The phosphatidylinositol 3 kinase（PI3K）/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma（RCC） is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemo... 

【文章頁數(shù)】：11 頁

【文章目錄】：
INTRODUCTION
THE PI3K/AKT PATHWAY
    PI3K and upstream regulators
    AKT and downstream effectors
GENETIC ALTERATIONS OF THE PI3K/AKT PATHWAY IN CANCER
GENETIC ALTERATIONS OF THE PI3K/AKT PATHWAY IN RCC
    The PI3K/AKT pathway in ccRCC
    The PI3K/AKT pathway in pRCC
    The PI3K/AKT pathway in chRCC
ADDITIONAL MECHANISMS ACTIVATING THE P13K/AKT PATHWAY IN RCC
TARGETING THE PI3K/AKT PATHWAY IN RCC
CONCLUDING REMARKS



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