本文關鍵詞：尿路真菌感染調(diào)查與藥敏分析　出處：《中華醫(yī)院感染學雜志》2016年05期 　論文類型：期刊論文

  更多相關文章： 醫(yī)院感染 尿路感染 真菌 藥敏試驗

【摘要】：目的探討尿路醫(yī)院感染真菌的分布與對抗真菌藥物的敏感性,為臨床合理選擇抗真菌藥物治療提供指導。方法收集2013年7月-2015年7月醫(yī)院收治的經(jīng)中段尿細菌培養(yǎng)確診為尿路真菌感染的237例患者為研究對象,采集患者尿液標本,檢出的菌株采用科瑪嘉顯色培養(yǎng)基進行鑒定,并通過ATBFUNGUS3真菌藥敏試劑進行藥物敏感性試驗。結果清潔中段尿標本,經(jīng)真菌培養(yǎng)后分離得到237株真菌,白色假絲酵母菌113株占47.68%,光滑假絲酵母菌79株占33.33%;患者主要集中在綜合ICU、泌尿外科、心內(nèi)科、內(nèi)分泌科及呼吸內(nèi)科,以上科室尿路真菌感染占83.12%;白色假絲酵母菌、光滑假絲酵母菌及熱帶假絲酵母菌對兩性霉素B和氟胞嘧啶敏感,耐藥率分別為0和0.88%、1.27%和0、0和0,白色假絲酵母菌對氟康唑、伊曲康唑以及伏立康唑的耐藥率均10.00%,而后兩者均10.00%,克柔假絲酵母菌主要對氟胞嘧啶敏感,對伊曲康唑耐藥率38.4%,對伏立康唑的耐藥率30.7%。結論白色假絲酵母菌、光滑假絲酵母菌以及熱帶假絲酵母菌是院內(nèi)尿路真菌感染的主要真菌,其對氟胞嘧啶以及兩性霉素B具有較好的敏感性。
[Abstract]:Objective to investigate the distribution of urinary tract nosocomial infection fungi and the sensitivity of antifungal drugs. Methods from July 2013 to July 2015, 237 cases of urethral fungal infection diagnosed by bacterial culture in middle urinary tract were collected. Object. The urine samples of the patients were collected, and the strains were identified by the Komagar chromogenic medium, and the drug sensitivity tests were carried out by the ATBFUNGUS3 fungal drug sensitive reagent. Results the urine samples were cleaned. 237 strains of fungi were isolated after culture, 113 strains of Candida albicans accounted for 47.68%, 79 strains of Candida smooth accounted for 33.33%. The patients were mainly concentrated in integrated ICU, urology, cardiology, endocrine department and respiratory department. The urinary tract fungal infection accounted for 83.12% in the above departments. Candida albicans, Candida smooth and Candida tropicalis were sensitive to amphotericin B and fluorocytosine, with resistance rates of 0 and 0.88% and 0 and 0, respectively. The resistance rates of Candida albicans to fluconazole itraconazole and voleconazole were 10.00 and 10.00 respectively. The resistance rate to itraconazole was 38.4%, and the resistance rate to voriconazole was 30.7%. Conclusion Candida albicans, Candida smooth and Candida tropicalis are the main fungi of urinary tract fungal infection in hospital. It is sensitive to fluorocytosine and amphotericin B.
【作者單位】： 南陽市中心醫(yī)院泌尿外科;
【基金】：河南省科技發(fā)展基金資助項目(132102310388)
【分類號】：R691.3
【正文快照】： 隨著抗腫瘤藥物、免疫抑制劑以及廣譜抗菌藥物等在臨床上的廣泛應用,導尿管留置時間長等因素,導致真菌性尿路感染的發(fā)病率呈逐漸上升的趨勢[1-2]。本研究回顧性分析2013年7月-2015年7月醫(yī)院收治的尿路真菌感染患者的真菌分布及其對抗真菌藥物的耐藥性,旨在為臨床合理選擇抗真，

本文編號：1427893