本文選題：前列腺癌 + 前列腺增生�。� 參考：《山東大學(xué)》2014年碩士論文

【摘要】：目的：以病理結(jié)果為參照,采用Siemens3.0T磁共振儀對前列腺中央腺體疾病患者進(jìn)行前列腺MRI檢查,包括常規(guī)序列掃描、磁共振3D1H波譜(MRS)和擴散加權(quán)成像(DWI)等,分析采集圖像中前列腺中央腺體區(qū)疾病包括前列腺癌(PCa)與良性腺體增生(BPH)結(jié)節(jié)兩者在3D1H波譜的代謝變化特點和表觀擴散系數(shù)--ADC值的差異,探討高場強磁共振功能成像3D1H MR波譜(MRS)和擴散加權(quán)成像(DWI)對前列腺中央腺體癌的檢出價值。 材料與方法：選取55例前列腺中央腺體疾病患者,在3.0T磁共振儀上行前列腺MRI檢查,包括前列腺常規(guī)MRI序列、3D’H波譜和擴散加權(quán)(DWI)掃描,所有病例均經(jīng)手術(shù)或直腸穿刺活檢病理證實,其中15例診斷為前列腺癌(PCa),40例診斷為前列腺增生(BPH)。將所得圖像信息數(shù)據(jù)按前列腺6分區(qū)法進(jìn)行分區(qū)測量,15例PCa的中央腺體67個分區(qū)為癌,參照穿刺活檢或病理取材位置,在磁共振采集圖像的中央腺體內(nèi)相應(yīng)部位人工設(shè)置感興趣區(qū),測量該區(qū)CC/C值和ADC值。綜合所得數(shù)據(jù),分析前列腺中央腺體區(qū)癌(PCa)和良性增生(BPH)結(jié)節(jié)的3D1H波譜改變特點以及PCa和BPH在DWI中ADC值的差異。波譜采用Siemens工作站上自帶Spetroscopy軟件測出,ADC值由手工測量得出,所有結(jié)果均以x±s形式表示；所得(膽堿±肌酸)/枸櫞酸鹽(CC/C)值及表觀擴散系數(shù)(ADC)值采用SPSS11.0軟件包進(jìn)行統(tǒng)計學(xué)分析,比較兩組間CC/C值和ADC值,采用t檢驗進(jìn)行組間比較,P0.05認(rèn)為有統(tǒng)計學(xué)意義。 結(jié)果：PCa組和BPH組的CC/C值分別為2.93±1.77和0.67±0.39,兩組間有統(tǒng)計學(xué)差異(P0.05)。PCa組和BPH組的ADC值分別為(0.71±0.32)×10-3mm2·s-1和(1.21±0.26)×10-3mm2·s-1，,癌區(qū)與非癌區(qū)ADC值結(jié)果對比顯示PCa的ADC值減低明顯,兩組間的ADC值的差異亦有統(tǒng)計學(xué)意義(P0.05)。但在所測感興趣區(qū)中,PCa組和BPH組兩組間的部分ADC值有重疊,具體數(shù)值本文未做研究。 結(jié)論：本研究中采用3.0T高場強磁共振,因增加了MR波譜及DWI掃描等功能成像檢查,患者檢查時間較常規(guī)MRI檢查延長,但多數(shù)情況下,前列腺各主要代謝物變化特點和ADC值在中央腺體癌中有明顯的差異,兩者的聯(lián)合應(yīng)用對檢出前列腺中央腺體癌有重要的價值。
[Abstract]:Objective: to study the MRI of prostate in patients with central prostate gland disease by using Siemens 3.0T magnetic resonance imaging (MRI), including conventional sequence scan, magnetic resonance imaging (Mrs) and diffusion weighted imaging (DWI). The metabolic characteristics and apparent diffusion coefficient (ADC) of prostate cancer (PCA) and benign hyperplasia (BPH) nodules in the central gland region of the prostate were analyzed. To evaluate the value of high field magnetic resonance functional imaging (3D1H) Mr spectroscopy (Mrs) and diffusion weighted imaging (DWI) in detecting central gland carcinoma of the prostate. Materials and methods: a total of 55 patients with central gland disease of prostate were examined with 3. 0T magnetic resonance imaging (MRI), including conventional MRI sequence of prostate 3DX H spectrum and diffusion-weighted (DWI) scan. All the cases were confirmed by operation or rectal biopsy, of which 15 cases were diagnosed as prostate cancer (PCA) and 40 cases were diagnosed as benign prostatic hyperplasia (BPH). The image information data were measured according to the prostate 6 division method. The 67 central glands of 15 patients with PCA were classified as cancer. The location of biopsy or pathological examination was used as reference. The region of interest was manually set up in the central gland of magnetic resonance imaging, and the values of CCR / C and ADC were measured. To analyze the characteristics of 3D1H spectra of prostate central glandular carcinoma (PCA) and benign hyperplasia (BPH) nodules and the difference of ADC values between PCA and BPH on DWI. The ADC values measured by Siemens workstation were obtained by hand, all the results were expressed in the form of x 鹵s, and the values of (choline 鹵creatine) / citrate (CC-C) and apparent diffusion coefficient (ADC) were analyzed by SPSS 11.0 software package. Compared the CCR C value and ADC value between the two groups, the t test was used to compare the two groups (P0.05) that there was statistical significance. Results the CC-C values of the two groups were 2.93 鹵1.77 and 0.67 鹵0.39, respectively. There were significant differences between the two groups (P0.05). The ADC values of the PCA group and the BPH group were (0.71 鹵0.32) 脳 10-3mm2 s-1 and (1.21 鹵0.26) 脳 10-3mm2 s-1, respectively. The difference of ADC value between the two groups was also statistically significant (P0.05). However, some ADC values of PCA group and BPH group are overlapped in the measured region of interest. The specific values are not studied in this paper. Conclusion: in this study, 3.0T high-field magnetic resonance imaging was used. The examination time of patients was longer than that of conventional MRI because of the increase of Mr spectrum and DWI scan, but in most cases, the time of examination was longer than that of conventional MRI. The changes of major metabolites and ADC values of prostate were significantly different in central adenocarcinoma, and the combined use of them was of great value in the detection of central prostate carcinoma.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.25;R445.2

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