本文關(guān)鍵詞：腹膜透析患者固有腹膜高轉(zhuǎn)運的相關(guān)因素分析　出處：《東南大學(xué)學(xué)報(醫(yī)學(xué)版)》2016年01期 　論文類型：期刊論文

  更多相關(guān)文章： 腹膜透析 腹膜高轉(zhuǎn)運 白介素 基因多態(tài)性

【摘要】：目的:探討國人固有型腹膜高轉(zhuǎn)運患者的臨床特點及其相關(guān)因素。方法:回顧性總結(jié)2011年1月至2014年6月因終末期腎臟病行腹膜透析置管的194例患者的臨床資料,將患者按照透析開始后的腹膜轉(zhuǎn)運特性分為低轉(zhuǎn)運組(21例)、低平均轉(zhuǎn)運組(55例)、高平均轉(zhuǎn)運組(93例)和高轉(zhuǎn)運組(25例)4組,比較患者人口學(xué)資料、透析前的生化指標(biāo)以及白介素6(interleukin-6,IL-6)基因單核苷酸多態(tài)性;Logistic回歸分析患者腹膜高轉(zhuǎn)運的獨立危險因素。結(jié)果:4組患者性別分布、心血管并發(fā)癥以及鈣磷乘積水平存在顯著差異(P0.05);4組患者中,IL-6基因T15A多態(tài)性分布有顯著差異(P0.05)�；貧w分析顯示,鈣磷乘積、心血管并發(fā)癥以及IL-6基因T15A多態(tài)性是本組患者腹膜高轉(zhuǎn)運的獨立危險因素。結(jié)論:腹膜透析患者透析前鈣磷乘積水平、心血管并發(fā)癥以及IL-6基因T15A多態(tài)性可能與國人腹膜高轉(zhuǎn)運有關(guān)。
[Abstract]:Objective: To investigate the clinical characteristics of the inherent high peritoneal transport type patients and its related factors. Methods: a retrospective analysis from January 2011 to June 2014 due to end-stage kidney disease clinical data for 194 patients with peritoneal dialysis tube patients, patients according to peritoneal transport characteristics after initiation of dialysis is divided into low transport group (21 cases). Low average transport group (55 cases), high average transport group (93 cases) and high transport group (25 cases) in 4 groups, compared with demographic data, biochemical indexes before dialysis and interleukin 6 (interleukin-6, IL-6) gene polymorphisms; Logistic regression analysis of independent risk factors in patients with high peritoneal transport. Results: 4 groups of patients with gender distribution, there are significant differences in cardiovascular complications and the level of calcium phosphate product (P0.05); the 4 groups of patients, there is significant difference between IL-6 gene T15A polymorphism (P0.05). The regression analysis showed that the calcium phosphorus product, cardiovascular The T15A polymorphism of IL-6 gene is an independent risk factor for the high transport of peritoneum in this group. Conclusion: the level of calcium and phosphorus, the cardiovascular complications and the T15A polymorphism of IL-6 gene in peritoneal dialysis patients may be related to the high transport of peritoneum in Chinese patients.

【作者單位】： 南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院腎內(nèi)科;
【分類號】：R692.5
【正文快照】： (Department of Nephrology,Drum Tower Hospital Affiliated to Medical College ofNanjing University,Nanjing 210008,China)腹膜透析(peritoneal dialysis,PD)是終末期腎臟病替代治療的一種重要方法。近年來的研究表明PD患者的腹膜轉(zhuǎn)運特性與患者的預(yù)后密切相關(guān)。腹膜高轉(zhuǎn)

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