發(fā)布時(shí)間：2018-03-16 05:10

  本文選題：膀胱過(guò)度活動(dòng)癥　切入點(diǎn)：磁共振波譜成像　出處：《首都醫(yī)科大學(xué)學(xué)報(bào)》2017年06期 　論文類(lèi)型：期刊論文

【摘要】：目的利用氫質(zhì)子磁共振波譜(proton magnetic resonance spectroscopy,1H-MRS)成像探討膀胱過(guò)度活動(dòng)癥(overactive bladder,OAB)患者特定腦區(qū)的代謝變化。方法選擇臨床確診的膀胱過(guò)度活動(dòng)癥患者23例,健康志愿者23例,記錄所有受試者的抑郁自評(píng)量表(Self-rating Depression Scale,SDS)評(píng)分及患者的膀胱過(guò)度活動(dòng)癥患者自我評(píng)價(jià)量表(Overactive Bladder Symptom Score,OABSS)評(píng)分。所有受試者接受顱腦多體素1H-MRS掃描,并利用專(zhuān)用的后處理軟件計(jì)算雙側(cè)額葉前部、中部、后部及雙側(cè)扣帶回前部、后部的N-乙�；扉T(mén)冬氨酸(N-acetyl aspartate,NAA)/磷酸肌酸(creatine,Cr)、膽堿化合物(choline,Cho)/Cr比值,進(jìn)行組間比較。并且,利用Pearson相關(guān)系數(shù)對(duì)NAA/Cr、Cho/Cr比值與SDS、OABSS評(píng)分進(jìn)行相關(guān)分析。結(jié)果 OAB患者雙側(cè)額葉前部、右側(cè)額葉中部、雙側(cè)前扣帶回、左側(cè)后扣帶回的NAA/Cr值較對(duì)照組降低,其余指標(biāo)差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。OAB組右側(cè)額葉中部NAA/Cr比值與SDS評(píng)分呈負(fù)相關(guān)(r=-0.361,P0.05)。結(jié)論~1H-MRS能夠反映OAB患者的腦部代謝變化,為進(jìn)一步的治療提供理論依據(jù)。
[Abstract]:Objective to investigate the metabolic changes in specific brain regions of patients with overactive bladder hyperactivity by using proton magnetic resonance spectroscopy1H-MRS imaging. Methods 23 patients with bladder hyperactivity and 23 healthy volunteers were selected. The self-rating Depression scale (SDSs) scores of all subjects and the overactive Bladder Symptom ScoreBSS scores of patients with bladder hyperactivity were recorded. All subjects were scanned with craniocerebral multivoxel 1H-MRS. The ratio of N-acetyl aspartate NAAU / creatine creatine (Cr), choline compound (choline) in the anterior part, middle part, posterior part and anterior cingulate gyrus of bilateral frontal lobe, middle part, posterior cingulate gyrus and posterior part of the frontal lobe were calculated by the special post-processing software, and the comparison was made between the two groups, and the results showed that the ratio of N-acetyl aspartate NAAU / creatine creatine cr, choline compound was compared between the two groups. Pearson correlation coefficient was used to analyze the correlation between the ratio of NAA / Cr / Cr and the score of OAB. Results the NAA/Cr values of bilateral frontal lobe, right middle frontal lobe, bilateral anterior cingulate gyrus and left posterior cingulate gyrus were lower in OAB patients than those in control group. There was no significant difference in the other indexes. There was a negative correlation between the ratio of NAA/Cr in the middle frontal lobe of right side and the SDS score. Conclusion 1H-MRS can reflect the changes of brain metabolism in patients with OAB, and provide a theoretical basis for further treatment.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院放射科;首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院泌尿外科;
【基金】：國(guó)家自然科學(xué)基金(81541129)~~
【分類(lèi)號(hào)】：R445.2;R694

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 余云紅;;膀胱過(guò)度活動(dòng)癥的護(hù)理及治療體會(huì)(附16例報(bào)告)[J];中國(guó)療養(yǎng)醫(yī)學(xué);2013年02期

2 張瑩;蔡麗玲;王芳麗;;排尿日記在膀胱過(guò)度活動(dòng)癥患者治療中的應(yīng)用[J];護(hù)理學(xué)雜志;2012年24期

3 舒謙;李宏;李先林;;膀胱過(guò)度活動(dòng)癥治療新進(jìn)展護(hù)理體會(huì)[J];大家健康(學(xué)術(shù)版);2013年23期

4 張愛(ài)萍;曹桂英;柴文玲;;不同方法對(duì)前列腺術(shù)后膀胱過(guò)度活動(dòng)癥中的鎮(zhèn)痛效果比較與護(hù)理[J];護(hù)士進(jìn)修雜志;2008年03期

5 黃曉彬;;膀胱過(guò)度活動(dòng)癥保守治療的護(hù)理[J];中國(guó)醫(yī)藥導(dǎo)報(bào);2010年13期

6 張瑩;曾俊;蔡麗玲;;行為轉(zhuǎn)變理論在膀胱過(guò)度活動(dòng)癥患者延伸護(hù)理中的應(yīng)用[J];護(hù)理學(xué)雜志;2014年02期

7 孫知寒,石晶;膀胱過(guò)度活動(dòng)癥的藥物治療[J];中國(guó)康復(fù)理論與實(shí)踐;2001年02期

8 孫一茜;劉秋香;沈秋;;膀胱過(guò)度活動(dòng)癥患者的心理護(hù)理[J];當(dāng)代護(hù)士(中旬刊);2012年02期

9 曾小娟;;膀胱過(guò)度活動(dòng)癥保守治療的心理行為護(hù)理干預(yù)[J];中國(guó)當(dāng)代醫(yī)藥;2013年01期

10 劉麗;姚鮮;;綜合護(hù)理干預(yù)對(duì)膀胱過(guò)度活動(dòng)癥患者的影響[J];中國(guó)臨床護(hù)理;2014年03期

相關(guān)碩士學(xué)位論文 前4條

1 王小娟;2型糖尿病患者膀胱過(guò)度活動(dòng)癥的現(xiàn)狀、危險(xiǎn)因素及其對(duì)生活質(zhì)量的影響[D];山東大學(xué);2015年

2 李靜靜;膀胱過(guò)度活動(dòng)癥患者認(rèn)知行為干預(yù)效果的隨機(jī)對(duì)照試驗(yàn)[D];山東大學(xué);2015年

3 王曦X;認(rèn)知行為干預(yù)對(duì)中老年膀胱過(guò)度活動(dòng)癥患者生活質(zhì)量的影響[D];鄭州大學(xué);2016年

4 李暉;手術(shù)室護(hù)士膀胱過(guò)度活動(dòng)癥現(xiàn)狀及影響因素[D];山東大學(xué);2017年

，

本文編號(hào)：1618455