【摘要】：目的甲狀腺激素功能改變影響男性性功能的具體生理機(jī)制尚不明確。文中旨在探討甲狀腺激素通過影響陰莖神經(jīng)電生理而誘發(fā)早泄的作用。方法回顧性分析2015年10月至2016年12月于南京總醫(yī)院男科門診就診,并診斷為繼發(fā)性早泄患者52例(早泄組),同期來院進(jìn)行體檢的24名健康男性作為對照組。所有被納入者經(jīng)過男科體檢及甲狀腺激素檢驗。此外,繼發(fā)性早泄患者經(jīng)過陰莖交感皮膚反應(yīng)(PSSR)檢查,根據(jù)PSSR潛伏期長短,將早泄組分為PSSR正常組及異常組。結(jié)果早泄組總四碘甲狀腺原氨酸(TT4)水平顯著高于對照組,差異有統(tǒng)計學(xué)意義[(92.68±11.56)nmol/L vs(102.81±18.37)nmol/L,P=0.018)];與PSSR正常組相比,異常組的TT4及游離四碘甲狀腺原氨酸(FT4)水平均顯著增高,分別為[(95.72±12.42)nmol/L vs(113.28±20.89)nmol/L,P0.01]和[(10.81±1.63)nmol/L vs(12.02±0.88)nmol/L,P=0.003]。FT4與PSSR潛伏期呈負(fù)相關(guān)(r=-0.363,P=0.008),與PEDT呈正相關(guān)(r=0.455,P=0.001)。結(jié)論繼發(fā)性早泄患者異常的PSSR可能與甲狀腺激素的水平升高相關(guān);調(diào)節(jié)伴有異常PSSR的繼發(fā)性早泄患者的甲狀腺激素水平有利于改善其早泄癥狀。
[Abstract]:Objective the effect of thyroid hormone on male sexual function is unclear. The purpose of this paper is to investigate the effect of thyroid hormone on premature ejaculation induced by the effect of penile electrophysiology. Methods from October 2015 to December 2016, 52 patients (premature ejaculation group) were diagnosed as secondary premature ejaculation patients, and 24 healthy men who came to Nanjing General Hospital for physical examination as control group were analyzed retrospectively from October 2015 to December 2016. All participants underwent male medical examination and thyroid hormone test. In addition, the patients with secondary premature ejaculation underwent (PSSR) examination of penile sympathetic skin reaction. According to the PSSR latency, the premature ejaculation group was divided into normal PSSR group and abnormal group. Results the level of total tetraiodothyronine (TT4) in premature ejaculation group was significantly higher than that in control group [(92.68 鹵11.56) nmol/L vs (102.81 鹵18.37) nmol/L,P=0.018]. The levels of TT4 and free tetraiodothyronine (FT4) in abnormal group were significantly higher than those in normal PSSR group, and were [(95.72 鹵12.42) nmol/L vs (113.28 鹵20.89) nmol/L,], respectively. P0.01] and [(10.81 鹵1.63) nmol/L vs (12.02 鹵0.88) nmol/L,P=0.003] .There was a negative correlation between FT4 and the latent period of PSSR (r = -0.363) and a positive correlation with PEDT (r = 0.455P ~ (0. 001). Conclusion abnormal PSSR in patients with secondary premature ejaculation may be related to the increase of thyroid hormone level, and regulating thyroid hormone level in patients with secondary premature ejaculation with abnormal PSSR is helpful to improve the symptoms of premature ejaculation.
【作者單位】： 南方醫(yī)科大學(xué)金陵醫(yī)院(南京軍區(qū)南京總醫(yī)院)生殖醫(yī)學(xué)中心;
【基金】：國家重大基礎(chǔ)研究發(fā)展計劃(2013CB945200)
【分類號】：R698

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