were selected as the study object and 30 healthy persons as the control group. According to the Global Initiative for the Prevention and treatment of Asthma (GINA), asthmatic patients were divided into intermittent and mild persistent group (n = 20), moderate persistent group (n = 25) and severe persistent group (n = 22). The asthma control test was completed with ACT-score, pulmonary function and exhalation nitric oxide (no) value. The levels of CD3 ~ CD8 + -IL-17 ~ + CD3 ~ CD8 + -IL-9 ~ ~ cells in peripheral PBMC were detected by flow cytometry. Results: compared with the healthy control group. Th17 Th 9 cells were significantly increased in asthmatic patients (P 0.05). The levels of Th17 and Th9 cells in moderate and severe asthmatic patients were significantly higher than those in intermittent and mild asthma groups, while those in intermittent and mild asthma groups were significantly higher than those in healthy controls. There was no significant difference (P 0.05). The positive correlation between the expression of Th17 and Th9 cells in peripheral blood and FeNO value was 0.501 and 0.438 respectively. P0.05, and ACT score, FEV1 / FEV1 / FVC and PEF negative correlation r values were -0.441- 0.362; -0.307, -0.377; -0.419 + -0.411; -0.428 + -0.324; The positive correlation between the expression rate of Th17 and Th9 cells in the peripheral blood of asthmatic patients was 0.443P0.050.Conclusion: 1. The high expression of Th9 cells in asthmatic patients has synergistic inflammatory effect and is related to the severity of symptoms. It suggests that Th17 and Th9 cells have potential reference value for the evaluation of asthma patients' condition.
【作者單位】: 重慶醫(yī)科大學(xué)附屬第一醫(yī)院呼吸與危重癥醫(yī)學(xué)科;
【基金】:國家臨床重點(diǎn)?茖m(xiàng)資助(民辦醫(yī)政函[2012]649號)
【分類號】:R562.25
【正文快照】: (1)本文受國家臨床重點(diǎn)?茖m(xiàng)資助(民辦醫(yī)政函[2012]649號)。支氣管哮喘是由多種細(xì)胞(如氣道上皮細(xì)胞、成纖維細(xì)胞、嗜酸性粒細(xì)胞、中性粒細(xì)胞、T淋巴細(xì)胞、肥大細(xì)胞和平滑肌細(xì)胞等)及其細(xì)胞組分參與的一種慢性氣道炎癥性疾病。免疫功能異常是其重要的發(fā)病機(jī)制[1]。輔助性T

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 程明國;沈若武;王守彪;夏玉軍;;Th9細(xì)胞在兔骨髓炎局部組織中的表達(dá)[J];中國當(dāng)代醫(yī)藥;2012年30期

2 謝振華;任雨;姚許平;;Th9細(xì)胞在器官移植排斥反應(yīng)中的作用[J];醫(yī)學(xué)綜述;2014年11期

3 ;[J];;年期

相關(guān)碩士學(xué)位論文 前1條

1 戚長林;骨性關(guān)節(jié)炎患者外周血中Th9細(xì)胞及IL-9的表達(dá)及其臨床意義[D];吉林大學(xué);2016年

,

本文編號:1475026

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/nfm/1475026.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶4b6b5***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
爽到高潮嗷嗷叫之在现观看| 色婷婷人妻av毛片一区二区三区| 欧美av人人妻av人人爽蜜桃| 欧美熟妇喷浆一区二区| 后入美臀少妇一区二区| 欧美精品久久男人的天堂| 91欧美一区二区三区成人| 91精品国产品国语在线不卡| 欧美性高清一区二区三区视频| 亚洲伦理中文字幕在线观看| 老司机精品视频在线免费| 免费在线播放不卡视频| 亚洲精品中文字幕欧美| 女同伦理国产精品久久久| 亚洲一区二区三区三区| 日本高清一区免费不卡| 亚洲欧美日本国产有色| 儿媳妇的诱惑中文字幕| 神马午夜福利免费视频| 国内外激情免费在线视频| 日韩黄色一级片免费收看| 91蜜臀精品一区二区三区| 日韩国产中文在线视频| 国产农村妇女成人精品| 97人妻精品免费一区二区| 国产日韩欧美专区一区| 东北女人的逼操的舒服吗| 日本一本在线免费福利| 欧美激情区一区二区三区| 欧美一区二区三区性视频 | 国产内射一级一片内射高清| 亚洲一区二区三区三区| 午夜资源在线观看免费高清| 国内胖女人做爰视频有没有| 欧美一区二区三区视频区| 丰满少妇被猛烈插入在线观看| 精品亚洲香蕉久久综合网| 婷婷色香五月综合激激情| 99久久精品午夜一区| 殴美女美女大码性淫生活在线播放 | 欧美日韩乱一区二区三区|